Searching for keyword:"Migraine"

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US Clinical Trial NCT00237302 – NIH – Oct 7, 2005

A Comparison of the Efficacy and Safety of Topiramate Versus Placebo for the Prophylaxis of Migraine in Pediatric Subjects

Pediatric migraine headache is a common cause of severe recurring headaches in children, especially children between the ages of 5 and 15 years. These headaches can be disabling and tend to interfere with a child's daily activities, such as going to...
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US Clinical Trial NCT01125774 – NIH – May 17, 2010

A Six Month Phase II/III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Safety, Tolerability, and Efficacy of Telcagepant (MK-0974) for Prevention of Menstrually Related Migraine in Female Patients With Episodic Migraine

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US Clinical Trial NCT00777218 – NIH – Oct 21, 2008

Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine

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US Clinical Trial NCT03282227 – NIH – Sep 5, 2017

A Long-Term, Open-Label Study to Evaluate the Safety of M207 (Zolmitriptan Intracutaneous Microneedle System) in the Acute Treatment of Migraine

This is an open-label, twelve-month safety study. There is a screening period followed by a run-in period (14 to 21 days) to determine eligibility for treatment with study medication based on daily eDiary data collection. Qualified subjects will rec...
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US Clinical Trial NCT00285402 – NIH – Jan 31, 2006

Intranasal AST-726 Treatment for Prophylaxis of Migraine: A Placebo-Controlled Clinical Study

Migraine patients may experience repeated migraine attacks, lasting from four hours to three days or more. Each attack is characterized by severe pain, typically on one side of the head and often involves a number of other symptoms, including pain w...
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US Clinical Trial NCT01653522 – NIH – Jul 23, 2012

The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine

Increased inflammatory cytokines and matrix metalloproteinases (MMPs) have been recently implicated in migraine. Inflammation may be a key player in the pathophysiology of migraine by altering blood-brain barrier (BBB) function. As an inflammation i...
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US Clinical Trial NCT03004313 – NIH – Aug 30, 2011

Structural and Molecular Neuroplasticity in Migraine

To investigate interictal opioid receptor (MOR) binding potential (BPND) changes in migraineurs as compared to age/gender-matched healthy controls. To demonstrate that frequency of the headache attacks and severity of cutaneous allodynia levels in m...
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US Clinical Trial NCT01228552 – NIH – Oct 25, 2010

A Randomized Double Blind, Placebo Controlled Phase III Trial to Determine the Efficacy and Safety of Topical Intra-oral Ketoprofen for the Treatment of Acute Migraine

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US Clinical Trial NCT00334178 – NIH – Jun 5, 2006

A Multi-Center, Randomized, Parallel, Double-Blind, Placebo-Controlled Study in Evaluation the Efficacy and Safety of Laxymig® ER as Prophylactic Treatment in Patients With Migraine

The purpose of this study is to evaluate the efficacy and safety of Laxymig® ER compared with placebo in prophylactic monotherapy treatment of migraine headache. Four weeks baseline, following with 12 weeks treatment phase. Subjects migraine are re...
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US Clinical Trial NCT00904150 – NIH – May 17, 2009

A Case-control Study of the Molecular Genetics of Menstrual Migraine (Pure Menstrual and Menstrually-related Migraine)

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US Clinical Trial NCT03536936 – NIH – May 14, 2018

Oxygenation and Perfusion in Patients With Acute Migraine Attacks

The aim of the study is to demonstrate a possible correlation between areas of hypoperfusion and prominent cortical veins during migraine attacks. These focal ares of altered vascular supply of the brain will be evaluated for correlation with topog...
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US Clinical Trial NCT01257893 – NIH – Dec 8, 2010

Aspirin Resistance in Women With Migraine

To test the hypothesis that the rate of aspirin resistance is greater in women with episodic and chronic migraine than in women without migraine, a three-group, randomized, double-blind, placebo-controlled, crossover design will be used to test the...
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US Clinical Trial NCT00253175 – NIH – Nov 10, 2005

A Comparison Of The Efficacy And Safety Of Topamax® (Topiramate) Tablets Versus Placebo For The Prophylaxis Of Migraine

