Searching for keyword:"Sleep Deprivation"

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US Clinical Trial NCT02496962 – NIH – Jul 5, 2015

Protective Effect of Statin on Arrhythmia and Heart Rate Variability in Healthy People With 48 Hours of Sleep Deprivation

In the setting of earthquakes, floods, or fire disasters, rescue workers usually carry out their work without sleep. Sleep deprivation (SD), which is a strong stressor, can exert a large effect on the cardiovascular system of rescue workers. It has...
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US Clinical Trial NCT00849706 – NIH – Feb 19, 2009

Effect of Work Load and Sleep Deprivation on Medical Staff's Driving Skills

Medical staff in Israel has long and unorthodox working hours. During residency, doctors stay overnight for shifts after working the normal working hours for a total of 24h, without regular set breaks or certainty of even one hour of sleep. Nurses,...
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US Clinical Trial NCT01334788 – NIH – Oct 26, 2010

Sleep Deprivation and Energy Balance

The demands of present day living have placed a high premium on time. Voluntary sleep curtailment is endemic and many adults typically sleep an average of six hours per night. Observational data suggest that short sleep duration is associated with a...
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US Clinical Trial NCT01433315 – NIH – Aug 15, 2011

Physiologic Effects of Sleep Restriction

Evidence suggests a relationship between sleep deprivation and cardiovascular disease. Voluntary sleep restriction is common, with 28% of the US adult population reports getting 6 or fewer hours of sleep per night, and those who do are 24% more like...
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US Clinical Trial NCT03957317 – NIH – May 17, 2019

Improving Sleep Quality and Satisfaction for Postoperative Plastic Surgery Flap Patients in the CUH SICU

Patients will be identified during their presurgical clinic visit or anesthesia preoperative clinic visit for eligibility. The electronic medical record (Epic) will also be used for prescreening of potential study participants by reviewing the clini...
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US Clinical Trial NCT01096680 – NIH – Mar 30, 2010

A Phase 2, Randomized, Double-Blind, Single Center, Parallel Group, Placebo and Active Comparator, Controlled Study to Evaluate the Pharmacodynamic Profile of Single Doses of SPD489 in Healthy Adult Male Subjects Undergoing a Nocturnal Period of Acute Sleep Loss

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US Clinical Trial NCT03981770 – NIH – Jun 7, 2019

Characterisation of Gut Microbiota, Bispectral Index Data and Plasma Kynurenine in Patients Undergoing Thyroid Surgery

The study is a case-controlled observational trial. Forty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data. Firstly, this study aims to characterise the lung microbiota...
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US Clinical Trial NCT01651429 – NIH – Jul 23, 2012

Multimodal Neuroimaging to Predict Cognitive Resilience Against Sleep Loss

Resilience, the ability to cope effectively and adapt to a wide range of stressful environmental challenges, appears to be mediated extensively by the medial prefrontal cortex (MPFC). Sleep deprivation has been shown to reduce metabolic activity thr...
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US Clinical Trial NCT02824770 – NIH – Jun 28, 2016

Effects of Sleep Quality on Melatonin Levels and Inflammatory Response After Major Abdominal Surgery in an Intensive Care Unit

This study is going to be conducted in accordance with the Helsinki Declaration and has been approved by Eskisehir Osmangazi University Ethics Committee. Forty consecutive patients, aged 18-65, who will undergo elective major abdominal operations wi...
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US Clinical Trial NCT03692650 – NIH – Sep 20, 2018

Influence of Cognition and Physiological Function by Partial Sleep Deprivation of Taiwan University Students During Final Exam

40 healthy young university students who meet the inclusion criteria will be enrolled to the study. The investigators will detailed explain the research process to participants, and make sure all participants provide written informed consent. The st...
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US Clinical Trial NCT03755011 – NIH – Nov 26, 2018

White Noise to Improve Sleep in the MICU: a Pilot and Feasibility Study

The ICU is full of alarms and critically ill patients, so it is no surprise that sleep is very much fragmented and poor in this setting, as documented in numerous studies. White noise is a simple intervention that has been shown to improve sleep, in...
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US Clinical Trial NCT02697266 – NIH – Dec 21, 2015

