Searching for keyword:"Suicidal Ideation"

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US Clinical Trial NCT01652430 – NIH – Dec 9, 2011

Experiential Avoidance in Combat Veterans With and Without Posttraumatic Stress Disorder

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US Clinical Trial NCT02096432 – NIH – Mar 19, 2014

Suicide Prevention in Chinese Older Adults

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US Clinical Trial NCT03170934 – NIH – May 23, 2017

The Effectiveness of Psychotherapy Classes in Reducing Suicidal Ideation

Suicide is the ninth leading cause of death in Canada, and rates are exponentially higher among specific sub-populations of Canadians (Statistics Canada, 2015). Worldwide, approximately 800,000 individuals die by suicide each year (WHO, 2016). A num...
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US Clinical Trial NCT02039479 – NIH – Jan 16, 2014

Randomized, Placebo-controlled Multicenter Trial of Lithium Plus Treatment as Usual (TAU) for Acute Suicidal Ideation and Behavior in Patients With Suicidal Major Depressive Episode

The study will consist of 254 adult patients, hospitalized for a major depressive episode with suicidal ideation and/or behaviour who will be randomized to two groups of each 127 participants. All study participants will receive treatment as usual i...
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US Clinical Trial NCT01507181 – NIH – Jan 6, 2012

Investigating Rapid Anti-Suicidal Ideation Effects of Intravenous (IV) Ketamine in Hospitalized Patients

Depression is a debilitating disorder that affects 12-20% of population and is among the top five leading causes of burden of disease worldwide (Kruijshaar ME 2005). Suicide associated with depression and other psychiatric disorders is a pervasive p...
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US Clinical Trial NCT03209544 – NIH – Jul 4, 2017

A Randomized Controlled Trial on the Effectiveness of an Online Self-help Intervention for Suicidal Ideation

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US Clinical Trial NCT02188485 – NIH – Jul 2, 2014

Social Connections and Late Life Suicide

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US Clinical Trial NCT03982043 – NIH – Jun 7, 2019

Text2Connect, Component 2 of iCHART (Integrated Care to Help At-Risk Teens)

Text2Connect (T2C) aims to increase perceived susceptibility/severity of depression/suicidality and decrease stigma in at-risk adolescents and their parents. The investigators hypothesize that modification of patient beliefs leads to change talk, th...
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US Clinical Trial NCT02932241 – NIH – Oct 10, 2016

Computerized DBT Skills Training for Suicidal and Heavy Episodic Drinkers

It is well established that clinical research should focus on streamlining treatments in ways that maximizes their potency and ease of implementation. The application of technology has been increasingly utilized as an effective and acceptable way to...
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US Clinical Trial NCT02499406 – NIH – Jun 1, 2015

Dialectical Behavior Therapy Skills Group Pilot Evaluation

Uncontrolled pilot study to examine feasibility, acceptability, and preliminary efficacy of Dialectical Behavior Therapy skills group for Veterans with suicidal ideation and emotion dysregulation. Outcome measures will occur at pre-treatment, mid, e...
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US Clinical Trial NCT03626142 – NIH – Jul 6, 2018

Assessing the Effectiveness of Psychiatric Interventions on the Inpatient Unit

Once patients have been discharged from hospital they will be contacted weekly for 4 weeks, at 6 and 8 weeks after the intervention and then monthly until 6 months post-intervention in order to monitor their symptoms. Participants will have consente...
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US Clinical Trial NCT01887990 – NIH – Aug 7, 2012

Treatment of Suicidal Ideation With Intravenous Ketamine Infusion

This study is dedicated to achieving better treatments for suicidal thoughts. Specifically, we are studying the effect of a medication called ketamine to quickly treat suicidal thoughts and depression. Patients will be asked to participate in a rese...
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US Clinical Trial NCT02326883 – NIH – Dec 23, 2014

UH3 Pragmatic Trial of Population-based Programs to Prevent Suicide Attempt

Each week, a programmer will use Epic/Clarity data to identify adult outpatients who completed a PHQ depression questionnaire in the previous week and reported thoughts of death or self-harm "most of the days" or "nearly every day". This trial will...
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US Clinical Trial NCT03527459 – NIH – May 2, 2018

