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US Clinical Trial NCT03982121 – NIH – Jun 7, 2019

ISILI (In Situ Immunotherapy of LIver Metastases): An Openlabel, Dose-finding, Phase I Study of Intratumoral Ipilimumab and TLR4 Agonist GLA-SE in Combination With Systemic Nivolumab and Chemotherapy (FOLFOX Regimen) in Patients With Colorectal Liver Metastases.

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US Clinical Trial NCT03982212 – NIH – Jun 7, 2019

A Window of Opportunity Trial of Intratumoral Injection of Copaxone® in Patients With Percutaneously Accessible Tumors

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US Clinical Trial NCT03979274 – NIH – Jun 6, 2019

Prospective, Single Dose, Randomized, Open Label, Comparative, Cross-study to Establish Bioequivalence Between the New Formulation and the Approved Formulation for Levothyroxine (Eutirox® From Merck, S. A. de C. V.) Given as 3 Tablets of 200 μg p.o. in Healthy Volunteers

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US Clinical Trial NCT03980314 – NIH – Jun 6, 2019

A Randomized, Double-Blind, Parallel, Phase 1 Study to Compare the Pharmacokinetics of BMSCHO1-Nivolumab Process D to Nivolumab Process C After Complete Resection of Stage IIIa/b/c/d or Stage IV Melanoma

The study is intended to compare the pharmacokinetic of Process D nivolumab to Process C nivolumab administered after complete resection of Stage IIIa/b/c/d or Stage IV melanoma.
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US Clinical Trial NCT03980535 – NIH – Jun 6, 2019

Evaluation of New Magnetic Resonance (MR) Imaging and Spectroscopy Software

PRIMARY OBJECTIVES: I. To help develop and/or optimize new magnetic resonance (MR) imaging and spectroscopy applications and analysis software in order to provide the best MR services for the investigator's patients. OUTLINE: Patients undergo an...
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US Clinical Trial NCT03980834 – NIH – Jun 6, 2019

Teachers Thriving Together

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US Clinical Trial NCT03981549 – NIH – Jun 6, 2019

Phase I/II Randomized, Prospective, Double-masked, Sham-controlled Study of Intravitreal Autologous Bone Marrow CD34+ Stem Cell Therapy for Central Retinal Vein Occlusion

The goal of this phase I/II prospective, randomized, sham-controlled, double-masked clinical trial is to determine whether intravitreal autologous CD34+ stem cell therapy is safe, feasible and potentially beneficial in eyes with vision loss from cen...
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US Clinical Trial NCT03982160 – NIH – Jun 6, 2019

Role of Decreased Nitric Oxide in the Tonic Elevation of Resting Sympathetic Nerve Activity in Chronic Kidney Disease Patients

The central hypothesis is that accumulation of ADMA constitutes a major mechanism for the sympathetic overactivity and hypertension in patients with CKD. In this study, the investigators will determine if restoration of NO production with the infusi...
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US Clinical Trial NCT03979248 – NIH – Jun 6, 2019

An Open-Label, Single-Sequence Study to Investigate the Effects of Gastric Acid Suppression by Rabeprazole on the Pharmacokinetics of BMS-986165 in Healthy Participants

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US Clinical Trial NCT03979937 – NIH – Jun 6, 2019

Development and Validation of a Simple Diagnostic Tool Predictive of the Aseptic Character of Joint Effusion

In accordance with guidelines and because of the potential gravity that this situation could represent, any joint effusion must be considered as a septic arthritis until proven otherwise, thus justifying an arthrocentesis and an adequate treatment....
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US Clinical Trial NCT03980548 – NIH – Jun 6, 2019

Targeting Mitochondrial Fusion and Fission to Prevent Atherosclerosis: Getting the Balance Right - MITOFFA

Study 1 (tissue sample study): To investigate the changes in mitochondrial function and pro-inflammatory markers in human arterial atherosclerotic plaques. Hypothesis: Macrophages from femoral artery atherosclerotic plaques in patients with periphe...
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US Clinical Trial NCT03981224 – NIH – Jun 6, 2019

Additional Blood Test Enhances Diagnostic Sensitivity of Relapse Detection and Predicts Survivals in High-risk Nasopharyngeal Carcinoma Patients With Post-radiation Detectable Plasma EBV DNA