Individual Coping Strategies After Night Calls: Effects on Performing Clinical and Cognitive Tasks

This is a prospective study evaluating the reaction time among attending anesthesiologists, and anesthesiology residents who take night shift call and are suffering from sleep deprivation. Investigators plan to examine clinical performance by measur...
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US Clinical Trial NCT02755493 – NIH – Apr 18, 2016

Quantifying and Developing Countermeasures for the Effect of Fatigue-Related Stressors on Automation Use and Trust During Robotic Supervisory Control"

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US Clinical Trial NCT01284842 – NIH – Jan 26, 2011

Call-associated Acute Fatigue in Surgical Residency- Subjective Perception or Objective Fact?

Summary Background Data: The effect of acute partial sleep deprivation on surgical proficiency is still controversially discussed. The present study is the first to measure objective physiological parameters of fatigue in respect to subjective perc...
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US Clinical Trial NCT00800553 – NIH – Dec 1, 2008

The Neural and Behavioral Correlates of How Donepezil Modulates Memory and Inhibitory Efficiency in the Context of 24 Hours of Sleep Deprivation

Short-term total sleep deprivation (SD) can result in cognitive impairments (Durmer and Dinges, 2005) that contribute to industrial catastrophes, transportation accidents, and medical errors (Mitler et al., 1988; Dinges, 1995; Barger et al., 2006; P...
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US Clinical Trial NCT03182413 – NIH – Jun 6, 2017

Therapeutic Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep Deprivation in Healthy Subjects

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US Clinical Trial NCT03614572 – NIH – Jul 21, 2018

Advancing Adolescent Bedtime by Using Motivational Interviewing and Text Reminders - A Randomized Controlled Trial

This study will conduct a randomized control trial to evaluate the effectiveness of group-based sleep intervention using motivational interviewing plus text reminders in changing adolescent sleep deprivation problem with both subjective and objectiv...
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US Clinical Trial NCT01823263 – NIH – Feb 21, 2013

Metabolic and Cognitive Effects of Sleep Deprivation

It is predicted that partial sleep deprivation negatively affects the hormonal status, e.g. upregulating ghrelin and other hunger-promoting hunger hormones, while showing impaired memory functions. It is also predicted that participants will tend to...
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US Clinical Trial NCT03313115 – NIH – Oct 11, 2017

Sleep/Wake Protocol Implementation to Improve Sleep Quality and Reduce Delirium in a Surgical and Cardiovascular Intensive Care Unit

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US Clinical Trial NCT01057823 – NIH – Jan 26, 2010

Environment and Perceived Control: Improving Sleep in Hospitalized Older Patients

This research can lead to a better understanding of the effects of inpatient sleep on health outcomes for hospitalized older patients and can help inform the design and evaluation of interventions designed to improve sleep in hospitalized older pati...
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US Clinical Trial NCT01684085 – NIH – Sep 5, 2012

Explanation About Sleep Given After Traumatic Event, and Its Effect on the Trajectory of Post Traumatic Stress Disorder (PTSD)

This is a Single blind, prospective, placebo controlled trial in which trauma victims are randomized to receive an explanation about the first sleep following trauma exposure. To provide a baseline prior the explanation, participants will receive a...
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US Clinical Trial NCT00669513 – NIH – Apr 28, 2008

Cardiovascular Effects of Partial Sleep Deprivation in Healthy Volunteers

Volunteers Healthy young male volunteers from the urban area of Sao Paulo city will be recruited to the study. All subjects will be clinically evaluated, including measurements of weight and height. Exclusion criteria include age less than 21 and mo...
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US Clinical Trial NCT00643136 – NIH – Mar 19, 2008

Pregabalin BID Add-on Trial: a Randomized, Double-Blind, Placebo-Controlled Parallel-Group Single-Center Sleep EEG Study in Patients With Partial Seizures and Sleep Disturbance Part B: a Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study of Pregabalin Add-on Treatment

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US Clinical Trial NCT01800253 – NIH – Feb 21, 2013

