Searching for keyword:"Neurodegenerative Diseases"

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US Clinical Trial NCT03938909 – NIH – Apr 16, 2019

Ccf mtDNA as a Biomarker in Neurological and Neurodegenerative Diseases

To date, the specific causes of multiple sclerosis (MS) remain uncertain, and in its pathogenesis an interaction between environmental and genetic factors has been implicated leading to inflammation, demyelination and neurodegeneration of the centra...
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US Clinical Trial NCT03299062 – NIH – Sep 27, 2017

Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders

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US Clinical Trial NCT00340301 – NIH – Jun 19, 2006

Exposure to Neurotoxins as Risk Factors for ALS: Measurement of Genes, Proteins, Neurotoxicants, and Other Factors Potentially Associated With ALS

OBJECTIVES: Stored blood and toenail samples are available from a case-control study of ALS conducted in 1993-1996. The purpose of the initial study was to examine the relationship to ALS of lead and other exposures, including mercury, pesticides, a...
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US Clinical Trial NCT02222779 – NIH – Aug 20, 2014

Quantification of Transition Metals in Patients at the Cologne University Hospital

Samples used include: Remaining portions of samples collected for diagnostic or therapeutic reasons (paired CSF and blood serum samples). No lumbar puncture will be done specifically for this protocol. The objective of this study is to gain an ove...
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US Clinical Trial NCT00316797 – NIH – Apr 19, 2006

Phase 1 Assessment of the Biodistribution and Safety of 123-I INER in Healthy Subjects

All subjects will receive a full physical examination at IND to determine study eligibility. Written informed consent will be obtained prior to any study procedures. The screening procedures will include: review of medical and psychiatric history, r...
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US Clinical Trial NCT02267434 – NIH – Sep 4, 2014

A Randomized, Placebo-controlled, Parallel Group, Patient-blinded, Multi-center, Phase I Pilot Study to Assess Tolerability and Safety of Two Doses of AFFITOPE® PD03A Formulated With Adjuvant to Patients With Early Parkinson's Disease

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US Clinical Trial NCT01384825 – NIH – Jun 27, 2011

Observational Study of the Prevalence of CCSVI in Multiple Sclerosis and in Other Neurodegenerative Diseases

It has been recently reported the possible presence of abnormalities in the cerebral venous circulation of people with MS, in healthy controls and in people with other neurological diseases. These reports have aroused much interest both in the scien...
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US Clinical Trial NCT03682458 – NIH – Sep 17, 2018

Study of Neurological Pathological Mechanisms of and Neurodegenerative Diseases in Neurons and Glia Derived From Induced Stem Cells (iPS) in Patients and Healthy Family Controls.

1. INTRODUCTION Neurological and neurodegenerative diseases have a major impact in families and in the national health service due to the lack in many cases of effective and long-lasting therapies. The lack of these therapeutic strategies is due in...
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US Clinical Trial NCT03336489 – NIH – Nov 5, 2017

Evaluation of the Organization of Continuity of Care for Home Hospice Patients by Four Parisian Health Networks

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US Clinical Trial NCT03621839 – NIH – Jul 25, 2018

New Diagnosis or Prognosis Biomarkers for Alzheimer's Disease: Biobank of CSF Collected as Part of Differential Diagnosis of Dementia

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US Clinical Trial NCT02270489 – NIH – Sep 4, 2014

A Randomized, Placebo-controlled, Parallel Group, Patient-blind, Phase I Study Assessing the Safety and Exploring the Immunogenicity/Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early Multiple System Atrophy

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US Clinical Trial NCT02470325 – NIH – Jun 4, 2015

A Randomized Double Blind Study of Cannabis on Dystonia and Spasticity in Pediatric Patients

The purpose of this study is to examine the effect of two cannabis oils containing the main cannabinoid Δ9 -THC and CBD ratio of 1 to 6 and 1 to 20 (respectively), on spastic movement disorder and dystonia. 40 children will be enrolled in this stud...
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US Clinical Trial NCT01954875 – NIH – Mar 30, 2013

Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases

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US Clinical Trial NCT02275884 – NIH – Oct 17, 2014

Evaluation of Plasma Concentrations of Pharmacologically Active Constituents of Chocolate and Their Symptomatic Effects in Patients With Idiopathic Parkinson's Disease

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US Clinical Trial NCT01558479 – NIH – Mar 16, 2012

The Parkinson's Genetic Research Study (PaGeR)

PaGeR is focusing on families in which two or more people have been diagnosed with PD. Past research suggests that such "multiplex" families might hold the key to the discovery of new PD genes. To take part in PaGeR, participants will be asked to c...
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US Clinical Trial NCT01920100 – NIH – Aug 5, 2013

Resource Use and Disease Course in Dementia (REDIC)

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US Clinical Trial NCT03426488 – NIH – Dec 18, 2017

Northern Sweden Health and Disease Study

The overall aim of the NSHDS is to support frontline research with particular emphasis on improving diagnostic tools for clinical use, as well as finding early markers of disease, using the blood samples, tissue and associated health data from the N...
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US Clinical Trial NCT02211287 – NIH – Aug 6, 2014

Promoting Informed Decision Making and Effective Communication Through Advance Care Planning for People With Dementia and Their Family Carers

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US Clinical Trial NCT01291550 – NIH – Feb 7, 2011

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US Clinical Trial NCT01051128 – NIH – Jan 15, 2010

Continuous Intrathecal Baclofen Infusion for the Management of Chronic Spasticity

The Prometra Programmable Pump is a battery-operated, implantable, programmable infusion pump that dispenses drug solution into the intrathecal space through an implanted infusion catheter. All functions of the system (e.g., dosing) are controlled e...
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US Clinical Trial NCT00956410 – NIH – Aug 10, 2009

An Open-label Extension to a 52-week, Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel Group Study in Patients With Alzheimer's Disease to Investigate the Safety and Tolerability of Repeated Subcutaneous Injections of CAD106

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US Clinical Trial NCT01689233 – NIH – Sep 14, 2012

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 18-Month Safety and Efficacy Study of TRx0237 in Subjects With Mild Alzheimer's Disease

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US Clinical Trial NCT02874911 – NIH – Aug 12, 2016

Coordination Training With Complete Body Video Games in Children and Adults With Degenerative Ataxias

Effective treatments for patients with degenerative spinocerebellar ataxia are scarce. It has recently been shown that intensive coordinative training based on either physiotherapy or exergames (= whole-body controlled videogames; might improve dege...
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US Clinical Trial NCT03816020 – NIH – Dec 7, 2018

NAD-PARK: A Double-blinded Randomized Pilot Trial of NAD-supplementation in Drug naïve Parkinson's Disease

Individuals with PD (n=30) will be recruited starting 14/02/2019 from the department of Neurology, Haukeland University Hospital. Only newly diagnosed and drug naïve PD patients are eligible for inclusion. After initial assessment at baseline, the p...
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US Clinical Trial NCT00537017 – NIH – Sep 27, 2007

A Phase 2, 36-Week, Open-Label, Uncontrolled Safety Follow-up Study Assessing SCH 420814 (Preladenant) 5 mg BID (P05175)

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US Clinical Trial NCT00999388 – NIH – Oct 20, 2009

Shanghai Parkinson's Study

We propose to clinically examine self-reported Parkinson s disease (PD) patients from the well established Shanghai Women s Health Study (SWHS) and thus initiate a long-term PD research in this unique Chinese women cohort. The SWHS cohort was establ...
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US Clinical Trial NCT00714220 – NIH – Jul 10, 2008

Quantitative Measurement of Nutritional Substrate Utilization in Patients With ALS

Study groups will include ALS patients with and without respiratory failure as judged by their FVC and use of either noninvasive or invasive ventilation along with normal controls. For all patients, nutritional status will be assessed by measurement...
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US Clinical Trial NCT00795418 – NIH – Nov 10, 2008

