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US Clinical Trial NCT03908775 – NIH – Apr 8, 2019

A Comparison of C-MAC Videolaryngoscopy and Direct Laryngoscopy for Nasotracheal Intubation in Children: A Randomized, Controlled Clinical Trial

Tracheal intubation using direct laryngoscopy is successful in the majority of patients, even when a line-of-sight view of the glottis is not possible. Although poor glottic visualization is encountered between 1% and 9% of attempts, success can gen...
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US Clinical Trial NCT03909087 – NIH – Apr 8, 2019

The Impact of Electroacupuncture on Clinical Effect,Brain Structural and Functional Changes in Patients With Spinal Cord Injury:A Randomized Controlled Study Based on Multi-mode Magnetic Resonance Imaging.

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US Clinical Trial NCT03909165 – NIH – Apr 8, 2019

A Phase 4 Double-blinded, Randomized, Active Comparator-controlled Clinical Trial to Study the Efficacy, Safety, and Pharmacokinetics of Sugammadex (MK-8616) for Reversal of Neuromuscular Blockade in Pediatric Participants Aged Birth to <2 Years

This trial will be conducted in two parts: Part A and Part B. In Part A, PK sampling will be conducted to identify the pediatric dose providing sugammadex exposure similar to adults. For Part B participants, the efficacy of sugammadex (i.e. time to...
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US Clinical Trial NCT03907488 – NIH – Apr 8, 2019

A Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma

PRIMARY OBJECTIVES: I. To compare the progression-free survival (PFS) in patients with newly diagnosed advanced stage classical Hodgkin lymphoma randomized to N-AVD (nivolumab, doxorubicin hydrochloride [doxorubicin], vinblastine sulfate [vinblasti...
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US Clinical Trial NCT03908645 – NIH – Apr 8, 2019

Development and Validation of a Deep Learning Algorithm for Bowel Preparation Quality Scoring

Colonoscopy is recommended as a routine examination for colorectal cancer screening. Adequate bowel preparation is indispensable to ensure a clear vision of colonic mucosa,complete inspection of all colon segments, and furthermore improves the dete...
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US Clinical Trial NCT03908671 – NIH – Apr 8, 2019

Clinical Trial on the Safety and Efficacy of Neoantigen Antigen mRNA Tumor Vaccine in the Treatment of Advanced Esophageal Cancer and Non-small Cell Lung Cancer

Primary objectives: Assessing the safety and tolerability of mRNA personalized tumor vaccines encoding neoantigen for unresectable or metastatic advanced esophageal and non-small cell lung cancers with standard treatment failure or no standard trea...
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US Clinical Trial NCT03908762 – NIH – Apr 8, 2019

Use of a Digital Therapeutic and Connected Devices to Support Insulin Titration

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US Clinical Trial NCT03908905 – NIH – Apr 8, 2019

Prevalence of Sleep Disturbances in Individuals With Chronic Widespread Pain

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US Clinical Trial NCT03909152 – NIH – Apr 8, 2019

Basket Study of the Oral Progesterone Antagonist Onapristone ER (Apristor) in Women With Progesterone Receptor Positive (PR+) Recurrent Granulosa Cell Tumor, Low Grade Serous Ovarian Cancer or Endometrioid Endometrial Cancer

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US Clinical Trial NCT03908684 – NIH – Apr 8, 2019

Pilot Investigation of Ultrasound Cell Death Imaging and Spectroscopy as Early Indicators of Response to Radiation Treatment in Prostate, Rectum and Head and Neck Cancers, and to Characterize Prostate Masses

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US Clinical Trial NCT03908814 – NIH – Apr 8, 2019

Phase I Clinical Trial to Evaluate the Safety, Tolerance and Pharmacokinetics of Whole Human Anti-PD-L1 Antibody Injection (LDP) in Patients With Advanced Malignant Tumors

This trial is an open, dose escalation phase I clinical trial study of patients with advanced cancer who have failed standard treatment. The trial is divided into a dose escalation phase and an expansion phase. Approximately 130 patients will be en...
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US Clinical Trial NCT03908749 – NIH – Apr 7, 2019

A Real-world Clinical Study of Pyrotinib Maleate Tablets in the Treatment of Breast Cancer Patients With Positive Her-2