Implementing an Interpersonal Theory of Suicide Treatment Approach to Improve Outcomes in Suicidal Youth

The trial will be conducted in a program where half of the clients are enrolled into either the original program (SPARC A which has a general focus on negative cognitions) or SPARC B (which will overlap significantly with SPARC A but targets in some...
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US Clinical Trial NCT03949556 – NIH – May 13, 2019

Internet-based Programmes for the Prevention of Suicidal Ideation in Medical Students

The main objective will be assessing their respective effectiveness on suicidal ideation (at least one occurrence over a 12-month period after the end of the intervention), through a randomized controlled trial, in medical students and interns.
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US Clinical Trial NCT02825771 – NIH – Jul 3, 2016

Caring Contacts: A Strength-based, Suicide Prevention Trial in 4 Native Communities

High rates of suicide are endemic in American Indian and Alaska Native (AI/AN) young adults. A recent study found that rates for young AI/AN adults in the Northern Plains and in Alaska are more than 4 times higher than for Whites of the same age in...
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US Clinical Trial NCT01441258 – NIH – Sep 21, 2011

Adaptation of Dialectical Behavior Therapy Skills-Groups for Individuals With Suicidal Ideation and Depression

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US Clinical Trial NCT03395392 – NIH – Jan 4, 2018

NRX-101 for Treatment of Moderate Bipolar Depression and Suicidal Ideation The MBD Study

Background and Rationale: NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. Specifically, NRX-100 (ketamine HCl, 0.5 mg/kg IV over 40 minutes) has been shown to induce acute reductions...
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US Clinical Trial NCT03396601 – NIH – Jan 5, 2018

Administration of Intravenous NRX100 (Ketamine) vs Placebo Infusion for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Patients With Bipolar Depression

Background and Rationale: NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. Specifically, NRX-100 (ketamine HCl, 0.5 mg/kg IV over 40 minutes) has been shown to induce acute reductions...
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US Clinical Trial NCT01398891 – NIH – Jul 15, 2011

Development of a Positive Psychology Intervention to Reduce Suicide Risk

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US Clinical Trial NCT03265964 – NIH – Aug 25, 2017

Clinical and Imaging Biomarker Trial of Uridine for Veterans With Suicidal Ideation

Veteran suicides, attempts and suicidal ideation (SI) remain an urgent concern for the Veterans Health Administration (VHA). Research indicates that approximately half of veteran suicides take place within 1 month of the decedent's final VHA encount...
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US Clinical Trial NCT02130583 – NIH – May 1, 2014

Skills to Enhance Positive Affect in Suicidal Adolescents

The prevalence of suicidal behaviors in adolescents remains unacceptably high. Reviews of published randomized controlled trials (RCTs) for adolescent suicidality conclude that treatments to date have been minimally efficacious. The preponderance of...
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US Clinical Trial NCT02037503 – NIH – Jan 14, 2014

Effect of Oral Ketamine Treatment on Suicidal Ideation and Drug Resistant Major Depression, a Clinical and fMRI Study

Suicide is a leading cause of death worldwide. Current strategies rely mostly on prevention, as there is no pharmacotherapy that seems to benefit patients in the acute phase of suicidal ideation. Conventional medications exert a beneficial effect on...
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US Clinical Trial NCT03788694 – NIH – Dec 26, 2018

Pilot Study of Open Label, Intranasal Ketamine for Suicidal Ideation in Veterans

To address the significant need for effective treatment of suicidal ideation in Veterans, this trial is designed as an open label pilot study of intranasal ketamine in 15 people.
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US Clinical Trial NCT02685943 – NIH – Feb 8, 2016

"Collaborative Assessment and Management of Suicidality" (CAMS) in Comparison to "Treatment as Usual" (TAU) for Suicidal Patients: a Randomized Controlled Trial

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US Clinical Trial NCT02116400 – NIH – Apr 15, 2014

Neuropsychological Characterization of Patients With Bipolar Disorder and a History of Suicide Attempt

