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US Clinical Trial NCT03843138 – NIH – Feb 14, 2019

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US Clinical Trial NCT03842852 – NIH – Feb 14, 2019

Comparition of the Results of Inguinal Hernia Repair Using Laparoscopic Total Extra-peritoneal or Open Prolene Hernia System Approach

In our environment, 10367 (10.41% of all surgeries) hernia repair are performed in one year, of witch 5797 (51.92%) are inguinal hernia repair, of them 2870 (49.51%) are performed laparoscopically and 2927 (50.49%) are performed using different open...
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US Clinical Trial NCT03842826 – NIH – Feb 14, 2019

Inter-examiner Reproducibility of Clinical Examination Tests for Athletes With Longstanding Groin Pain

The "Doha agreement meeting on terminology and definitions" aimed to simplify the heterogeneous taxonomy of groin injuries by creating a straightforward classification system based on patient history and clinical examination. Following this classifi...
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US Clinical Trial NCT03843151 – NIH – Feb 14, 2019

Relative Bioavailability of a Single Oral Dose of BI 1358894 When Administered Alone or in Combination With Multiple Oral Doses of Itraconazole in Healthy Male Subjects (an Open-label, Fixed Sequence Study)

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US Clinical Trial NCT03842800 – NIH – Feb 14, 2019

Characterizing Clinical and Pharmacological Neuroimaging Biomarkers

Cognition rarely occurs in the 'real world' in isolation, and typically occurs under emotional influences that may alter how cognition occurs. Understanding these motivational and cognitive interactions will help better assess mechanisms that underl...
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US Clinical Trial NCT03842891 – NIH – Feb 14, 2019

Genetic Variants Modulate Association Between Dietary n-3 LCPUFAs and DHA Proportion in Breast Milk

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US Clinical Trial NCT03843125 – NIH – Feb 14, 2019

A Phase 3, Double-Blind, Multicenter Study to Evaluate the Long-Term Safety and Efficacy of Baricitinib in Patients With Systemic Lupus Erythematosus (SLE)

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US Clinical Trial NCT03843060 – NIH – Feb 14, 2019

A Phase 1 Single Center Open-label, Non-randomized, Fixed Sequence Study in Healthy Volunteers to Assess the Pharmacokinetics (PK) of AZD9977 When Administered Alone and With Itraconazole

This is an open-label, non-randomized, fixed sequence study conducted at a single study center with primary aim to assess the pharmacokinetics (PK) of AZD9977 in healthy volunteers when administered alone and in combination with multiple doses of it...
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US Clinical Trial NCT03841630 – NIH – Feb 13, 2019

A Single-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3437943 in Healthy Subjects

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US Clinical Trial NCT03842150 – NIH – Feb 13, 2019

Development and Validation of a Screening Score for the Biliary Atresia in Infantile Cholestasis: A Prospective Study

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US Clinical Trial NCT03842293 – NIH – Feb 13, 2019

Clinical Evaluation of PROMIS Pediatric Person Reported Outcome Measures in Children With Chronic Kidney Disease

The National Institutes of Health (NIH)-sponsored Patient-Reported Outcomes Measurement Information System (PROMIS) network has developed over 20 pediatric instruments, both child-report and parent-proxy editions. Cross-sectional evaluations of the...
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US Clinical Trial NCT03842865 – NIH – Feb 13, 2019

An Expanded Access Trial of Vigil (Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in Advanced Solid Tumors

Approximately 40 subjects who had tissue procured and Vigil manufactured but fail manufacturing release criteria under a previous Gradalis protocol are considered for this study. Participants will be managed in an outpatient setting. Hematologic fu...
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US Clinical Trial NCT03842215 – NIH – Feb 13, 2019

Development and Clinical Applications of a Smart Physical Examination System for the Health Management in Elderly

Aging usually results in a decline of motor function. However, elderly tends to refuse the regular health examination because of travel issues or lack of self-health awareness. Examination unit also has difficulty to intensively track and instantly...
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US Clinical Trial NCT03842696 – NIH – Feb 13, 2019

A Phase 1/2 Multi-Center Trial of Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Unrelated Donor Blood and Marrow Transplantation