This study intends to carry out multicenter, observational cohort clinical research, using maleic acid pyrrole for his piece of HER-2 positive treatment of advanced breast cancer treatment, observation and verification maleic acid pyrrole for his pi...
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US Clinical Trial NCT03908827 – NIH – Apr 7, 2019

The Effectiveness of Bone Marrow Aspirate Concentrate (BMAC) in Patients With Severe Hip or Knee Osteoarthritis Awaiting Arthroplasty - A Randomized Controlled Trial

This is a randomized controlled trial. In cooperation with Alberta Bone and Joint Health Institute (ABJHI), patients who have been deemed to be hip or knee joint arthroplasty candidates at the time of the initial assessment by the ABJHI musculoskele...
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US Clinical Trial NCT03908866 – NIH – Apr 7, 2019

Peripherally Inserted Versus Centrally Inserted Central Venous Catheters in the Neurosurgical Intensive Care Unit. Comparative of Cost-Effectiveness and Safety

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US Clinical Trial NCT03908541 – NIH – Apr 7, 2019

Peripheral Inflammation and Brain Structural Alterations in Patients With Disorders of Consciousness.

Background: Systemic inflammation, neurocognitive impairments, and morphologic brain changes are associated with outcome in patients with disorder of consciousness. Objective: The aim of this study is to assess the value of peripheral inflammatory...
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US Clinical Trial NCT03908723 – NIH – Apr 7, 2019

Treatment of Macular Edema Caused by Leber's Miliary Aneurysms Using Intravitreal Aflibercept and Peripheral Laser Photocoagulation

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US Clinical Trial NCT03908970 – NIH – Apr 7, 2019

A Multicenter, Randomized, Double-blind, Vehicle Controlled, Parallel-group Comparison Trial to Demonstrate the Superiority of 1% OPA-15406 Ointment to the Vehicle in Adult Patients With Atopic Dermatitis (Phase 3 Trial)

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US Clinical Trial NCT03909061 – NIH – Apr 7, 2019

Effectiveness of a Remote Wheelchair Maintenance Training Program

Up to 100 individuals will be recruited for this research study. We will recruit individuals who use a wheelchair for the majority of their mobility (over 40 hours per week), and have a traumatic spinal cord injury (SCI). This study will be accessed...
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US Clinical Trial NCT03908710 – NIH – Apr 7, 2019

A Prospective Trial of Home Blood Pressure Levels in Hypertensive Participants Using the ACCUMBO Telemedicine Device

Despite the extensive knowledge of the importance of treating and thus preventing complications of hypertension, the incidence of high blood pressure is increasing, and it is still the main cause of cardiovascular disease and premature death, partly...
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US Clinical Trial NCT03907579 – NIH – Apr 6, 2019

Screen to Save: A Colorectal Cancer Educational Intervention

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US Clinical Trial NCT03907605 – NIH – Apr 6, 2019

Comparison of Serum Anti-Mullerian Hormone Levels Following Uterine Artery Ligation for PPH.

All patients belong to the same group. The blood samples will be collected at the time of surgery and 3 months after surgery from the patients who need uterine artery ligation for PPH. The blood samples will be centrifuged within 2 hours after being...
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US Clinical Trial NCT03908203 – NIH – Apr 6, 2019

Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction

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US Clinical Trial NCT03908359 – NIH – Apr 6, 2019

Comparison of the Effect of Minimal Invasive Lens Surgery and Traditional Cataract Surgery for Treating Congenital Cataracts

Patients with congenital cataract that requires surgical intervention are enrolled. Then the patients are assigned to two groups: Group I: the participants receive a minimal invasive lens surgery, while in Group II, the participants receive a tradi...
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US Clinical Trial NCT03907618 – NIH – Apr 6, 2019

Evaluation of HbA1c Levels and Ovarian Reserve in Patients With Type 1 Diabetes Diagnosis

The study was designed prospectively. Ovarian functions in healthy volunteer women and patients who use DM1 diagnosed between 18-40 years old will be examined. Gonadotropin and AMH levels will be measured in follicular phase. To calculate the number...
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US Clinical Trial NCT03907592 – NIH – Apr 6, 2019

Effect of Carnitine Supplementation and Resistance Training on Skeletal Muscle Function in Aging

The study will be included volunteers - women between 60 - 72 years old (n=60). The patients are randomly assigned to two experimental groups (n=20) and control group (n=20). During the 24-weeks intervention period, Group A undergoes training proced...
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US Clinical Trial NCT03908216 – NIH – Apr 6, 2019