The secondary objectives of this study are: A. Evaluate other aspects of cognitive functioning (using the Tower of London, the Probabilistic Reversal-learning task, the Rey Complex Figure, the Reading the Mind in the Eyes test) in euthymic patients...
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US Clinical Trial NCT03502551 – NIH – Mar 1, 2018

ED Treatment of Suicidal Patients With Ketamine Infusion

Suicide has risen to the 2nd leading cause of death in Americans aged 10 to 34, and is the10th leading cause of death overall. Globally, the World Health Organization estimates one person dies of suicide every 40 seconds. Despite its lethality, no r...
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US Clinical Trial NCT03595254 – NIH – Jun 29, 2018

Thrive-Montana: A Computerized Cognitive Behavior Therapy (cCBT) Program to Reduce Depression, Anxiety, Suicidal Ideation and Behaviors for Rural Montanans

The efficacy of Thrive has been studied among patient and community populations and has shown to effectively reduce depression and anxiety symptoms among adults with moderate to severe depression symptoms at baseline. This study will examine whethe...
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US Clinical Trial NCT01700829 – NIH – Oct 2, 2012

Ketamine vs. Midazolam: Testing Rapid Relief of Suicide Risk in Depression

Patients currently taking psychiatric medications may continue them during the study. However, if a patient is taking a benzodiazepine (such as Ativan, Klonopin, or Xanax), they will be able to take up to 2mg per day of Lorazepam during the week bef...
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US Clinical Trial NCT01689909 – NIH – Sep 18, 2012

Reducing Suicidal Ideation Through Insomnia Treatment

Primary Aim: We will assess the effect of treating insomnia with hypnotic medication on the intensity of suicidal ideation in depressed outpatients with insomnia and suicidal ideation. -Hypothesis 1. Treatment of depressed, insomniac and suicidal o...
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US Clinical Trial NCT02299440 – NIH – Nov 20, 2014

Evaluation of the Effects of Ketamine in the Acute Phase of Suicidal Ideation: a Multicenter Randomized Double-blind Trial

The secondary objectives of this study are to assess: A. The maintenance of medium-term effectiveness of ketamine on the resolution of suicidal ideation B. The evolution of the full spectrum of suicidality under ketamine compared to placebo C. Th...
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US Clinical Trial NCT03677882 – NIH – Sep 10, 2018

A Randomized Pilot Study of a Brief Mind-Body Bridging Intervention for Suicidal Ideation

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US Clinical Trial NCT02532153 – NIH – Aug 21, 2015

The Impact of Ketamine on the Reward Circuitry of Suicidal Patients: An MRI Study

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US Clinical Trial NCT00863291 – NIH – Mar 15, 2009

Phase 3 Study of the Effects of Buprenophine as Add-on Treatment to Antidepressants in Treating Acutely Suicidal Depressed Inpatients

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US Clinical Trial NCT03402152 – NIH – Jan 4, 2018

Validation of the Glx Biomarker for Treatment of Moderate Bipolar Depression With NRX-101

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US Clinical Trial NCT03221530 – NIH – Jul 16, 2017

Early Intervention for Suicide Risk Among Immigrant Youth

Suicide is the second-leading cause of death among adolescents, with rates increasing between 1999 and 2014. Family-based preventive interventions demonstrate promise for reducing suicide risk among adolescents, and are particularly relevant for add...
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US Clinical Trial NCT02986113 – NIH – Dec 2, 2016

Men and Providers Preventing Suicide (MAPS): A Randomized Controlled Trial

In this study, the investigators will enroll middle-aged men with active suicide thoughts in a randomized controlled trial (RCT) to examine whether their use of the Men and Providers Preventing Suicide (MAPS) tailored interactive multimedia patient...
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US Clinical Trial NCT02176824 – NIH – Jun 24, 2014

Adjunct Total Sleep Deprivation, Sleep Phase Advance, and White Light Therapy Vs. Partial Sleep Deprivation, Sleep Phase Delay, and Amber Light Therapy as Adjunctive Treatments in Acutely Suicidal and Depressed Inpatients.