One week post-radiation therapy (RT) blood test showing persistently detectable EBV DNA is a very poor prognostic factor for nasopharyngeal carcinoma (NPC) patients. We hypothesize that additional EBV DNA confirmation test could enhance diagnostic s...
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US Clinical Trial NCT03981484 – NIH – Jun 6, 2019

REPlaCE- Randomized Trial Evaluating the Use of Prothrombin Complex concEntrate to Improve Survival in Patients With Traumatic Coagulopathy

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US Clinical Trial NCT03981757 – NIH – Jun 6, 2019

Study of Regional Cerebral Oxygenation and Brain Blood Volume Changes During Carotid Endarterectomy Using the NeurOS System

1. Title of the Research Project: Study of Regional cerebral Oxygenation and Brain Blood Volume change during Carotid Endarterectomy using the NeurOS system (COBBV-CE Trial) 2. Background/Problem Statement: The use of regional cerebral oxygenation...
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US Clinical Trial NCT03979066 – NIH – Jun 6, 2019

A Phase 2, Open-Label, Multicenter, Randomized Study Evaluating NEOadjuvant Immunotherapy Based Combinations in Patients With Resectable PANCreatic Ductal Adenocarcinoma

Presently, surgical resection offers the only therapeutic means of cure. However only 15%-20% of patients are found to have resectable disease at time of initial diagnosis. Of the patients who undergo curative surgery, most will relapse and eventual...
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US Clinical Trial NCT03979820 – NIH – Jun 6, 2019

A Phase I Parallel Group Study in Healthy Subjects to Evaluate the Effect of Multiple Oral Doses of BI 1467335 and Phenelzine as Positive Control on Blood Pressure Response to Oral Tyramine (Double-blind, Randomised, Placebo-controlled Design for BI 1467335 Treatment Groups, Open Label for Phenelzine)

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US Clinical Trial NCT03980002 – NIH – Jun 6, 2019

A Prospective Multicenter Phase 2 Study of FCR/BR Alternating With Ibrutinib in Treatment-naive Patients With Chronic Lymphocytic Leukemia

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US Clinical Trial NCT03980067 – NIH – Jun 6, 2019

Pediatric Procedural Sedation and the Relationship With Post-Discharge Negative Behavioral Changes in the Emergency Department

This randomized control trial will investigate the use of a virtual reality (VR) distraction game prior to IV ketamine procedural sedation for long bone fracture reduction. Prior studies have demonstrated that children undergoing anesthesia or proce...
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US Clinical Trial NCT03980223 – NIH – Jun 6, 2019

Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men

The overarching goal is to assess the effectiveness of doxycycline PEP on incidence of STIs and tetracycline resistance among STIs and commensal bacteria to inform public health policy. Participants will be randomized 2:1, with a greater number rece...
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US Clinical Trial NCT03980301 – NIH – Jun 6, 2019

Screening Hepatitis Positive Women for Congenital Anomalies During Pregnancy

Hepatitius positive women should be screened for congenital anomalies
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US Clinical Trial NCT03980496 – NIH – Jun 6, 2019

Effects of Different Omeprazole Dosing on Gastric pH in Non- Variceal Upper Gastrointestinal Bleeding: A Randomized Prospective Study

The patients with non-variceal upper gastrointestinal bleeding (NVUGIB) are prospectively enrolled. After the achievement of endoscopic hemostasis, the patients are randomized to 40-mg intravenous (i.v.) OME bolus injection every 12 h or 8-mg/h cont...
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US Clinical Trial NCT03980808 – NIH – Jun 6, 2019

American Sign Language-Accessible Diabetes Education

Georgia Tech's Center for Advanced Communications Policy (CACP) proposes the American Sign Language Accessible Diabetes Education (ASL-ADE) project in response to the Georgia Center for Diabetes Translation Research for a pilot and feasibility study...
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US Clinical Trial NCT03980860 – NIH – Jun 6, 2019

Effect of HIIT vs Low Intensity Training on Fat Loss in Obese Patients

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US Clinical Trial NCT03981250 – NIH – Jun 6, 2019

The ONE Study: Effect of One Minute of Resistance Exercise Per Day on Muscular Strength

A resistance training programme can lead to a variety of health benefits including increases in muscle size and strength. Other potential health benefits of resistance training include reduction of body fat, increased metabolic rate, improve insulin...
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US Clinical Trial NCT03981393 – NIH – Jun 6, 2019

Propensity Matching Study of Early v.s. Delayed VV ECMO in Severe Respiratory Failure