Evaluation of Non-drug and Drug Treatment of oVerweight and Obesity in pAtients With Cardiovascular Diseases or With High Cardiovascular Risk According to Patient Survey Data, in the Framework of the Outpatient Register PROFILE (EVA)

To conduct a survey of 300 patients with a BMI≥25 kg / m² of the outpatient register, who come for a primary or return visit to the Center. The original questionnaire includes information on self-assessment and patient awareness of the presence of o...
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US Clinical Trial NCT03908229 – NIH – Apr 6, 2019

TRAINEE PARTICIPATION INCREASES COLON ADENOMA DETECTION RATE: A RANDOMIZED CONTROLLED TRIAL

Background Colonoscopy is instrumental in colon cancer prevention as through polypectomy it may interfere with the adenoma-carcinoma sequence, thus resulting in a clear survival benefit. However, not all adenomatous polyps are identified during a c...
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US Clinical Trial NCT03908242 – NIH – Apr 6, 2019

Randomized, Double-blind, Placebo-controlled, Continuous Dosing, Single-center, Evaluation of Safety, Tolerability, and Pharmacokinetic Properties of Salvianolic Acid A Tablets in Healthy Volunteers

This was a Phase I repeated incremental doses study in healthy volunteers. A total of 24 subjects was planned to be enrolled. This was performed according to a double blind, randomized, placebo controlled design and included two sequential dose grou...
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US Clinical Trial NCT03908606 – NIH – Apr 6, 2019

Prognostic Value of Serum Hs-CRP in Periodontitis Patients With or Without Type 2 Diabetes Following Non-surgical Periodontal Therapy

Periodontitis and diabetes are chronic disorders with a two-way correlation as they can both stimulate an inflammatory response with subsequent formation of inflammatory mediators and cytokines. C reactive protein is an inflammatory plasma marker ha...
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US Clinical Trial NCT03906058 – NIH – Apr 5, 2019

Open-Label, Phase Ⅱ Study of Anlotinib Treatment in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma After Failure of no Less Than Second-line Chemotherapy or Targeted Therapy

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US Clinical Trial NCT03906812 – NIH – Apr 5, 2019

A Randomized Trial of Telemetry Compared With Unmonitored Floor Admissions in ED Patients With Low-Risk Chest Pain

Many patients admitted to the hospital with concern for cardiopulmonary and other acute illnesses are routinely placed on electrocardiographic monitoring (telemetry). Telemetry surveillance theoretically allows the clinical staff to monitor admitted...
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US Clinical Trial NCT03907033 – NIH – Apr 5, 2019

Preemptive Local Analgesia With Liposomal Bupivacaine in Vaginal Hysterectomy: A Randomized Controlled Study

Prior to surgery, patients are assigned by chance (like a coin toss) to receive either the bupivacaine HCl injection at the time of surgery or bupivacaine HCl plus liposomal bupivacaine. Patients and the Principal Investigator cannot choose the stud...
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US Clinical Trial NCT03907280 – NIH – Apr 5, 2019

Absolute Bioavailability of BI 1265162 Following Oral and Inhaled Administration in Healthy Male Volunteers (an Open-label, Randomised, Single-dose, Three-period, Three-sequence Crossover Study)

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US Clinical Trial NCT03907423 – NIH – Apr 5, 2019

Effects of Rosuvastatin on Markers of Atherosclerosis in Diabetic Patients Treated With Glimepiride/Metformin Combination

A randomized controlled trial on 60 patients with DM type 2 will be recruited from Damanhour national medical institute. - Subjects will be divided into two group (one arm is DM-type 2 patients who will receive rosuvastatin -metformin-glimepiride c...
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US Clinical Trial NCT03907566 – NIH – Apr 5, 2019

The Turkish Version of the Oropharyngeal Dysphagia Screening Test for Patients and Professionals

The purpose of this study is to test the reliability and validity of the The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals among adult patients with swallowing disorders.The internal consistency, test-retest reliabili...
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US Clinical Trial NCT03907670 – NIH – Apr 5, 2019

Clinical and Immunological Outcome in Chronic Myloid Leukemic Patients Treated With Tyrosine Kinase Inhibitor: Assuit University Hospitals Insight