There is a consistently reported, rapid antidepressant response to a single night of total sleep deprivation in both unipolar, and bipolar depression. The clinical utility of this technique has been limited however, because responders have typically...
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US Clinical Trial NCT00951821 – NIH – Aug 3, 2009

Concurrent Treatment for Parents and Adolescents Who Attempt Suicide

Depression, like many psychiatric disorders, has a genetic component that makes it more likely that members of the same family will have the disorder. Depression in parents, particularly mothers, may put the children at greater risk for depression....
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US Clinical Trial NCT01770587 – NIH – Jan 14, 2013

A Sleep-Oriented Intervention for Suicidal Behaviors

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US Clinical Trial NCT02664701 – NIH – Jan 19, 2016

Cognitive Behavioural Group Therapy Versus Individual Supportive Therapy for the Prevention of Repeat Suicide Attempts: a Multicentre, Assessor-blinded, 2-parallel-group, Randomised, Superiority Trial

The secondary objectives of this study are to assess the efficacy of CBGT on: A. parameters describing the incidence of suicide and repeat suicide attempts, as well as suicide re-attempt free follow-up time, B. long-term changes in suicidal ideati...
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US Clinical Trial NCT00575575 – NIH – Dec 15, 2007

the Research on Suicidal Ideation of University Students in Harbin City and Intervention on Them

By using suicidal ideation scale, to assess the status of suicidal ideation and suicidal attempt in 6000 university students in Harbin city. About 300 students with suicidal ideation and depression disorder randomized into two groups (control and in...
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US Clinical Trial NCT01924936 – NIH – Jul 17, 2013

Pilot Study of Online Interventions for Population-based Suicide

Reducing the risk of suicide attempt and suicide is a public health priority. There has been no substantial decrease in suicide for the past two decades. Prevention efforts to date have focused on primary (e.g. public service announcements) and tert...
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US Clinical Trial NCT03396068 – NIH – Nov 2, 2017

NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Acute Suicidal Ideation and Behavior: The SBD-ASIB Study

NeuroRx is developing NRX-101, a fixed-dose combination oral capsule composed of D-cycloserine (DCS) and lurasidone for the maintenance of remission from Severe Bipolar Depression with Acute Suicidal Ideation or Behavior (ASIB) in adults with Bipola...
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US Clinical Trial NCT02693743 – NIH – Feb 12, 2016

Repetitive Transcranial Magnetic Stimulation as Treatment for Acute Suicidality in Adult Patients

The proposed study seeks to improve the prevention of suicide by advancing our understanding of the neurobiology of suicide by using a randomized control trial of repetitive transcranial magnetic stimulation (rTMS) as a hypothesis driven interventio...
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US Clinical Trial NCT02227160 – NIH – Aug 26, 2014

Group Interventions for Suicidal African Americans

Attention will be paid to Theory of Triadic Influence intrapersonal, social/ situational, and cultural/ environmental risk and protective factors that impact outcomes. The central hypothesis is that compared to enhanced treatment as usual, through t...
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US Clinical Trial NCT02021344 – NIH – Dec 14, 2013

Mental Health First Aid for College Students: A Multi-campus Randomized Control Trial of a Community Health Intervention

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US Clinical Trial NCT03121742 – NIH – Apr 6, 2017

A Pilot Study of a Smartphone-based Intervention for Suicidal Inpatients

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US Clinical Trial NCT03539887 – NIH – May 16, 2018

A Randomized, Double-Blind, Placebo-Controlled Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse

Clinicians have a limited ability to predict imminent suicidal behavior and efficacious treatments are not available to treat suicidal patients. Thus, Rapid-acting treatments for suicidal individuals are truly needed. This project aims to evaluate t...
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US Clinical Trial NCT01599247 – NIH – May 2, 2012

Natural History of Hopelessness, Suicidality, and Optimism in Psychiatric Inpatients Following Discharge

Contact information. On the day of enrollment, contact information (address, phone number) will be obtained from the subject. Subjects will also be asked to provide the contact information for a family member or friend who the study team may contact...
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