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US Clinical Trial NCT00004640 – NIH – Sep 17, 1999

Trials to Enhance Elders' Teeth and Oral Health

"TEETH" is a double-blinded, randomized clinical trial, supervised by a Data & Safety Monitoring Board, designed to provide unequivocal evidence regarding the impact of regular rinsing 0.12% chlorhexidine solution on tooth loss in low income, co...
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US Clinical Trial NCT00004639 – NIH – Sep 17, 1999

Velopharyngeal Function for Speech After Palatal Surgery

This study is conducted with patients with complete unilateral cleft lip and palate. The subjects will have their palatal clefts surgically repaired by either the von Langenbeck or the Furlow double z-plasty palatoplasty. Patients will be randomly a...
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US Clinical Trial NCT00000206 – NIH – Sep 20, 1999

Clinical Rescue Protocol

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US Clinical Trial NCT00000214 – NIH – Sep 20, 1999

IV Cocaine Abuse: A Laboratory Model

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US Clinical Trial NCT00000226 – NIH – Sep 20, 1999

Alternate-Day Buprenorphine Administration. Phase VII

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US Clinical Trial NCT00000229 – NIH – Sep 20, 1999

Buprenorphine Detox With Two Types of Treatment. BBD II

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US Clinical Trial NCT00000233 – NIH – Sep 20, 1999

Alternate Day Buprenorphine Administration, Phase X

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US Clinical Trial NCT00000235 – NIH – Sep 20, 1999

Alternate Day Buprenorphine Administration, Phase XII

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US Clinical Trial NCT00000254 – NIH – Sep 20, 1999

Isoflurane at Subanesthetic Concentrations

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US Clinical Trial NCT00000256 – NIH – Sep 20, 1999

Reinforcing Effects of Brief Exposures to Nitrous Oxide

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US Clinical Trial NCT00000257 – NIH – Sep 20, 1999

Effects of Alcohol History on Effects of Nitrous Oxide

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US Clinical Trial NCT00000258 – NIH – Sep 20, 1999

Role of Instructions in Nitrous Oxide Effects and Choice

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US Clinical Trial NCT00000264 – NIH – Sep 20, 1999

Subjective/Psychomotor/ Effects of Combined Alcohol & Nitrous Oxide

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US Clinical Trial NCT00000266 – NIH – Sep 20, 1999

Flupenthixol Treatment in Schizophrenic Cocaine Abusers

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US Clinical Trial NCT00000273 – NIH – Sep 20, 1999

A Laboratory Model for Heroin Abuse Medications

Abuse of prescription opioid medications has increased dramatically in the U.S. during the past decade, as indicated by a variety of epidemiological sources. However, few studies have systematically examined the relative reinforcing effects of commo...
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US Clinical Trial NCT00000279 – NIH – Sep 20, 1999

Novel Medications for Opiate Detoxification

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US Clinical Trial NCT00000282 – NIH – Sep 20, 1999

Pemoline for Cocaine Abuse

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US Clinical Trial NCT00000293 – NIH – Sep 20, 1999

Effect of Nefazodone on Relapse in Females With Cocaine Abuse

The purpose of this study is to determine the effect of nefazodone on relapse to cocaine in women and if a greater effect will be seen in the dependent condition. A relapse and coping skills questionnaire will be utilized to determine the various fa...
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US Clinical Trial NCT00000302 – NIH – Sep 20, 1999

Expanded Steady-State Pharmacokinetic Study, Comparing Liquid and Tablet Buprenorphine Formulations

Participants were inducted on either liquid or tablet buprenorphine, in a double-blind, double-dummy manner. They each reached a steady state by the second week, and were scheduled to have blood draws in weeks 3, 4, 7, 8, 11, 12, 15, and 16.
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US Clinical Trial NCT00000304 – NIH – Sep 20, 1999

Dextroamphetamine as an Adjunct in Cocaine Treatment

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US Clinical Trial NCT00000310 – NIH – Sep 20, 1999

Serotonin/Dopamine Antagonism of Cocaine Effect

Risperidone in low doses is compared with placebo in a 6-week randomized trial. Subjects also receive supportive counseling. Outcome measure include rating of behavior, mood, drug abuse, global function, and urine toxicology.
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US Clinical Trial NCT00000311 – NIH – Sep 20, 1999

Combining Behavioral Treatment With Agonist Maintenance

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US Clinical Trial NCT00000317 – NIH – Sep 20, 1999

