Searching for keyword:"Microbiome"

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US Clinical Trial NCT02407184 – NIH – Mar 5, 2015

Potential Restoration of the Infant Microbiome

Human microbiota play an important role in the functioning of various organs, as well as the education of the immune system. Mammals have evolved to be born non-sterile, covered with the maternal vaginal bacteria that populate the maternal birth can...
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US Clinical Trial NCT03819179 – NIH – Jan 18, 2019

The Influence of Personal Care Products on the Skin Microbiome

Studies have shown that microbiome is important in skin conditions such as eczema, rosacea, acne, and many other skin conditions. Personal care products are widely used on a daily basis but it is not know how these personal care products shift the s...
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US Clinical Trial NCT03026621 – NIH – Jan 17, 2017

Examining the Change in Microbiome Diversity and Urine Metabolites After Lignite Extract Use

OBJECTIVES: The purpose of this study is to determine whether or not 'Restore' lignite extract mineral supplement impacts the microbiome composition of the mouth and gut. Additionally, participant urine samples will be examined to determine whether...
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US Clinical Trial NCT02655250 – NIH – Jun 19, 2015

The Neonatal Microbiome Study: Validity of Biologic Sample Collection Methods

In order to conduct a future study of the gut microbiome in a population living in a rural, low income setting, this validation study will be conducted to verify the validity of our proposed field collection methods for stool and breast milk samples...
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US Clinical Trial NCT03884361 – NIH – Mar 20, 2019

Does Elective Amniocentesis Change Vaginal Microbiome?

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US Clinical Trial NCT03388112 – NIH – Dec 23, 2017

Effects of Probiotics on the Gut Microbiome of Infants Treated With Antibiotics

This study aims to examin the impact of probiotics under 2 separate conditions, probiotics concurrent administration with antibiotic and probiotics administration during the recovery phase.Birth,7 days,14 days(or 21 days) and 42 days data will be co...
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US Clinical Trial NCT03058575 – NIH – Jan 24, 2017

A Randomized, Controlled, Crossover Study to Evaluate the Effects of a Novel Food Product Containing Microbiota Accessible Carbohydrates on the Human Microbiome and Associated Parameters

The human body is home to trillions of microbes, which have been shown to play important roles in many aspects of human biology, such as immune function and metabolism. Research in this area has primarily focused on the role that dietary factors hav...
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US Clinical Trial NCT02021799 – NIH – Jul 4, 2013

The Effect of Nutrition on the Microbiome in Pregnant Women and the Use of Micronutrient Supplemented Probiotic Yogurt to Improve Outcomes

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US Clinical Trial NCT03568734 – NIH – Nov 20, 2017

Cesarean Section and Intestinal Flora of the Newborn

Background The immune system is affected by the colonizing microbiome. The gut microbiome has been associated with a multitude of inflammatory diseases, such as the development of autoimmune diseases. The association between microbiome and allergic...
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US Clinical Trial NCT03942159 – NIH – Apr 29, 2019

Modification of the Human Colon and Oral Microbiome by Allogeneic HSCT in Recipients and Correlation With the Microbiome of the Donor

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US Clinical Trial NCT02867605 – NIH – Aug 9, 2016

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US Clinical Trial NCT03809260 – NIH – Jan 8, 2019

A Clinical Trial for Analysis of Intestinal Microbiome Affecting Pharmacokinetics, Pharmacodynamics, and Safety of Metformin in Healthy Volunteers

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US Clinical Trial NCT03851159 – NIH – Feb 19, 2019

Nyaditum Resae® (a Food Supplement) as a Co-adjuvant During First-line Treatment for Active Pulmonary Tuberculosis and Its Impact on the Gut Microbiota - a Pilot Double-blind Randomised Controlled Trial

About one tenth of the 1.7 billion individuals infected with Mycobacterium tuberculosis (Mtb) will progress to active tuberculosis (TB). This probability increases in people with human immunodeficiency virus (HIV) and other risk co-morbidities such...
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US Clinical Trial NCT03601936 – NIH – Jul 16, 2018

User Testing Protocol to Evaluate Performance of the Evivo Infant Gut Bifidobacterium Screening Test