Topiramate is a medication that is widely used for the treatment of adult and pediatric patients with seizures and has been shown in preliminary studies to be effective for migraine prevention in adults. This is an outpatient, randomized, double-bli...
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US Clinical Trial NCT00210496 – NIH – Sep 13, 2005

Efficacy of AXERT (Almotriptan Malate) in the Acute Treatment of Migraine: A Pilot Study of the Potential Impact of Preventive Therapy With TOPAMAX (Topiramate)

Migraine afflicts greater than 28 million adults in the United States. Acute treatments, such as almotriptan malate, target the symptoms of a migraine attack. Preventive treatments, such as topiramate, primarily target the generation of attacks and...
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US Clinical Trial NCT03555214 – NIH – May 31, 2018

Efficacy of Manual Therapy for the Treatment of Chronic Migraine.

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US Clinical Trial NCT00804973 – NIH – Dec 5, 2008

A Safety, Tolerability, and Efficacy Study of LY2590443 in the Treatment of Acute Migraine Headache

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US Clinical Trial NCT03108469 – NIH – Mar 27, 2017

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of ISIS 546254 for Preventive Treatment of Chronic Migraine

This is a double-blind, placebo-controlled, randomized, multi-center study in subjects with chronic migraine. The study will consist of 7 office visits, 6 Sample collection visits and 3 phone call assessments. Subjects agreeing to participate in the...
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US Clinical Trial NCT03157739 – NIH – Apr 4, 2017

MigraineManager: An Individualized Self-Management Tool for Adolescents With Migraine

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US Clinical Trial NCT02643719 – NIH – Dec 29, 2015

Evaluation of a Behavioral Program for Migraineurs in the Emergency Department.

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US Clinical Trial NCT03939312 – NIH – May 3, 2019

A Phase 3, Multicenter, Open-Label 40-week Extension Study to Evaluate the Long-Term Safety and Tolerability of Oral Atogepant for the Prevention of Migraine in Participants With Episodic Migraine

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US Clinical Trial NCT00172094 – NIH – Sep 9, 2005

A Phase 2 Safety and Efficacy Study of NPS 1776 for the Acute Treatment of Migraine Headaches

Migraine, the most common cause of recurrent severe or disabling headache, is diagnosed on the basis of a clinical history of intermittent headache with autonomic, constitutional, and neurologic disturbances. Many antiepileptic drugs (AEDs) have de...
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US Clinical Trial NCT00407992 – NIH – Dec 4, 2006

An Italian, Randomized, Single-centre, Open-label Study of Occipital Nerve Stimulation in the Treatment of Chronic Migraine Headache

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US Clinical Trial NCT00820105 – NIH – Jan 8, 2009

A Phase 2B, Randomised, Double-blind, Placebo-controlled, Parallel Group, Dose-ranging, Multicentre Study to Investigate the Efficacy, Safety and Tolerability of the mGluR5 Negative Allosteric Modulator ADX10059 for the Prevention of Migraine

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US Clinical Trial NCT02176018 – NIH – Jun 25, 2014

A Randomized Pilot Study of Nuedexta for the Prevention and Modification of Disease Progression in Episodic Migraine

This is a double-blind, placebo-controlled, randomized, multi-center study to be conducted at the Headache Care Center in Springfield, MO and two other clinics in the United States. Approximately 45 subjects, 18 to 65 years of age, with frequent epi...
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US Clinical Trial NCT03335163 – NIH – Nov 3, 2017

The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users

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US Clinical Trial NCT03777059 – NIH – Dec 13, 2018

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Safety, and Tolerability of Oral Atogepant for the Prevention of Migraine in Participants With Episodic Migraine (Advance)

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US Clinical Trial NCT01804517 – NIH – Feb 23, 2013

Impact of a Nursing Intervention on the Clinical Evolution of Patients at a University Migraine Clinic

STUDY DESIGN: The goal of this study is to compare two treatment approaches for migraineurs. The first approach will be based on the physician only and is limited to fixed appointments (control group). The second approach will be based on a team in...
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US Clinical Trial NCT00212810 – NIH – Sep 13, 2005

