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US Clinical Trial NCT03982030 – NIH – Jun 10, 2019

An Open-label, Pilot Clinical Trial of Dalbavancin for the Treatment of Susceptible Gram-positive Infections Requiring Prolonged Intravenous Antibiotic Therapy

A phase 4, single-center, pilot open-label trial assessing the safety and efficacy of dalbavancin in the outpatient therapy of susceptible gram-positive infections requiring prolonged intravenous therapy.
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US Clinical Trial NCT03982732 – NIH – Jun 10, 2019

Maternal Antibody in Milk After Vaccination

Pertussis disease is a highly infectious respiratory illness caused by Bordetella pertussis, which can cause significant morbidity and mortality. There has been an increase in cases in many high income countries with high vaccination coverage and in...
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US Clinical Trial NCT03982394 – NIH – Jun 10, 2019

Multi-Country Prospective ObserVAtionaL, Cohort Study of Patients With Moderate to Severe Chronic PlaqUE Psoriasis (VALUE)

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US Clinical Trial NCT03982589 – NIH – Jun 10, 2019

Telomere Length in Relation to Acute Stress Response in Critical Care Patients

Telomeres length analysis were determined from 2 blood samples, the initial sample drawn in the first 72 hours after hospitalization and the second after not < 5 or > 14 days. For patients discharged before day 5, a repeat sample was drawn and...
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US Clinical Trial NCT03981848 – NIH – Jun 10, 2019

Radiomics-based Non-invasive Classifier Research for HCC-related Liver Transplantation

Hepatocellular carcinoma is one of the most common malignant tumors in the world with high incidence and mortality. Liver transplantation is the most effective treatment for HCC and is in high demand in China. However, recurrence of HCC among liver...
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US Clinical Trial NCT03982056 – NIH – Jun 10, 2019

"Float First": Categorising Factors Effecting Floating in Different Populations During Water Immersion.

Between 2000 and 2013 an average of 425 people in the UK drowned per annum, and a reported 100,000 people were involved in water-related emergencies involving search and rescue services. Approximately half had not intended to go into the water. Rese...
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US Clinical Trial NCT03982186 – NIH – Jun 10, 2019

A Phase 2b, Multicenter, Double-blind, Active-controlled, Randomized Study to Investigate the Efficacy and Safety of Different Combination Regimens Including JNJ-73763989 and/or JNJ-56136379 for the Treatment of Chronic Hepatitis B Virus Infection

Hepatitis B virus (HBV) is a small deoxyribonucleic acid virus that specifically infects the human liver. The acute phase of infection is either followed by an immune controlled state or progresses to chronic hepatitis B. The worldwide estimated pre...
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US Clinical Trial NCT03982199 – NIH – Jun 10, 2019

A Randomized, Double-blind, Placebo-controlled Phase 2b Study to Assess the Efficacy, Immunogenicity and Safety of an Ad26.RSV.preF-based Regimen in the Prevention of RT PCR-confirmed RSV-mediated Lower Respiratory Tract Disease in Adults Aged 65 Years and Older

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US Clinical Trial NCT03982472 – NIH – Jun 10, 2019

Shoulder Transcutaneous Electric Nerve Stimulation Decelerates Heart Rhythm of Subjects Via Potentiating Vagal Tone

Study design This study complied with the Declaration of Helsinki, and all protocols were approved by the ethics committee of Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan. All the participants gave written informed conse...
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US Clinical Trial NCT03982303 – NIH – Jun 9, 2019

A Dose Escalation Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Antitumor Efficacy of Hemay102 in Patients With Advanced Solid Tumors

Dose escalation: A total of 7 dosage groups were set at this stage, which were 5 mg/m2, 10 mg/m2, 20 mg/m2, 40 mg/m2, 60 mg/m2, 90 mg/m2, and 120 mg/m2, respectively. Accelerated dosage titration was performed in the first 3 dose groups, 1 subject...
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US Clinical Trial NCT03982238 – NIH – Jun 9, 2019

Effects of Continuous Subcutaneous Insulin Infusion and Oral Hypoglycemic Drugs on Testosterone Levels in Type 2 Diabetes Patients

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US Clinical Trial NCT03982498 – NIH – Jun 9, 2019

Diagnostic Accuracy of Increased Serum Cytokine Levels as a Marker of Paralytic Ileus Following Robotic Radical Cystectomy

Cytokines are signalling proteins that are release by immune cells in response to stress on the body. In this study the aim is to evaluate the concordance between cytokine rise (specifically monitoring the following cytokines: Interferon (IFN)-gamma...
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US Clinical Trial NCT03982524 – NIH – Jun 8, 2019

