Searching for keyword:"Inflammation"

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US Clinical Trial NCT01214174 – NIH – Sep 21, 2010

A Multicenter, Randomized, Double-masked, Dose-ranging, Phase 2 Study to Evaluate the Efficacy and Safety of IBI-10090 in Treating Inflammation in Cataract Surgery Patients

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US Clinical Trial NCT00385723 – NIH – Oct 10, 2006

Omega-3 Dietary Supplementation, Immune Function, and Mood

The beneficial effects of fish oil (or eating fish more frequently) include reductions in triglycerides, blood pressure, and heart rate, as well as increases in HDL cholesterol, the "good" type of cholesterol. In addition, certain aspects of immune...
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US Clinical Trial NCT02938650 – NIH – Oct 17, 2016

Assessing the Role of Nitrosomonas Eutropha on Nitrolipids in the Skin

We are looking to see how the nitrosomonas alters nitrolipids in the skin and the inflammatory cytokines of the skin. We will be using healthy subjects over the course of 2 weeks. Subjects will be using a neutral cleanser for one week prior to the...
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US Clinical Trial NCT00961623 – NIH – Aug 17, 2009

Characterizing Knee Pain and Response to Surgery Using Local Biomarkers

Lavage of the operative and contralateral knee for comparison are performed under anesthesia prior to arthroscopy by the infusion of 10cc sterile saline into the knee joint followed by the immediate withdrawal into the syringe, and storage at -80°C...
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US Clinical Trial NCT01161394 – NIH – Jul 12, 2010

Effect of Pioglitazone on Oxidative Load, Inflammatory End-Points and Vascular Reactivity in Obese Non-Diabetic Patients: A Dose Ranging Study

This is a single center, open labeled study. A total of 24 obese patients will be recruited to participate in this study. The study will have three groups of 8 patients each. Subjects will be enrolled into each group by alternate recruitment. Subjec...
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US Clinical Trial NCT00311064 – NIH – Apr 4, 2006

Inflammatory Response and Pregnancy Outcome in Women With Type 2 Diabetes or Only Overweight. The Influence of Physical Activity

Material and Method: This study falls in two fields: First 80 pregnant women with type 2 diabetes are followed with determination of cytokines and factors of the metabolic syndrome throughout the pregnancy. The correlation between these variables...
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US Clinical Trial NCT01527604 – NIH – Jan 30, 2012

Effects of Avenanthramide-enriched Oats on Inflammation in Obese Adults With Central Adiposity: A Randomized Clinical Trial

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US Clinical Trial NCT02370966 – NIH – Feb 12, 2015

Berry Intake - Effects on Systemic and Oral Inflammation

Summary About 10-15 % of the adult population in Sweden suffers from periodontitis, which is an inflammatory response to certain oral bacteria. The first stage of periodontitis is termed gingivitis, which is clinically defined by swollen tissue, red...
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US Clinical Trial NCT02916589 – NIH – Sep 26, 2016

The Impact of Diet on Oral Health in Overweight Individuals With Type 2 Diabetes

Obesity and diabetes mellitus Obesity is one of our most serious public health issues (National Food Agency, 2016). In the Swedish adult (16-84 years) population, about 35% are overweight and almost 15% are obese (Statistics Sweden). The most common...
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US Clinical Trial NCT01073982 – NIH – Feb 12, 2010

Efficacy of Tart Cherry Juice to Reduce Pain and Inflammation Among Patients With Inflammatory Osteoarthritis

Numerous antioxidant and anti-inflammatory agents have been identified in tart cherries, and a study among healthy, non-exercising individuals demonstrated that cherry consumption decreased serum inflammatory biomarkers after 14 days. Osteoarthritis...
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US Clinical Trial NCT00361283 – NIH – Aug 4, 2006

Systemic Immunomodulatory Effects and Pharmacogenetics of Atorvastatin in Early Atherosclerosis

All subjects received 16 weeks of Atorvastatin after a two week run in. Key dependent variables were the 16 week value minus the baseline value (post run-in). Last observation carried forward was used for missing values. The key comparisons are for...
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US Clinical Trial NCT00791323 – NIH – Nov 12, 2008

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US Clinical Trial NCT02430064 – NIH – Apr 24, 2015

Effects of Chronic Intake of Processed Foods on Circulating Inflammatory Markers in Healthy Men