TOPAMAX (Topiramate) Intervention to Prevent Transformation of Episodic Migraine: The Topiramate INTREPID Study

Chronic daily headache encompasses a frequent headache state in which the increased burden of pain further compromises quality of life and adversely impacts patients, their families, and health care providers. Approximately 5% of patients with migra...
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US Clinical Trial NCT00216606 – NIH – Sep 13, 2005

A Randomized Double-Blind Placebo Controlled Trial to Investigate the Efficacy and Tolerability of Topiramate in the Prophylaxis of Chronic Migraine

Previous studies have shown that topiramate is effective in preventing chronic migraine headaches. This study will start with a 4-week baseline period in which no treatment is given, followed by a 12-week period in which each patient's dose is adjus...
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US Clinical Trial NCT00742209 – NIH – Aug 26, 2008

Study MPX111381: A Dose-ranging Study Evaluating the Efficacy, Safety and Tolerability of GSK1838262 (XP13512) in the Prophylactic Treatment of Migraine Headache

MPX111381 is a multicenter, randomized, double-blind, placebo-controlled, parallel group, flexible-dose evaluation of GSK1838262 1200 mg/day, 1800 mg/day, 2400 mg/day and 3000 mg/day compared with placebo in the prophylactic treatment of migraine he...
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US Clinical Trial NCT00471952 – NIH – May 8, 2007

Maxalt 10mg Plus Caffeine 75mg in the Acute Treatment of Migraine Headache

Oral Maxalt has an extensive record of providing relief of acute migraine headache with 2 hours in the vast majority of patients, especially when undertaken as an early intervention strategy. Caffeine has been demonstrated to have analgesic effects...
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US Clinical Trial NCT02542605 – NIH – Sep 3, 2015

Phase I, Randomized, Parallel-group, Double-Blind, Placebo-Controlled, Single Dose Study to Evaluate the Blockade of CGRP Receptor by AMG 334 in Preventing PACAP-38 Induced Migraine-like Attacks in Migraine Patients

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US Clinical Trial NCT01578941 – NIH – Jan 5, 2012

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US Clinical Trial NCT03026101 – NIH – Dec 27, 2016

Understanding the Role of the External Carotid Artery in the Pathophysiology of Migraine Pain

The goals of the current study will be to demonstrate time-linked headache pain after super-selectively administration of vasodilatory medications to external carotid artery branches, and then observe vessel changes and presumed headache relief with...
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US Clinical Trial NCT00203268 – NIH – Sep 13, 2005

An Open Label Pilot Trial to Collect and Evaluate Data on the Use of Dihydroergotamine Mesylate in the Treatment of Two Migraine Attacks Associated With Cutaneous Allodynia

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US Clinical Trial NCT01161017 – NIH – Jul 10, 2010

Mechanism-based Choice of Therapy for Pain: Can Successful Prevention of Migraine be Coupled to a Psychophysical Pain Modulation Profile?

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US Clinical Trial NCT00959751 – NIH – Aug 14, 2009

Phase 2 Study of the Safety and Effectiveness of a Single Oral Dose of NXN-188 for the Treatment of Moderate to Severe Migraine Headache Without Aura

After study eligibility was confirmed and all screening procedures completed, subjects were randomized at Visit 1 to receive either NXN-188 600 mg or placebo in a 1:1 ratio. Study drug and diaries were dispensed, and subjects were instructed regardi...
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US Clinical Trial NCT01004835 – NIH – Oct 29, 2009

The Migraine and Pain Study GeneBank at Scripps Clinic Registry (MAPS)

It is estimated that over one-third of the world's population suffers from persistent or recurrent pain. Migraine is highly heritable and the majority of juveniles who suffer from the disorder have a mother or father who also have the disease. The b...
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US Clinical Trial NCT01230411 – NIH – Oct 27, 2010

A Double-blind, Placebo-controlled Pilot Study to Collect and Evaluate Data on the Use of Intravenous Ibuprofen in the Treatment of an Acute Migraine Attack