Enriching Cognitive-Behavioral Therapy With Emotion Regulation Training in Patients With Chronic Multiple Somatoform Symptoms (ENCERT): A 3-Year Follow-up of a Randomized Controlled Trial

Somatic symptoms not caused by a known biomedical condition ("somatoform disorders") are highly prevalent, involve a high risk of chronicity, are one of the major reasons for doctor visits, and are a tremendous burden for health care systems. Despit...
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US Clinical Trial NCT03982316 – NIH – Jun 8, 2019

Telehealth Behavioral Migraine Management

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US Clinical Trial NCT03982667 – NIH – Jun 8, 2019

Research Title: Efficacy and Safety of Point- Of-care Procalcitonin Test to Reduce Antibiotic Exposure in Ventilator Associated Pneumonia (VAP) Patient in ICU: A Randomised Controlled Trial

Pneumonia remains one of the major cause of morbidity and mortality in critically ill patients in the intensive care unit (ICU) worldwide. In Malaysia, according to the Malaysian Registry of Intensive Care 2016, pneumonia was among the four (5.7%) m...
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US Clinical Trial NCT03980665 – NIH – Jun 7, 2019

The Effect of Arsenic Trioxide on Eliminating HIV-1 Reservoir Combined With cART

Although combined antiretroviral therapy (cART) could control human immunodeficiency virus type 1 (HIV-1) infection, the persistence of HIV-1 viral reservoir make it extremely difficult to achieving cure of AIDS. The shock and kill strategy has been...
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US Clinical Trial NCT03981510 – NIH – Jun 7, 2019

Comparison of Gastrointestinal Motility in Healthy Children and Children With Constipation

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US Clinical Trial NCT03981614 – NIH – Jun 7, 2019

Combination of MEK Inhibitor Binimetinib and CDK4/6 Inhibitor Palbociclib in KRAS and NRAS Mutant Metastatic Colorectal Cancers

PRIMARY OBJECTIVES: I. The primary objective is to compare the progression-free survival (PFS) between those randomized to palbociclib/binimetinib and those randomized to trifluridine and tipiracil hydrochloride (TAS-102) in patients with refractor...
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US Clinical Trial NCT03981653 – NIH – Jun 7, 2019

Angiogenic Function at Normal Term on Placenta

The objective of this study is to better understand the regulation of trophoblast expression of pro- and antiangiogenic factors such as placenta growth factor (PlGF) or Soluble FMS like tyrosin-kinase-1 (sFlt-1), and more particularly on human diffe...
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US Clinical Trial NCT03981770 – NIH – Jun 7, 2019

Characterisation of Gut Microbiota, Bispectral Index Data and Plasma Kynurenine in Patients Undergoing Thyroid Surgery

The study is a case-controlled observational trial. Forty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data. Firstly, this study aims to characterise the lung microbiota...
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US Clinical Trial NCT03981913 – NIH – Jun 7, 2019

Study of the Neuronal Substrates of the Cognitive Action Control in Parkinson's Disease Using High Density EEG

Alterations in cognitive action control in patients with PD are well described from a behavioral point of view. However, there is currently very little information to directly link these difficulties to functional alterations of brain areas, or of e...
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US Clinical Trial NCT03981952 – NIH – Jun 7, 2019

Phase 1/2a Randomized, Placebo-Controlled, Dose-Escalation Study of the Safety, Reactogenicity, and Immunogenicity of Trivalent (S. Enteritidis/S. Typhimurium/S. Typhi Vi) Conjugate Vaccine Against Invasive Salmonella Disease Administered Parenterally to Healthy U.S. Adults

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US Clinical Trial NCT03981991 – NIH – Jun 7, 2019

Assessment of the Quality of Life for Patients Suffering From Isolated Endometriosic Lesion of Utero-sacral Ligaments Diagnosed by MRI, Before and After Surgical Treatment by Using French Version of Endometriosis Health Profile 30 (EHP30)

Endometriosis is a gynecological pathology affecting women during periods of genital activity, which prevalence is underestimated and varies from 10 to 30%. It is characterized by dysmenorrhea, dyspareunia, chronic pelvic pain or infertility. These...
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US Clinical Trial NCT03982173 – NIH – Jun 7, 2019

A Phase II Whole Exome Secquencing-based Basket Trial for Combination Therapy With Durvalumab (Anti-PDL1) (MEDI4736) and Tremelimumab (Anti-CTLA4) in Patients With Metastatic Solid Tumors