A 52-week,Multi-center,Randomized,Double-blind,Placebo-controlled,Parallel Group Study in Patients With Mild Alzheimer's Disease to Investigate the Safety and Tolerability of Repeated Subcutaneous Injections of CAD106

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US Clinical Trial NCT03242109 – NIH – Jul 31, 2017

An Epidemiological Study of Risk Factors for Cardiovascular Disease and Tumors in an Adult Population of the Molise Region

The cohort of the Moli-sani study has recruited 24,325 persons, aged >35 years, resident in the Molise region.The latter covers an area of 4,438 Km2, including 136 towns. Participants are recruited from city-hall registries by a multistage sampli...
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US Clinical Trial NCT03061474 – NIH – Feb 13, 2017

A Double-Blind-Randomized, Placebo-Controlled Adaptive Design Trial of Nicotinamide in Mild Cognitive Impairment Due to Alzheimer's Disease and Mild Alzheimer's Disease Dementia

Nicotinamide, the amide of nicotinic acid (vitamin B3/niacin), is an oral therapy with a wealth of clinical data in a variety of therapeutic areas, including preliminary data supporting its safety in Alzheimer's disease (AD). Preclinical work in a m...
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US Clinical Trial NCT01097096 – NIH – Mar 29, 2010

A 90-week, Multi-center, Randomized, Double-blind, Placebo-controlled Study in Patients With Mild Alzheimer's Disease (AD) to Investigate the Safety, Tolerability and Abeta-specific Antibody Response Following Repeated i.m. Injections of Adjuvanted CAD106

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US Clinical Trial NCT00367900 – NIH – Aug 22, 2006

The Parkinson's, Genes and Environment (PAGE) Study

Parkinson s disease (PD) is the second most prevalent neurodegenerative disease, affecting more than 1 million elderly Americans. The causes of PD are largely unknown, but may include both genetic and environmental factors. We thus propose a large s...
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US Clinical Trial NCT00733863 – NIH – Aug 8, 2008

A 52-week,Multi-center,Randomized,Double-blind,Placebo-controlled,Parallel Group Study in Patients With Mild Alzheimer's Disease to Investigate the Safety and Tolerability of Repeated Subcutaneous Injections of CAD106

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US Clinical Trial NCT01577394 – NIH – Feb 23, 2012

Oculomotor Recording in the Contribution to the Early Differential Diagnosis of Dementia With Lewy Bodies and Alzheimer's Disease

Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia. In its early stages, the differential diagnosis of DLB and Alzheimer's disease (AD) can be challenging. The differential diagnosis is particularly importa...
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US Clinical Trial NCT01689246 – NIH – Sep 14, 2012

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 15-Month Trial of TRx0237 in Subjects With Mild to Moderate Alzheimer's Disease

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US Clinical Trial NCT02656498 – NIH – Jan 12, 2016

An Open Label, Multicenter Study for Evaluation of the Clinical Utility of [18F]THK-5351 Positron Emission Computed Tomography in Cognitively Healthy Volunteers, Subjects With Mild Cognitive Impairment, Subjects With Alzheimer's Disease and Subjects With Other Neurodegenerative Diseases

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US Clinical Trial NCT03353207 – NIH – Nov 21, 2017

Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for Precursor Biomarker for Neurodegeneration

In the past two decades, a number of studies have confirmed that most patients with idiopathic RBD will eventually develop neurodegenerative diseases, especially α-synucleinopathies. Previous studies, including our preliminary data, suggested that R...
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US Clinical Trial NCT02867969 – NIH – Aug 11, 2016

Slowing Down Disease Progression in Premanifest SCA: a Piloting Interventional Exergame Trial

In many neurodegenerative diseases, including spinocerebellar ataxias (SCA), large populations of neurons are already lost and compensatory resources exhausted at time of clinical diagnosis. This calls for early intervention strategies aiming to slo...
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US Clinical Trial NCT03153540 – NIH – Mar 1, 2017