This is a prospective, multi-center clinical study of the Evivo Infant Gut Bifidobacterium Screening Test ("Evivo Screening Test"). Lower levels of bifidobacteria in the infant gut have been linked to increased incidence of metabolic and inflammato...
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US Clinical Trial NCT03510936 – NIH – Apr 18, 2018

Effect of Probiotics on the Gut Mircobiome of Infants With Jaundice

This study aims to examin the impact of probiotics administration during the process of infants jaundice treatment and recovery phase.the recovery phase.Birth,7 days,14 days and 42 days data will be collected and put into analysis to provide some su...
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US Clinical Trial NCT03457857 – NIH – Feb 1, 2018

A Single Center, Five Week, Evaluator Blinded, Clinical Trial Evaluating Two Cleansing and/or Moisturizing Regimens on the Skin of Healthy Infants Using Clinical, Instrumental, D-Squame Tape, Microbiome and Parental Assessments

Skin cleansing has been demonstrated as a simple strategy to help keep skin healthy. There are many types of cleansing and moisturizing routines that have been shown to have different effects on the skin barrier such as reducing sebum and exogenous...
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US Clinical Trial NCT03157687 – NIH – May 15, 2017

Detection of Luminal and Mucosa-associated Microbiome in Healthy Controls vs. Local and Systemic Inflammation Under Mixed Diet

A dysbiosis of human gut microbiome is discussed in the pathogenesis of many disorders, also including gastrointestinal (e.g. inflammatory bowel disease, IBD) or liver diseases (e.g. liver cirrhosis) . A detailed analysis of intestinal bacterial pat...
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US Clinical Trial NCT03647449 – NIH – Jul 16, 2018

Examining the Effects of Juice Fasting

Up to 30 participants will be enrolled in the study and will be randomized into one of the three arms: the "juice fasting" arm, the "juice plus ad hoc" arm, and the "caloric restriction" arm. Participants will come into the lab for an initial visit,...
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US Clinical Trial NCT02617407 – NIH – Nov 6, 2015

Pilot Study -- Oral Microbiome and Dental Plaque Control With Livionex(R) in Children Undergoing Hematopoietic Stem Cell Transplantation (HSCT)

This is a prospective randomized (2:1) pilot study. A total of 75 children undergoing HSCT or chemo/radiation therapy for cancer treatment who are able to cooperate with saliva collection and dental exams will be enrolled into this study. Rational:...
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US Clinical Trial NCT03231332 – NIH – Jul 21, 2017

Long Term Effects of H.Pylori Eradication on Microbiome and Adverse Events

The current international guidelines and expert working groups are encouraging "search-and-treat" strategy for H.pylori to prevent gastric cancer1, 2. The highest yield of this approach is expected in countries with high incidence of gastric cancer...
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US Clinical Trial NCT01724736 – NIH – Nov 6, 2012

A Pilot Study to Determine the Effect of a Cobiotic Formulation on the Fecal Bacteroidetes: Firmicutes Ratio in Pre-Diabetic Subjects.

Human gut microbiome appears to be involved in the regulation of metabolic processes, including digested food components, absorption of fat, metabolism of drugs, and conversion of indigestible foods or partially digested food ingredients to molecule...
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US Clinical Trial NCT03975764 – NIH – Jun 2, 2019

Fecal Microbiota in Preterm Birth

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US Clinical Trial NCT02560246 – NIH – Sep 23, 2015

Maternal Gut Microbiome (MGM) Study of Diet, the Gut Microbiome and Preterm Birth

While dietary guidelines about intake of specific nutrients in pregnant women are well-established, surprisingly little is known about dietary eating patterns or nutritional risk factors for SPTB. In data from two large nationally-representative Eu...
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US Clinical Trial NCT03181269 – NIH – Jun 6, 2017

Human Milk and Infant Intestinal Microbiome Study

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US Clinical Trial NCT03812497 – NIH – Jan 17, 2019

Interplay Between Pediatric Obesity Related Plasma Metabolite Profile and Gut Microbiota

Many recent studies have suggested that dysbiosis of the gut microbiome might related to obesity. There is growing evidence that the composition of gut microbiome changes in childhood obesity compared to normal-weight children, and it is attracting...
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US Clinical Trial NCT01942577 – NIH – Sep 11, 2013