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US Clinical Trial NCT03980964 – NIH – Jun 7, 2019

Prospective Evaluation of Neuromuscular Electrical Stimulation (NMES) for Reducing Pain and Improving Functional Outcomes in Knee Osteoarthritis (OA) Patients

The study will be conducted at Lenox Hill Hospital, Northwell Health, located in New York, New York, and involve a total of 120 patients. All study patients will be evenly divided into two groups: (a) conductive garment and mobile app with NMES ther...
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US Clinical Trial NCT03981718 – NIH – Jun 7, 2019

Adipose-Induced Regeneration of Breast Skin (AIR Breast) to Treat Post-Mastectomy Radiation Injury in Breast Cancer Patients: A Randomized, Prospective Pilot Study

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US Clinical Trial NCT03981965 – NIH – Jun 7, 2019

Impact of FOCUS Guidelines on Adherence to Physical Activity in Ageing Women.

The objectives of the study consisted of assessing i) whether the use of the Guidelines derived from the European project FOCUS had an effect on the adherence to a physical activity (PA) program (primary objective), and ii) the effect of the program...
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US Clinical Trial NCT03981978 – NIH – Jun 7, 2019

Validity of Physical Activity Questionnaires in Persons Pursuing Bariatric Surgery

This cross-sectional study will collect subject's medical history, anthropometric measurements, physical activity data through an accelerometer worn on the wrist and indirect physical activity measures via the Human Activity Profile and Godin self-r...
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US Clinical Trial NCT03982043 – NIH – Jun 7, 2019

Text2Connect, Component 2 of iCHART (Integrated Care to Help At-Risk Teens)

Text2Connect (T2C) aims to increase perceived susceptibility/severity of depression/suicidality and decrease stigma in at-risk adolescents and their parents. The investigators hypothesize that modification of patient beliefs leads to change talk, th...
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US Clinical Trial NCT03982680 – NIH – Jun 7, 2019

Clinical Study of Toripalimab Monoclonal Antibody Combined With Gemcitabine/5--fluoropyrimidine in the Treatment of Advanced Cholangiocarcinoma

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US Clinical Trial NCT03980691 – NIH – Jun 7, 2019

Effect of Chidamide Combined With CAT-T or TCR-T Cell Therapy on HIV-1 Latent Reservoir

Despite the advent of combined antiretroviral therapy (cART), the persistence of viral reservoirs remains a major barrier to cure human immunodeficiency virus type 1 (HIV-1) infection. Recently, the shock and kill strategy, by which such reservoirs...
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US Clinical Trial NCT03981627 – NIH – Jun 7, 2019

A Randomized, Single-centre, Double-blind, 2-period Cross-over Trial to Assess Safety and Efficacy of ADO09 Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus

After a screening visit, eligible subjects will enter a run-in period. Subjects will receive a Continuous Glucose Monitoring (CGM) system for glucose monitoring and control at the beginning of the run-in and for the whole duration of the study. Each...
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US Clinical Trial NCT03981705 – NIH – Jun 7, 2019

Assessment of Complete Pathologic Response After Neoadjuvant Chemotherapy for Breast Cancer

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US Clinical Trial NCT03981861 – NIH – Jun 7, 2019

Metabolic and Neuro-Endocrine Effect of Treating PCOS in Adolescents

Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in adolescent females and also one of the most complex. Patients experience an exaggerated ovarian/adrenal androgen production in response to physiologic and supra-physiologic elev...
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US Clinical Trial NCT03981926 – NIH – Jun 7, 2019

Team-Based Connected Health (TCH) to Improve Clinical Outcomes and Access in Atopic Dermatitis

Skin diseases account for 30% of all physician office visits. In the United States, access to dermatologists remains a significant challenge for those in underserved or rural communities. To increase access to specialists and improve patient outcome...
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US Clinical Trial NCT03981939 – NIH – Jun 7, 2019

Perianal Fistula Procedure Validation, Matched Case Control, and Patient Journey Study

This is a retrospective follow-up observational study of participants with CD with and without PAF from January 2002 to March 2017. The study will verify the potential of using procedure codes to reliably identify participants with PAF in Validation...
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US Clinical Trial NCT03982719 – NIH – Jun 7, 2019

Randomized Controlled Trial Comparing the Effectiveness of Two Post-fasciectomy Rehabilitation Protocols Differing in Intensity and Implementation of Modalities in Patients With Dupuytren's Disease