VV ECMO is increasingly used in refractory respiratory failure. Despite advances in lung protective ventilation strategies, patients who have severe respiratory failure often develop complications from mechanical ventilation, including volutrauma an...
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US Clinical Trial NCT03981406 – NIH – Jun 6, 2019

The Impact of Palliative Care on Quality of Life, Anxiety, and Depression in Patients With Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and heterogeneous fibrotic lung disease. It is universally fatal, with an average time to death between two to five years. Patients with IPF experience significantly diminished quality of life an...
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US Clinical Trial NCT03981835 – NIH – Jun 6, 2019

Management of Antiplatelet Regimen During Surgical Procedures (MARS Registry)

There are key differences today in clinical practice regarding perioperative management of post-PCI patients on DAPT undergoing NCS. Moreover, there are significant differences between bridging agents, and improved safety of current-generation DES....
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US Clinical Trial NCT03981887 – NIH – Jun 6, 2019

A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of Intravenous Nafithromycin in Healthy Subjects

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US Clinical Trial NCT03982069 – NIH – Jun 6, 2019

Immunological Response to Influenza Vaccination in Children, Adolescents, and Young Adults: A RCT of FluMist vs. Flucelvax

This is a non-blinded, randomized controlled trial analyzing influenza vaccine immunogenicity response in children/adolescents/young adults aged 4-21 years given one of two FDA approved and licensed influenza vaccines: FluMist (live attenuated influ...
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US Clinical Trial NCT03982108 – NIH – Jun 6, 2019

Comparison of Repair Integrity and Functional Outcomes Between Knot-tying and Knotless Suture-bridge Arthroscopic Rotator Cuff Repair: a Prospective Randomized Clinical Trial

This study has been planned as a prospective randomized clinical trial. We used a completely computer-generated list in order to randomize all participants to receive one of two treatments (https://www.random.org/sequences/). Rotator cuff tear diag...
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US Clinical Trial NCT03982251 – NIH – Jun 6, 2019

The Effects of Whole Body Vibration Training With Different Frequencies on Bone Health and Neuromotor Performance in Individuals With Chronic Stroke: A Randomized Controlled Trial.

Whole body vibration (WBV) has been found to be useful in promoting bone health and muscle performance in older adults. To date, no study has examined the effects of different WBV frequencies on the properties of the muscle-bone unit in stroke patie...
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US Clinical Trial NCT03978507 – NIH – Jun 6, 2019

Digital Wearable Walking Aid for Freezing of Gait in Parkinson´s Disease

The objective of this study is to investigate the effects of relatively long-term use of a wearable device that provides personalized and intelligent cues (e.g. only when FOG is detected) on FOG. It is hypothesized that the use of this device will r...
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US Clinical Trial NCT03979131 – NIH – Jun 6, 2019

Phase II Study of Avelumab Plus Chemotherapy in the Peri-operative Treatment for Patients With Resectable Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJC)

Phase II Study of Avelumab plus chemotherapy in the peri-operative treatment for patients with resectable Gastric cancer (GC) or Gastroesphageal Junction cancer (GEJC) The addition of Avelumab to the perioperative chemotherapy in GC and GEJC patien...
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US Clinical Trial NCT03979261 – NIH – Jun 6, 2019

Gender Study on Predisposition to Infectious Endocarditis

Numerous epidemiological studies have made it possible to highlight the impact of the genus on the occurrence and natural evolution of numerous valvulopathies. Severe valve leakage occurs more frequently in men. This association is also observed in...
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US Clinical Trial NCT03979638 – NIH – Jun 6, 2019

A Randomized, Double-Blind, Placebo-Controlled, Crossover, Dose Escalation Study of BLU-5937 in Subjects With Unexplained or Refractory Chronic Cough (RELIEF)

This study will have two 16-day treatment periods (four escalating doses or matching placebo at four days interval) separated by a 10 to 14-day washout period. There will be a 14-day follow-up period.
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US Clinical Trial NCT03980327 – NIH – Jun 6, 2019

The Use of Probiotic Dietary Supplementation to Alter the Intestinal Microbiota and Improve Growth in Children With Short Bowel Syndrome

1. Introduction and Purpose: The goal of this project is to improve linear growth and weight gain in children with short bowel syndrome by changing their intestinal microbiota and ultimately intestinal bacterial metabolism. 2. Background: Short bow...
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US Clinical Trial NCT03980379 – NIH – Jun 6, 2019