All subjects will undergo unrelated donor allogeneic blood and marrow transplant (BMT) according to local site institutional practice. The preparative regimen will depend upon the subject's underlying disease, previous therapy, and comorbidities. GV...
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US Clinical Trial NCT03843099 – NIH – Feb 13, 2019

Decisions About Exercise During Weight Loss: Pilot Study

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US Clinical Trial NCT03843177 – NIH – Feb 13, 2019

Association of Ingrown Toenails With Flat Foot, Hallux Abducto Valgus and Hallux Limitus

This study will have implications for any healthcare professionals who routinely manage ingrown toenails. Although different conservative and surgical treatment have been suggested, the recurrent rate is still high ranging from 20% to 30%. The objec...
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US Clinical Trial NCT03841175 – NIH – Feb 13, 2019

Forecasts Impact of the Pre-therapeutic TEP-TDM in the 18-FDG Restaging of Upper Aero-digestive Tract Cancers

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US Clinical Trial NCT03841305 – NIH – Feb 13, 2019

SIMULTANEOUS PORTAL AND HEPATIC VEIN EMBOLIZATION Versus PORTAL VEIN EMBOLIZATION FOR HYPERTROPHY OF THE FUTURE LIVER REMNANT BEFORE MAJOR HEPATECTOMY OF NON-CIRRHOTIC LIVER: A MULTICENTRIC COMPARATIVE RANDOMIZED PHASE II TRIAL.

Portal vein embolization (PVE) has been widely used to generate hypertrophy of the nonembolized lobe in patients undergoing major hepatectomy in order to prevent small-for-size remnant liver resulting in post-operative liver insufficiency. Although...
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US Clinical Trial NCT03841617 – NIH – Feb 13, 2019

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

Study rationale High risk patients with differentiated thyroid cancer (DTC) require therapy with 131 I under thyroid stimulating hormone (TSH) stimulation. There are two methods of TSH stimulation endogenous by thyroid hormone withdrawal (THW) lead...
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US Clinical Trial NCT03841721 – NIH – Feb 13, 2019

Pharmacokinetics/Pharmacodynamics of Oral Linezolid 300 mg/Day in Healthy Volunteers

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US Clinical Trial NCT03842059 – NIH – Feb 13, 2019

Computer-aided Detection With Deep Learning for Colorectal Adenoma During Colonoscopic Examination

Colonoscopy is a primary screening and follow-up tool to detect colorectal cancer, a third leading cause of cancer death in Taiwan. Most colorectal cancers (CRCs) arise from preexisting adenomas, and the adenoma-carcinoma sequence offers an opportun...
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US Clinical Trial NCT03842072 – NIH – Feb 13, 2019

The Collar Post Anterior Cervical Spine Surgery (C-PASS) Study: Project Proposal for a Multi-Center Randomized Trial Evaluating the Impact of Post-Operative Bracing on Clinical Outcomes After Anterior Cervical Discectomy and Fusion.

The Anterior Cervical Discectomy and Fusion (ACDF) represents one of the most commonly performed spinal operations internationally, often in the context of symptomatic radiculopathy or myelopathy secondary to cervical degenerative disease. Approxima...
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US Clinical Trial NCT03842098 – NIH – Feb 13, 2019

Korean Medicine Patient Registry of Post-operative Therapy for Musculoskeletal Disorders - Prospective Multicenter Observational Registry -

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US Clinical Trial NCT03842137 – NIH – Feb 13, 2019

tDCS to Decrease Opioid Relapse

This study has two phases. In phase one (UG3), we propose to use FMRI to quantify changes in brain function and reported craving before and after administration of five sessions of tDCS+Cognitive Control Network (CCN) priming stimulation vs. sham tD...
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US Clinical Trial NCT03842163 – NIH – Feb 13, 2019

PREVALENCE AND CHARACTERISTICS OF TRANSTHYRETIN AMYLOIDOSIS IN PATIENTS WITH LEFT VENTRICULAR HYPERTROPHY OF UNKNOWN ETIOLOGY TTRACK

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US Clinical Trial NCT03842176 – NIH – Feb 13, 2019