Dupuytren's disease can cause physical impairments that lead to reduced functional performance in personal care, work-related and leisure activities. The prevalence of Dupuytren's disease increases with age. A meta-analysis completed in 2014 by Lant...
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US Clinical Trial NCT03980899 – NIH – Jun 7, 2019

Valuation of the Long-term Tolerance of Proton Pump Inhibitor (PPI) Discontinuation in Geriatric Patients Treated With Long-term Therapy Without a Recognized Indication

Professor Sylvie Legrain, in a 2005 HAS report, described that "Better prescribing in the elderly is thus a public health issue. "Indeed, although multi-medication in the elderly is often justified, it increases the risk of drug iatrogeny, reduces c...
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US Clinical Trial NCT03980925 – NIH – Jun 7, 2019

A Phase II Study of Platinum-doublet Chemotherapy in Combination With Nivolumab as First-line Treatment in Subjects With Unresectable, Locally Advanced or Metastatic G3 Neuroendocrine Neoplasms (NENs) of the Gastroenteropancreatic (GEP) Tract or of Unknown (UK) Origin.

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US Clinical Trial NCT03981380 – NIH – Jun 7, 2019

11C-PIB PET Study in the Multi Ethnic Study of Atherosclerosis at Columbia University

This is a single center PET study of 11C-PIB. Eligible participants are current participants in the MESA study in New York City, without contraindications to MRI or PET procedures. Those eligible will have one brain PET scan with 11C-PIB within 12 m...
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US Clinical Trial NCT03981692 – NIH – Jun 7, 2019

The Effect of Different Dual Task Training Programs on the Balance, Fear of Fall and Quality of Life in Geriatric Individuals

For the purpose, the number of 42 participants reached by the power analysis method was determined as 60 people considering the possible separations. 60 participants will be included in the study. Participants should not have any orthopedic, neurolo...
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US Clinical Trial NCT03981731 – NIH – Jun 7, 2019

Management of Perioperative Stress by the Cardiac Coherence Technique Coupled With a Hypnosis Session, as Part of the Improved Pre-habilitation After Surgery.

The perioperative period is recognized as an anxiety-provoking period for patients. If for some patients, this anxiety is more or less manageable, for others, it is the major concern with regard to their intervention, fearing not to wake up, to rema...
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US Clinical Trial NCT03981744 – NIH – Jun 7, 2019

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatments

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US Clinical Trial NCT03981783 – NIH – Jun 7, 2019

Comprehensive Health Informatics Engagement Framework for Pulmonary Rehab

Previous studies clearly established clinical benefits of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) however uptake and completion rate of pulmonary rehabilitation (PR) programs by these patients is limite...
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US Clinical Trial NCT03982017 – NIH – Jun 7, 2019

Heart Failure Self-care Mobile Application to Reduce Readmissions Trial

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US Clinical Trial NCT03980938 – NIH – Jun 7, 2019

A Double-Blind, Placebo-Controlled Two-Period 10-Week Treatment Within-Subject Crossover Study Of Cognitive Effects Of Neflamapimod in Early-Stage Huntington Disease (HD)

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US Clinical Trial NCT03981666 – NIH – Jun 7, 2019

Systematic Self-screening of Insomnia and Proposition of a Video-Based Cognitive Behavioral Therapy for Insomnia in Adults Cancer Patients and Survivors: A Pilot Study

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US Clinical Trial NCT03981679 – NIH – Jun 7, 2019

Prospective, Non-randomized, Open-label and Multi-center Study With the Establishment of a Clinical-biological Database.

Colorectal cancer (CRC): is one of the most frequent cancers, with almost 42152 new cases estimated in France for 2012. The incidence is thus 30 new cases per year per 100 000 inhabitants in France. It is also a significant cause of death, with 10 d...
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US Clinical Trial NCT03981874 – NIH – Jun 7, 2019

Comparative Study of Peripheral Facial Paralysis Sequelae Based on the Initial Medical Care of Lyme Disease Among Children

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US Clinical Trial NCT03981900 – NIH – Jun 7, 2019

IDentification of Predictive Factors of Continuation of Treatment With Tofacitinib in Patients With Rheumatoid Arthritis in Common Practice and the Impact of the Patient's Behavioural Strategies on Clinical Parameters: The DeFacTo Study.

This is an observational, open-label, prospective, multi-centre, national study designed to evaluate the factors predictive of Tofacitinib's survival in patients with rheumatoid arthritis If catastrophisation is described as a distortion of the per...
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