Comprehensive Microbiome Survey of Preterm Infants

The long term goals of this project are to understand what constitutes protective and beneficial gut and skin microbial communities and determine approaches to foster and preserve these communities. By defining the gut and skin-associated microbiolo...
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US Clinical Trial NCT02734589 – NIH – Mar 28, 2016

Fecal Transplantation Using a Novel Conditioning Method for Donor and Recipient in Mild to Moderate Treatment Refractory Colitis in Inflammatory Bowel Disease

The first exploratory phase will take place in 34 subjects aged 18-60, with refractory established UC, over 12 weeks. Study type- It will be an open label 3 arm multicenter randomized controlled single blinded study, with review of endoscopic activi...
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US Clinical Trial NCT03388411 – NIH – Dec 19, 2017

Nutritional Intake, Metabolic Abnormalities and Gut Microbiome in Children

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US Clinical Trial NCT03584360 – NIH – Jun 18, 2018

Study Role of the Local Treatments on the Microbiome Modulation in the Psoriatic Skin. Study Monocentric, Interventional, Randomized and Single-blind

To date, there is no data on the impact of topical treatments in skin microbiome and in innate cells in psoriasis lesions. However, topical treatments remain in most cases the first and the more widely used option for mild psoriasis which represent...
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US Clinical Trial NCT03450395 – NIH – Jan 29, 2018

The Effect of Oats Containing 1.4g Beta Glucan on Fecal Bacterial Population(s) and Plasma Cholesterol in Healthy Adults With Elevated Cholesterol Levels: a Randomized, Single-blind, Placebo-controlled, Cross-over Study

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US Clinical Trial NCT03476447 – NIH – Mar 19, 2018

Rescuing the Microbiome Effectively With Different Doses of B. Infantis in Infants (The REMEDI Study)

Mother-infant dyads will be enrolled when the infant is 2-4 months of age. A 1-week lead-in period will be utilized to collect baseline microbiome samples and for the completion of daily and weekly feeding and health logs. Subjects that meet eligibi...
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US Clinical Trial NCT03218579 – NIH – Jul 13, 2017

Endoscopic Assessment and Prediction of Microbiome-modifying Interventions

The investigators would like to examine the extent of rehabilitation of the composition and functioning of the intestinal bacteria in healthy people after the consumption of antibiotics. Since the digestive mocus enables the connection between the...
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US Clinical Trial NCT03296631 – NIH – Aug 1, 2017

Phages Dynamics and Influences During Human Gut Microbiome Establishment

Over the last decade, the role of microorganisms residing in human intestines has been intensively studied. The intestinal microbiome includes bacteria, viruses, fungi and archaea. The importance of microbiome to human health is highlighted by the o...
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US Clinical Trial NCT03501082 – NIH – Nov 21, 2017

Rewilding the Human Gut: Reintroduction of the Species Lactobacillus Reuteri

There is now substantial evidence that industrialization has resulted in substantial decrease in the bacterial diversity of the gut microbiota (Segata, 2015), likely due to a combination of factors such as use of antibiotics, modern clinical practic...
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US Clinical Trial NCT03371511 – NIH – Dec 7, 2017

Sources of Bacterial Contamination in Human Milk Samples From the Milk in Life Conditions (MiLC) Trial

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US Clinical Trial NCT03409757 – NIH – Dec 5, 2017

Velphoro and Impact on the Oral Cavity and Gut Microbiome

The aim of this study is to investigate potential changes in the microbiome of the oral cavity and/or gut in patients with hyperphosphatemia following Velphoro® intake for one month. The principal intention of this study is to assess consequences of...
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US Clinical Trial NCT01977183 – NIH – Oct 11, 2013

Effects of MSPrebiotic on Gut Health in the Elderly

To assess the impact on the potato resistant starch on the microbiota, pyrosequencing will be performed on stool samples to determine the original composition and assess any changes over the study period. In addition the impact of the potato resista...
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US Clinical Trial NCT03403972 – NIH – Oct 15, 2017

A Clinical Trial to Evaluate the Effects of the Environmental Change in Intestine by Antibiotics on the Pharmacokinetic Characteristics of Simvastatin in Healthy Male Volunteers

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US Clinical Trial NCT03605108 – NIH – Jul 3, 2018