This is a pilot trial to collect and evaluate data on the use of intravenous ibuprofen (IVIb) in the treatment of an acute migraine attack. Data will be collected on the efficacy of IVIb in subjects who are treated with study medication between 2 an...
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US Clinical Trial NCT01450995 – NIH – Sep 2, 2011

Open-label, 6 Month Crossover Study Evaluating Migraine Patient Satisfaction Comparing Treximet to 2 Aleve and 100mg Imitrex Taken Concomitantly

A migraine headache is characterized by pain felt on one and sometimes both side(s) of the head. Other symptoms associated with a migraine headache may include nausea, vomiting, and sensitivity to light and sound. A migraine can last a few hours or...
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US Clinical Trial NCT01542307 – NIH – Feb 21, 2012

Normobaric Oxygen (NBO) Therapy in Acute Migraine

A total of 40 adult subjects will be enrolled, male and female. Subjects will be consented to inhale either Normobaric Oxygen (NBO) or Room air for 30 minutes at the start of their migraine attacks. Outcomes will be assessed during and after gas tre...
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US Clinical Trial NCT01286207 – NIH – Jan 27, 2011

Long-Term Exposure to Rizatriptan 5-mg and 10-mg Oral Tablet (Combined Protocols 022, 025, 029)

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US Clinical Trial NCT02021773 – NIH – Dec 20, 2013

A Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Parallel Group, Multi-Dose Study Comparing the Efficacy and Safety of Subcutaneous LBR-101 With Placebo for the Preventive Treatment of Chronic Migraine

Two distinct doses of subcutaneous LBR-101 administered monthly will be compared to placebo for safety and efficacy. The mean change from baseline in the number of cumulative headache hours measured at the 28-day period ending with week 12.
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US Clinical Trial NCT03266588 – NIH – Aug 23, 2017

A Multicenter, Open Label Long-Term Safety Study of BHV3000 in the Acute Treatment of Migraine

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EU Clinical Trial 2015-005674-37 – EMA – Nov 1, 2016

An Open-label, LonG-term, Safety Study of LAsmiDItan (100 mg and 200 mg) in the Acute Treatment Of MigRaine (GLADIATOR)

Main objective of the trial: Primary objective To evaluate the safety and tolerability of long-term intermittent use of lasmiditan 100 mg and of lasmiditan 200 mg, as the first and as a second dose, in the acute treatment of migraine.
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US Clinical Trial NCT00610727 – NIH – Jan 28, 2008

Tolerability, Safety and Pharmacokinetics of a Single Dose of Staccato™ Prochlorperazine for Inhalation in Normal, Healthy Volunteers

The objective of this study was to evaluate the tolerability, safety, and pharmacokinetics of a single, inhaled dose of prochlorperazine (PCZ), administered as 1 or 2 puffs in healthy young volunteers.
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US Clinical Trial NCT01146509 – NIH – Apr 28, 2009

An Open-Label, Multicenter, One-Year Extension Of The Evaluation Of The Efficacy And Safety Of Donepezil Hydrochloride (E2020) In Migraine Prophylaxis

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US Clinical Trial NCT00489476 – NIH – Jun 20, 2007

A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Single Dose Efficacy and Safety Study of Staccato® Loxapine for Inhalation in Patients With Migraine Headache

This study will enroll male and female patients with migraine headache with or without aura. The study will randomize ~160 patients, 1:1:1:1 to receive one of the following treatments: 1.25 mg Staccato Loxapine; 2.5 mg Staccato Loxapine; 5 mg Stacca...
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US Clinical Trial NCT00530517 – NIH – Sep 13, 2007

A Multi-Center, Open-Label, Single-Dose, Single-Arm Study to Evaluate the Usability of Subcutaneously Administered Sumatriptan Delivered Via the Intraject® System in Adult Patients During Acute Migraine Attack

This study will evaluate how patients will interact with the needle-free Intraject system during actual self-administration to the abdomen or thigh for treatment of migraine headache while outside the clinic.
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US Clinical Trial NCT01332500 – NIH – Mar 21, 2011

Treximet ™ Pharmacy Budget Impact Model Database Validation Study

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