Clinical Application of CTC in Operable Breast Cancer Patients

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US Clinical Trial NCT03842501 – NIH – Feb 13, 2019

A Randomized, Double-blind, Placebo-controlled Study Evaluating the Effects of the GOLO Weight Management Program With and Without Release Supplement on Weight and Metabolic Parameters in Subjects With Obesity

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US Clinical Trial NCT03842761 – NIH – Feb 13, 2019

Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety, Tolerability, and Pharmacokinetics of Multiple Rising Oral Doses of BI 685509 Over 28 Days in Patients With Mild and Moderate Hepatic Impairment and of Single Oral BI 685509 Dose Compared to Healthy Volunteers

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US Clinical Trial NCT03842995 – NIH – Feb 13, 2019

South-seq: DNA Sequencing for Newborn Nurseries in the South

Barriers to widespread and routine implementation of WGS-enabled clinical care exist at several levels. Surveys of clinicians indicate discomfort in their understanding of genomics and ability to communicate results to patients, and also concern abo...
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US Clinical Trial NCT03841188 – NIH – Feb 13, 2019

Calcium Intake Improvement After Nutritional Intervention in Pediatric Patients With Osteogenesis Imperfecta

Nutrition Intervention NI was performed at three nutritional visits (baseline, 6 and 12 months). Clinical features were evaluated at baseline, including anthropometric measurements, basal metabolic rate (BMR), BMD An indirect calorimetry test was pe...
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US Clinical Trial NCT03841318 – NIH – Feb 13, 2019

Involvement of Immune Cells Derived From the Intestine in Sjogren's Syndrome

Autoimmune diseases are characterized by a loss of tolerance of the immune system for self-antigens. One of the feature of autoimmune diseases is the infiltration of lymphoid cells in the tissues damaged by the disease (i.e. kidney in systemic lupus...
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US Clinical Trial NCT03841565 – NIH – Feb 13, 2019

Randomized Phase II Trial of Daratumumab Retreatment in Patients With Relapsed Multiple Myeloma

PRIMARY OBJECTIVES: I. To determine the overall response rate (partial response [PR], very good partial response [VGPR], complete response [CR], or stringent complete response [sCR]) of daratumumab retreatment in combination with either pomalidomid...
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US Clinical Trial NCT03841591 – NIH – Feb 13, 2019

Maternal Weight Gain in Gestational Diabetes Controlled by Metformin Versus Insulin: A Randomized Controlled Trial

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US Clinical Trial NCT03841643 – NIH – Feb 13, 2019

Comparison of Calcium Phosphate Cement With Patient-specific Implants for Cranial Reconstruction: a Randomized-controlled Trial

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US Clinical Trial NCT03842046 – NIH – Feb 13, 2019

Comparison of Continuous Infusion of Noradrenaline Versus Phenylephrine During Cesarean Section Under Spinal Anesthesia. A Randomized Controlled Trial

- Spinal anesthesia is the anesthetic technique of choice for elective cesarean section. - Spinal anesthesia can be complicated by hypotension, with incidence exceeding 80% occasionally. Hypotension can lead to nausea, emesis and a subjective feeli...
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US Clinical Trial NCT03842202 – NIH – Feb 13, 2019

Effect of Semaglutide 2.4 mg Once-weekly on Gastric Emptying in Subjects With Obesity

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US Clinical Trial NCT03842267 – NIH – Feb 13, 2019

A Multicenter, Randomized, Placebo-controlled, Parallel Group, Double-blind, Phase III Study to Evaluate the Efficacy and Safety of Gemigliptin 50mg in Patients With Type 2 Diabetes Who Have Inadequate glycemIc Control With Dapagliflozin and Metformin

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US Clinical Trial NCT03842436 – NIH – Feb 13, 2019

Feasibility and Acceptability of Digital Pills to Monitor PrEP Adherence in MSM With Substance Use

Eligible study participants will be screened and enrolled at Fenway Health (Boston, MA). Participants will complete a quantitative assessment on their history fo substance use, sexual risk and PrEP adherence, and be trained to use the digital pill f...
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US Clinical Trial NCT03842527 – NIH – Feb 13, 2019

Pre-Operative Gastric Volume Assessment Following Carbohydrate-Loading in Obstetrical Patients Undergoing Elective Cesarean Section: A Randomized Clinical Pilot Study

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US Clinical Trial NCT03842683 – NIH – Feb 13, 2019

Are Todays Continuous Glucose Monitoring Precise and Can They be Used to Reveal and Reduce Glycaemic Variability?