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder in which leukemic cells display the Philadelphia chromosome generated from a reciprocal t(9:22) (q34:q11) translocation.1 The chromosome 9 and chromosome 22 transposal of t (9:22) a...
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US Clinical Trial NCT03907735 – NIH – Apr 5, 2019

Oxytocin Receptor Expression in Pregnancy: When Does it Turn on

In this descriptive study, we will obtain myometrial tissue samples by core needle biopsy under ultrasound guidance in anesthetized women immediately following surgical abortion and from controls, all of whom are undergoing a separate planned obstet...
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US Clinical Trial NCT03908333 – NIH – Apr 5, 2019

Phase IB/II Trial of High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have No Prior Therapy for Their Metastatic Pancreatic Cancer

Pancreatic cancer continues to be a very lethal disease. It was estimated that in 2016, 53,070 Americans would be diagnosed with pancreatic ductal adenocarcinoma (PDA), and 41,780 would die from the disease. This makes pancreatic cancer the third le...
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US Clinical Trial NCT03908515 – NIH – Apr 5, 2019

Multi-center Clinical Observation of FCVB in Guangdong Province

1. Research purpose: Collect and analyze the medical data in clinical work, in order to provide further theoretical guidance for the clinical application of FCVB. 2. Inclusion criteria: 1) Patients with severe retinal detachment, cannot be cured wi...
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US Clinical Trial NCT03908593 – NIH – Apr 5, 2019

Evaluation of the Efficacy of Different Duration of a Proton Pump Inhibitor in the Prevention of Upper Gastrointestinal Mucosal Injury in Patients Taking 12-month Dual Antiplatelet Therapy After Coronary Artery Bypass Grafting

A single-center, open-label, randomized controlled trial to compare the efficacy of 12 months and 1 month of pantoprazole treatment for the prevention of upper gastrointestinal mucosal injury in patients on DAPT after CABG. 13C urea breath testing (...
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US Clinical Trial NCT03906565 – NIH – Apr 5, 2019

Open, Multicenter, Monotherapy, Phase II Clinical Study of Utidelone Injection in Patients With Advanced or Metastatic Colorectal Cancer After Failure or Intolerability to Second-line Standard Treatment

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US Clinical Trial NCT03906578 – NIH – Apr 5, 2019

Effect of a Probiotic on Blood Pressure in Low-to-moderate Risk Grade 1 Hypertension - a Randomized Study

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US Clinical Trial NCT03906630 – NIH – Apr 5, 2019

Comparison of the Accuracy of Telehealth Examination Versus Clinical Examination in the Detection of Rotator Cuff Tears

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US Clinical Trial NCT03907059 – NIH – Apr 5, 2019

Does Exclusive Consumption of Plant-based Dietary Protein Impair Resistance Training-induced Muscle Adaptations?

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US Clinical Trial NCT03907072 – NIH – Apr 5, 2019

A Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of WVE-210201 in Ambulatory Patients With Duchenne Muscular Dystrophy

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US Clinical Trial NCT03907449 – NIH – Apr 5, 2019

Preview Rapid Strep A Test Method Comparison Study

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US Clinical Trial NCT03907527 – NIH – Apr 5, 2019

Phase I Study Evaluating Benefit of PRGN-3005 UltraCAR-T™ (Autologous CAR T Cells) in Advanced Stage Platinum Resistant Ovarian Cancer Patients

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US Clinical Trial NCT03907540 – NIH – Apr 5, 2019

Open-label, Two-part Study Designated to Assess the Absolute Bioavailability of KD025 and to Determine the Mass Balance Recovery, Metabolite Profile and Identification of Metabolite Structures for [14C]-KD025 in Healthy Male Subjects

An open-label, two-part study designed to assess the absolute bioavailability of KD025 and to determine the mass balance recovery, metabolite profile and identification of metabolite structures for [14C]-KD025 in healthy male subjects
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US Clinical Trial NCT03907683 – NIH – Apr 5, 2019

Phase 1 Clinical Trial to Develop a Personalized Adaptive Text Message Intervention Using Control Systems Engineering Tools to Increase Physical Activity in Early Adulthood

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US Clinical Trial NCT03907696 – NIH – Apr 5, 2019

Reducing Stigma Towards Psychiatry Among Medical Students: a Multicenter Controlled Trial

Design and participants- This study used a controlled trial design. The study population consisted of medical students during their six-week psychiatry clerkship. The study was conducted between November 2017 and July 2018 in eight academic hospital...
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