A Study of Pharmacokinetics, Efficacy, and Safety of 304 Injection Compared With Rituximab in B Cell Non-Hodgkin's Lymphoma

This is a multi-center, randomized, double-blind, parallel controlled, single-dose study to evaluate the pharmacokinetic, safety and efficacy of 304 injection compared with rituximab injection. To avoid the impact of tumor burden on pharmacokinetics...
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US Clinical Trial NCT03980418 – NIH – Jun 6, 2019

Comparative Study of DaTSCAN ™ Cerebral Tomoscintigraphy Recorded by Conventional Anger Cameras and Semiconductor Camera (VERITON-CT ™)

The clinical study is monocentric, interventional, non randomized, with minimal riks and contraints. All patients going to the nuclear medicine department for a DaSCAN exam will be able to participate in this study if they understood the study info...
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US Clinical Trial NCT03980509 – NIH – Jun 6, 2019

A "Window Trial" on Curcumin, the Active Compound in Turmeric, for Invasive Breast Cancer Primary Tumors

The purpose of this study is to determine whether oral administration of Curcuma longa extract causes biological changes related to apoptosis (DNA fragmentation) and cell proliferation (Ki67) in primary tumors of breast cancer patients.
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US Clinical Trial NCT03980561 – NIH – Jun 6, 2019

Varenicline for the Treatment of DSM 5 Cannabis Use Disorder in Adults

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US Clinical Trial NCT03981588 – NIH – Jun 6, 2019

CARDIOTOXICITY IN THE ELDERLY

Surveys completion and examinations will be obtained at the same day: within 72 hours before each cycle of treatment or at 3, 6, 9, 12 months, 3 years and 5 years' follow-up after ending the whole antitumoral course of treatment. A fully dedicated r...
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US Clinical Trial NCT03982420 – NIH – Jun 6, 2019

The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation

This is a prospective, single-arm, multi-center evaluation of patients requiring carotid revascularization who are treated with the FDA-cleared ENROUTE Transcarotid NPS in conjunction with the FDA-approved ENROUTE Transcarotid Stent System. Both the...
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US Clinical Trial NCT03982511 – NIH – Jun 6, 2019

Improving Parent-Child Interactions to Prevent Child Obesity in Early Childhood

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US Clinical Trial NCT03978858 – NIH – Jun 6, 2019

A Phase 2 Study of Cusatuzumab Plus Azacitidine in Patients With Newly Diagnosed Acute Myeloid Leukemia Who Are Not Candidates for Intensive Chemotherapy

AML is a heterogeneous disease characterized by uncontrolled clonal expansion of hematopoietic progenitor cells. As the most common form of acute leukemia, AML accounts for the largest number of annual deaths from leukemia. Over 95 percent (%) of AM...
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US Clinical Trial NCT03979625 – NIH – Jun 6, 2019

Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation

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US Clinical Trial NCT03979807 – NIH – Jun 6, 2019

The Role of Inhaler Device in the Treatment Persistence With Dual Bronchodilators in Patients With COPD

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US Clinical Trial NCT03979989 – NIH – Jun 6, 2019

An Open-Label, Two-Way Crossover, Drug-Interaction Study to Determine the Effect of Omeprazole on the Pharmacokinetics of an Immediate-Release Capsule of CG5503 in Healthy Subjects

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US Clinical Trial NCT03980054 – NIH – Jun 6, 2019

A Phase III Study to Evaluate the Efficacy and Safety of Pyrotinib Versus Placebo in Patients With Human Epidermal Growth Factor Receptor 2 (HER2) Positive Early or Locally Advanced Breast Cancer After Adjuvant Trastuzumab

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US Clinical Trial NCT03980353 – NIH – Jun 6, 2019

Evaluation of Difficulties and Obstacles to the Integration in Community of Children With Type 1 Diabetes Before Primary School, Followed by the Diabetology Department of Lyon Pediatric Hospital.

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US Clinical Trial NCT03980431 – NIH – Jun 6, 2019

Safety and Clinical Value of 18Fluorine-labeled Boron Tyrosine PET/CT in Patients With Brain Tumors

FBY is a new PET tracer derived from tyrosine, with the carboxyl group replaced by boron trifluoride, and is transferred across cell membrane through LAT-1. LAT-1 is a sodium independent amino acid transporter and is highly expressed in tumor cells....
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