A Randomized, Double-blinded, Sham-controlled Cross-over Study of Theta-burst Transcranial Magnetic Stimulation in Nonfluent/Agrammatic Variant Primary Progressive Aphasia

This study is a randomized controlled blinded cross-over treatment trial that involves 20 iTBS treatment sessions (10 active treatment sessions; 10 sham treatment sessions) and the study will last between 6 weeks. There will be 20 treatment visits (...
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US Clinical Trial NCT03289143 – NIH – Sep 18, 2017

A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study of MTAU9937A in Patients With Prodromal to Mild Alzheimer's Disease

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US Clinical Trial NCT01450891 – NIH – Sep 20, 2011

Novel Diagnostic Approaches for the Diagnosis of Alzheimer's Disease: Technology Assessment and Clinical Effectiveness

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US Clinical Trial NCT02414230 – NIH – Apr 7, 2015

F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis (IND 123119 Protocol B)

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US Clinical Trial NCT02129452 – NIH – Apr 28, 2014

Research of Olfactory Neuroepithelial Tissue as a Potential Biomarker of Alzheimer Disease

Alzheimer disease is the most common form of dementia characterized by insidious onset and slow progression. Pathological changes in the brain of Alzheimer disease (AD) precede clinical symptoms many years, and early treatment provide better outcome...
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US Clinical Trial NCT03813862 – NIH – Jan 11, 2019

OPERA Longitudinal Observational Database in the Study of Chronic Diseases, Treatments and Outcomes

Objectives of OPERA 1. To research numerous chronic diseases (HIV, HCV, HBV currently and IBD and RA in the near future, with others as identified for further consideration) utilizing the OPERA® longitudinal database that consists of de‐identified...
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US Clinical Trial NCT03858283 – NIH – Feb 26, 2019

Mindfulness Based Health Care (MBHC) Program for Caregivers in the Neuropsychiatric Disorders in Alzheimer Patients and Anxiety and Depression in Caregivers

Alzheimer's disease is a progressive brain disorder that involves the loss of the ability to live independently, functional capacity and safety. Thus, patients often suffer neuropsychiatric disorders and need help from another person to live every d...
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US Clinical Trial NCT01023685 – NIH – Dec 1, 2009

An Open-label Extension to a 52-week, Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel Group Study in Patients With Alzheimer's Disease to Investigate the Safety and Tolerability of Repeated Subcutaneous Injections of CAD106.

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US Clinical Trial NCT00377351 – NIH – Sep 15, 2006

Confirmation of Self-Reported Incident ALS Cases in the AARP-Diet and Health (AARP-DH) Cohort

Amyotrophic Lateral Sclerosis (ALS) is a rare but rapidly progressive neurological disease that often results in death within a few years after the diagnosis. The incidence of ALS in the US is approximately 2.0/100,000/year and is age dependent. Ver...
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US Clinical Trial NCT00406029 – NIH – Nov 30, 2006

A Phase 2, 12-Week, Double-Blind, Dose-Finding, Placebo-Controlled Study to Assess the Efficacy and Safety of a Range of SCH 420814 Doses in Subjects With Moderate to Severe Parkinson's Disease Experiencing Motor Fluctuations and Dyskinesias

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US Clinical Trial NCT00714805 – NIH – Jul 10, 2008

Non-Invasive Measurement of GI Motility in Patients With ALS

This study will examine how much time it takes for the food to travel along the intestines from mouth or stomach (if you have a feeding tube) to the end of the large intestine using a special instrument that measures hydrogen gas in your breath. Dat...
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US Clinical Trial NCT02108769 – NIH – Apr 3, 2014

Induction of Salivary Neuromodulators by Chanting and Breathing Exercise

A. SPECIFIC AIMS SA1: Obtain a preliminary estimate of the extent to which a structured chanting exercise stimulates salivary secretion that contains quantifiable amounts of NGF in healthy subjects. SA2: Obtain a preliminary estimate of the extent...
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