The Influence of Oral Probiotics on the Microbiome and Lipidome

Antibiotics are widely used within dermatology for the treatment of chronic skin conditions such as acne, rosacea, and atopic dermatitis. Previous studies have shown that oral probiotics may be beneficial for skin disesaes such as atopic dermatitis...
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US Clinical Trial NCT03748017 – NIH – Oct 22, 2018

The Probiotic for Oral Health (PRO Health) Study

Upon enrollment, healthy adults will enter a 1-week lead-in period which serves as an opportunity to collect baseline saliva samples and complete daily logs. Subjects that meet eligibility criteria on Day 7 will be randomized into 1 of 2 groups, rec...
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US Clinical Trial NCT03841994 – NIH – Feb 1, 2019

Association of Gut Microbiome With Neonatal Complications and Neurodevelopment in Preterm Infants

The purpose of this study was to investigate the effect of the formation of gut microbiome on the neonatal disease and the prognosis of neurodevelopment in preterm infants.
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US Clinical Trial NCT03396198 – NIH – Dec 22, 2017

An Observational Study of Intestinal Flora in Infants

The gastrointestinal microbiome is believed to be critically important for infant growth and development. As we all know, the gut microbiota can influence gut maturation, metabolic, immune and brain development in early life. Host genotype, gestatio...
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US Clinical Trial NCT03119272 – NIH – Apr 4, 2016

Microbiome-mediated Weight, Anxiety, and Stress Dysregulation in Anorexia Nervosa

Anorexia nervosa (AN), a psychiatric disorder characterized by extreme weight dysregulation commonly presents with comorbid anxiety. Therapeutic renourishment in AN is based primarily on clinical opinion and guidelines, with a weak evidence base. Co...
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US Clinical Trial NCT03373721 – NIH – Dec 11, 2017

Gut Microbial Succession of Preterm Infants and Full-term Infants at Early Life

Premature birth is a global clinical problem. Early colonization and development of the neonatal gut microbiome is critically important with a profound impact on the host lifelong health. V3-V4 region of 16S rRNA amplicons of 581 stool DNA will be s...
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US Clinical Trial NCT02972463 – NIH – Nov 18, 2016

A Randomized, Double-blind, Placebo-controlled, Parallel Dose Ranging Study on the Influence of IgY Max on Inflammatory Markers and the Gut Microbiome

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US Clinical Trial NCT02693028 – NIH – Oct 12, 2015

Lactobacillus Reuteri Feasibility Study on Probiotic Lozenges, Probiotic Chewing Gum and Probiotic Capsules and Perinatal Microbiome Seeding During Pregnancy

The purpose of this project is to better understand the following issues: 1. How does bacteria transmit from the mother to the fetus and placenta during pregnancy and to the infant during the first 2-6 weeks after birth? 2. Does colonization of th...
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US Clinical Trial NCT02794649 – NIH – May 25, 2016

Descriptive Analysis of Gut Microbiome Alterations in Hyperoxaluric Patients

Kidney stones affect as much as 10% of the US population with the most common type of stones made of calcium oxalate. Calcium and oxalate are present in the urine and can bind to each other, and form calcium oxalate kidney stones. Oxalate is absorbe...
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US Clinical Trial NCT03610477 – NIH – Jul 20, 2018

Effect of Normal Dietary Intake and Medium Chain Triglycerides Supplementation on the Human Microbiome

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US Clinical Trial NCT02970877 – NIH – Jun 17, 2016

Fecal Microbiota Transplant From Healthy Lean Donors to Morbidly Obese Individuals: Effect on Insulin Resistance and Other Obesity-related Parameters. A Randomized Controlled Trial.

The coupled disorders of morbid obesity and type 2 diabetes (T2D) are a major and growing public health problem in Canada. The Public Health Agency of Canada 2011 report, Obesity in Canada, showed that 5.1% and 2.7% of Canadians had obesity class II...
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US Clinical Trial NCT02343731 – NIH – Jan 13, 2015

Dogs as Probiotics to Enhance the Health and Emotional Well-Being of Elderly Adults

One of the most amazing scientific discoveries of the last decade has been the important roles that the trillions of micro-organisms in our guts (called the "microbiota") play in promoting good physical health and emotional well-being. Unfortunately...
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