The following study is an exploratory investigation of continuous glucose monitoring based on data from a completed Novo Nordisk A/S clinical trial. Please refer to ClinicalTrials.gov Identifier: NCT02825251. Continuous Glucose Monitoring (CGM) pro...
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US Clinical Trial NCT03843008 – NIH – Feb 13, 2019

Role of Melatonin in the Acute Phase of Stroke as Measured by Interleukin 6 Biomarker

Stroke is a major cause of debilitation in the first world, with few therapeutic options when it comes to improvement in quality of life and morbidity, besides physical and occupational therapy. It affects people of all nationalities, creeds, and so...
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US Clinical Trial NCT03843021 – NIH – Feb 13, 2019

Understanding and Addressing Variation in Healthcare-Associated Infections After Durable Ventricular Assist Device Therapy: Organizational: Aim 1 Survey

Annually, more than 250,000 patients in the U.S. with end-stage heart failure stand to benefit from ventricular assist device (VAD) therapy. Despite VADs providing long-term "durable" support, this therapy is associated with substantial risk (50% mo...
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US Clinical Trial NCT03843164 – NIH – Feb 13, 2019

Lung Nodule Characterization by Artificial Intelligence Techniques

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US Clinical Trial NCT03841448 – NIH – Feb 13, 2019

A Phase 2, Randomized, Double-blind, Placebo-controlled Study of Cemdisiran in Adult Patients With IgA Nephropathy

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US Clinical Trial NCT03841461 – NIH – Feb 13, 2019

Investigation of the Effect of Physical Activity Level on Sleep Quality and Fatigue in Academicians

The aim of this study is to investigate that the effect of physical activity level on sleep quality and fatigue in academicians. First of all, a form including the purpose of the study, demographic information, daily working hours and assignment du...
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US Clinical Trial NCT03842319 – NIH – Feb 13, 2019

Impact of MEditerranean Diet, Inflammation and Microbiome on Plaque Vulnerability and Microvascular Dysfunction After an Acute Coronary Syndrome. A Randomized, Controlled, Mechanistic Clinical Trial.

Coronary atherosclerosis is a leading cause of mortality and disability worldwide. Continuous efforts are needed to improve secondary prevention and understand the mechanism underlying disease progression. Based on primary prevention trials, a poten...
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US Clinical Trial NCT03842423 – NIH – Feb 13, 2019

Brachial Plexus Block in Children and Adolescents Requiring Surgery Following Trauma

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US Clinical Trial NCT03842540 – NIH – Feb 13, 2019

The Share Health Study: Teens Social Connections and Health (Phase 2)

Teen pregnancy results from under-use contraception by sexually active teens. Social networks are important influences on teen contraceptive knowledge and use. Encouraging social communication to increase knowledge and acceptability of LARC among fe...
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US Clinical Trial NCT03842878 – NIH – Feb 13, 2019

Prospective, Longitudinal Study of the Natural History and Functional Status of Patients With Limb-Girdle Muscular Dystrophy 2I

Study duration Duration from FPFV to LPLV : 3 years Study objectives Primary objective: To characterize the disease course in Limb-Girdle Muscular Dystrophy 2I (LGMD2I) patients using standardized and disease appropriate evaluations. Secondary ob...
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US Clinical Trial NCT03842982 – NIH – Feb 13, 2019

Phase III Randomized Clinical Trial Evaluating Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer Considering Two Different Settings: Primary Debulking Surgery (PDS) and Interval Debulking Surgery (IDS)

The primary objective of this study is to assess the efficacy, in terms of disease-free survival (DFS), the use of HIPEC treatment combined with standard care (PDS or IDS) or standard care alone (PDS or IDS alone). Secondary objectives of the study...
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