The Role of Acute Total Sleep Deprivation in the Regulation of Metabolism, Neuroendocrine Responses, and Behavioral Measures

It is predicted that acute total sleep deprivation will affect gene expression and DNA methylation. It is also predicted that sleep deprivation will up-regulate ghrelin, and affect other neuroendocrine markers and hormones in a negative manner. It i...
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US Clinical Trial NCT02945501 – NIH – Oct 21, 2016

Transcranial Electrical Stimulation at Slow Oscillation Frequency During NREM Sleep: An Assessment of Effects on the Restorative Properties of Sleep

40 subjects will be enrolled and randomized to participate in this study. A 60 minute TES stimulation sequence consisting of a SO frequency stimulation (TES SO) using the NeuroConn DC Stimulator PLUS or a sham stimulation will be administered during...
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US Clinical Trial NCT03926221 – NIH – Apr 4, 2019

Parent-Adolescent Interpersonal Processes in the Science of Behavior Change

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US Clinical Trial NCT02665247 – NIH – Jan 22, 2016

Impact of Sleep Workshops in College Students

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US Clinical Trial NCT00874510 – NIH – Mar 31, 2009

Interventions to Improve Fatigue Management Among Physician Trainees

Background: The release of the Institute of Medicine report on resident work hours and patient safety highlighted the risks to patient and resident safety of extended duty on-call shifts. Objectives: The purpose of this study is to test the feasibi...
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US Clinical Trial NCT01623674 – NIH – Jun 18, 2012

Laparoscopic Skills and Cognitive Function Are Not Affected by Night Shifts in Surgeons

The surgeons wore an actigraph consecutively on all 4 days, and would fill out a sleep diary on all 4 days as well. The surgeons were heart monitored consecutively on day 1 and 2. The surgeons were tested in a laparoscopic simulator at 8 a.m. day 1...
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US Clinical Trial NCT01794689 – NIH – Feb 15, 2013

Mechanisms of Sleep Disruption Hyperalgesia

This research is being conducted in order to evaluate the effects of disrupted sleep patterns on mood, inflammation, the perception of pain, and pain relief. This study will help researchers understand the relationship between sleep and pain, and ho...
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US Clinical Trial NCT03213860 – NIH – Jul 2, 2017

The Effect of Night Eye Mask on Post-operative Pain in Cardiac Surgery Patients

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US Clinical Trial NCT02484846 – NIH – Jun 24, 2015

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US Clinical Trial NCT01730742 – NIH – Oct 11, 2012

The Role of Sleep Deprivation in the Regulation of Immune System, Neuroendocrine Responses, and Behavioral Measures.

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US Clinical Trial NCT03322371 – NIH – Oct 23, 2017

Validation of Frontal Limited Lead Electroencephalography (EEG) to Formal Polysomnography (PSG) in the Intensive Care Unit (ICU)

Sleep in the intensive care unit (ICU) is poor and not well understood. Formal polysomnography (PSG) is the gold standard measure, but impractical for critical care. The relative influence of environment, illness and interventions on sleep in critic...
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US Clinical Trial NCT02691013 – NIH – Dec 28, 2015

The Impact of Ramelteon on Sleep and Delirium in Patients Who Undergo Pulmonary Thromboendarterectomy (PTE) Surgery

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US Clinical Trial NCT00560456 – NIH – Nov 16, 2007

Chronic Sleep Restriction and Driving in Healthy Subjects or Snorers : Interindividual Vulnerability and Recovery Factors

Principal objective : To determine whether chronic sleep restriction affects more snorers driving performances than healthy subjects' driving performances. To determine whether chronic sleep restriction affects more young people driving performanc...
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US Clinical Trial NCT02082600 – NIH – Mar 6, 2014

Effects of Sleep Deprivation on Blood Hormones and Inflammatory Status After Exercise Induced-muscle Damage

The blood parameters analyzed will be: - Creatine kinase and myoglobin: before, immediately after, 2, 4, 12, 24, 36, 48, and 60 hours after exercise protocol. - Total and free testosterone, IGF-1, and cortisol: before, immediately after, 2, 4, 12,...
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US Clinical Trial NCT02117193 – NIH – Apr 14, 2014

Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Cardiorrespiratory, Neuromuscular and Hormonal Responses in Healthy Males.