Early Phase II Trials for Cocaine Medication Development

This was an 18-week prospective, randomized, placebo-controlled crossover design with placebo lead-in phase and terminal placebo phase. After two weeks of single-blind placebo, patients were randomly assigned to one of two schedules of medication:...
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US Clinical Trial NCT00000325 – NIH – Sep 20, 1999

Psychostimulant Abuse - Novel Treatment Approaches

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US Clinical Trial NCT00000334 – NIH – Sep 20, 1999

Pharmacological Comparison of Buprenorphine and Methadone

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US Clinical Trial NCT00000337 – NIH – Sep 20, 1999

Infusion Laboratory: Protocol 1 - Selegeline

To develop a medication for the treatment of cocaine addiction using a medical human physio-neuro-psycho-immunology laboratory setting. To characterize this cocaine abusing population on a variety of psychological and physicologically measures over...
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US Clinical Trial NCT00000338 – NIH – Sep 20, 1999

Infusion Laboratory: Protocol 2 (Lisuride)

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US Clinical Trial NCT00000341 – NIH – Sep 20, 1999

Pharmacokinetics and Bioavailability of Liquid vs Tablet Buprenorphine

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US Clinical Trial NCT00000347 – NIH – Sep 20, 1999

Risperidone for Treatment of Cocaine Dependence in Outpatients

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US Clinical Trial NCT00000351 – NIH – Sep 20, 1999

Cognitive Correlates of Substance Abuse, Part 2

Part II: Examine cognitive performance of stimulant abusers (methamphetamine and cocaine) during recovery by assessing their cognitive function at monthly intervals.
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US Clinical Trial NCT00000353 – NIH – Sep 20, 1999

Efficacy/Safety Trial of Buprenorphine/Nx for Opiate Dependence

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US Clinical Trial NCT00000357 – NIH – Sep 20, 1999

Buprenorphine Maintenance for Opiate Dependence

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US Clinical Trial NCT00000358 – NIH – Sep 20, 1999

Safety Evaluation of Lofexidine for Treatment of Opioid Withdrawal

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US Clinical Trial NCT00000187 – NIH – Sep 20, 1999

Ritanserin in Treatment of Cocaine Dependence

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US Clinical Trial NCT00000190 – NIH – Sep 20, 1999

Cocaine in Parotid Saliva, Blood and Urine

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US Clinical Trial NCT00000196 – NIH – Sep 20, 1999

Neurobiology of Opioid Dependence: 5

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US Clinical Trial NCT00000197 – NIH – Sep 20, 1999

Propranolol for Treatment of Cocaine Addiction

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US Clinical Trial NCT00000198 – NIH – Sep 20, 1999

Piracetam for Treatment of Cocaine Addiction

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US Clinical Trial NCT00000202 – NIH – Sep 20, 1999

Buprenorphine Maintenance for Opioid Addicts

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US Clinical Trial NCT00000203 – NIH – Sep 20, 1999

Buprenorphine Maintenance for Opioid Addicts

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US Clinical Trial NCT00000204 – NIH – Sep 20, 1999

Buprenorphine Maintenance for Opioid Addicts

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US Clinical Trial NCT00000205 – NIH – Sep 20, 1999

Buprenorphine Maintenance Protocol

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US Clinical Trial NCT00000207 – NIH – Sep 20, 1999

Multicenter Clinical Trial of Buprenorphine

12 different sites for a total of 736 subjects (60 at Pizarro, 70 at West LA Tx center, 15 in the 1 year extension)
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US Clinical Trial NCT00000209 – NIH – Sep 20, 1999

Buprenorphine Dosing Interval

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US Clinical Trial NCT00000210 – NIH – Sep 20, 1999

Treatment Efficacy for Drug Abuse and AIDS Prevention

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US Clinical Trial NCT00000212 – NIH – Sep 20, 1999

IV Cocaine Abuse: A Laboratory Model

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US Clinical Trial NCT00000213 – NIH – Sep 20, 1999

IV Cocaine Abuse: A Laboratory Model

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US Clinical Trial NCT00000220 – NIH – Sep 20, 1999

Gradual Vs. Rapid Buprenorphine Detoxification

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US Clinical Trial NCT00000223 – NIH – Sep 20, 1999

Alternate-Day Buprenorphine Administration. Phase IV

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US Clinical Trial NCT00000227 – NIH – Sep 20, 1999

Alternate-Day Buprenorphine Administration. Phase VIII

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