Ten subjects were randomized in four situations after familiarization and control situation: (1) alcohol intake combined with sleep normal; (2) alcohol intake combined with sleep deprivation; (3) placebo intake combined with sleep normal and (4) pla...
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US Clinical Trial NCT02125656 – NIH – Apr 25, 2014

Use of High Intensity Interval Training as a Strategy to Minimize the Insulin Resistance Observed in Sleep Deprivation

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US Clinical Trial NCT00494468 – NIH – Jun 28, 2007

Single Dose Pharmacokinetic and Pharmacodynamic Evaluation of Three Different Zolpidem Doses in Children Ages 2 to 18 Years of Age

The consequences of sleep deprivation to the productivity of the individual and society are extensive. (Most clinicians and patients believe that insomnia becomes a clinical problem requiring therapy when excessive daytime sleepiness impairs cogniti...
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US Clinical Trial NCT01930279 – NIH – Aug 25, 2013

Effect of Sleep Deprivation on Expression of T Cell Markers in Peripheral Blood of Medical Residents

Overall Study Design and Plan 1. Subjects will be bled on the day of the experiment between 8and 9 AM. 2. Blood tubes will be tested for T cell markers, serum cytokines levels, and other immune parameters by western blots. 3. The first tube will...
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US Clinical Trial NCT02305225 – NIH – Nov 7, 2014

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US Clinical Trial NCT03767426 – NIH – Dec 5, 2018

The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity

Goal 1: How does sleep deprivation impact emotion perception and memory processing? The investigators are interested in how an acute loss of sleep impairs our ability to properly perceive, consolidate, and retrieve emotional information. There has b...
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US Clinical Trial NCT03784560 – NIH – Dec 16, 2018

Effects of Partial Sleep Deprivation on Cognitive Function of Anesthesiologists Following Night Shift; Observational Study.

Anesthesiology is one of the few health-care professions that often demands split-second decisions. This is especially true in a trauma setting where the situation in the operating room can change drastically in a few seconds. Anesthesiologists who...
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US Clinical Trial NCT00261898 – NIH – Dec 4, 2005

Chronic Sleep Deprivation as a Risk Factor for Metabolic Syndrome and Obesity

OBJECTIVE: Obesity and chronic sleep deprivation have both become increasingly pervasive medical problems in recent years. The prevalence of adult obesity has doubled over the past 30 years and continues to increase. In addition, industrial societie...
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US Clinical Trial NCT00506428 – NIH – Apr 27, 2007

Sleep, Aging, and Circadian Rhythm Disorders

It has long been recognized that sleep patterns change with age. A common feature of aging is the advance of the timing of sleep to earlier hours, often earlier than desired. Polysomnographically-recorded sleep in older people shows an increased num...
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US Clinical Trial NCT02130791 – NIH – Apr 29, 2014

Phenotypic and Genotypic Markers of Performance Vulnerability to Sleep Loss

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US Clinical Trial NCT01603550 – NIH – May 18, 2012

Brain Energy and Cognition

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US Clinical Trial NCT03640416 – NIH – Aug 15, 2018

The Feasibility to Use Wearable Devices to Collect Physiologic Data During Night Shifts - A Pilot Study

Background There is an increase interest in the use of wearable activity trackers and wearable technology in the various medical fields. Such devices can increase physical activity and decrease weight significantly. Shift work is usually referred t...
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US Clinical Trial NCT01461174 – NIH – Oct 17, 2011

Effects of 15-day Donepezil and Memantine on Cognitive Functions After a 24 Hours Sleep Deprivation Challenge in Healthy Volunteers: a Double-blind, Placebo-controlled, Randomised, Cross-over Study, With Modafinil as Positive Control

BACKGROUND: With the inherent difficulty of detecting significant improvements in cognitive performance in normal healthy subjects, it is presently incredibly hard to predict and select efficacious agents early in the drug development process. As s...
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