This study aims to investigate the effects of diets enriched or depleted in foods at high risk of containing pro-inflammatory bacterial molecules, on markers of inflammation and cardiometabolic risk in healthy men. The study design is an interventio...
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US Clinical Trial NCT01601821 – NIH – May 3, 2012

An Open Label Comparative Study Of De Novo Renal Allograft Recipients Receiving CSA + MMF + Corticosteroids Versus CSA + Rapamune + Corticosteroids With Further CSA Elimination In The Rapamune Arm With The Introduction Of MMF

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US Clinical Trial NCT03244462 – NIH – Aug 7, 2017

Open Label, Randomized, Cross-over Study to Explore the Pharmacokinetics of BAY1834845 After Oral and Intravenous Dosing, Including Food Effect and Absolute Bioavailability (Part A), and to Investigate the Effect of BAY1834845 on the Pharmacokinetics of Orally Administered Methotrexate (Part B) in Healthy Male Subjects

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US Clinical Trial NCT02920502 – NIH – Sep 9, 2016

Effect of a One Time Dose of Cholecalciferol on Serum Concentration of 25-Hydroxyvitamin D and Macrophages

3.4.1 Study Medication (Vitamin D/Placebo): Patients will be blocked randomized into one of four groups using a balanced assignment. The target number of patients is 20, with five patients who have successfully completed all assessments in each grou...
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US Clinical Trial NCT02512107 – NIH – Jul 1, 2015

The Effect of Juice Plus+ on the Microbiome, Intestinal Permeability and Inflammatory Status of Psychologically Stressed Individuals With High Body Mass Indices

An anticipated eighty critical care, female health care professionals will be recruited. This population has been shown to have a high occupational stress load and have increased risk for post-traumatic stress disorder (PTSD). The subjects will be p...
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US Clinical Trial NCT01420328 – NIH – May 26, 2011

To Study the Effect of Vytorin on Intracellular Lipid and Inflammation in Obese Subjects

Following the first demonstration by our group that macronutrient (glucose, cream and a high fat high carbohydrate meal) intake results in increased ROS generation and oxidative stress at the cellular and molecular level, the investigators have now...
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US Clinical Trial NCT00429923 – NIH – Jan 31, 2007

A Phase 3 Multicenter, Randomized, Double-Masked, Placebo-Controlled Study of the Safety and Efficacy of Difluprednate in the Treatment of Inflammation Following Ocular Surgery

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US Clinical Trial NCT00407225 – NIH – Nov 29, 2006

Phase 2a Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Postoperative Inflammation After Cataract Surgery

The objective is to assess the efficacy and safety of 0.002% and 0.05% difluprednate ophthalmic emulsions in patients with postoperative inflammation after cataract surgery (implantation of intraocular lens). In addition, the evaluation system for a...
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US Clinical Trial NCT03029546 – NIH – Jan 12, 2017

The Effect of Acute Glucose Loading on Level of Expression of Advanced Glycation End Products in Women Screened for Gestational Diabetes During Pregnancy

A. Research Design Participants will be identified at the time of their prenatal care visit (24-28 weeks GA). The investigators will ask permission for participation in the research protocol. A waiver of HIPPA has been added to the protocol to expla...
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US Clinical Trial NCT00406341 – NIH – Nov 29, 2006

Phase 3 Confimatory Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treament of Postoperative Inflammation

The objective of this phase 3 study is to assess the efficacy and safety of 0.05% difluprednate ophthalmic emulsion in patients with intraocular postoperative inflammation.
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US Clinical Trial NCT00430092 – NIH – Jan 30, 2007

A Phase 3 Multicenter, Randomized, Double-Masked, Placebo-Controlled Study of the Safety and Efficacy of Difluprednate in the Treatment of Inflammation Following Ocular Surgery

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US Clinical Trial NCT00532961 – NIH – Sep 20, 2007

A Randomized, Double-masked, Parallel Comparison of Ocular Tolerance and IOP Effects of Zylet vs TobraDex Administered Four Times Daily for Four Weeks in Healthy Volunteers

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US Clinical Trial NCT00616070 – NIH – Feb 4, 2008

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US Clinical Trial NCT01527617 – NIH – Jan 30, 2012

The Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress in Healthy But Overweight/Obese Subjects: A Randomized Clinical Trial

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US Clinical Trial NCT02587507 – NIH – Oct 22, 2015

Proteomic Analysis of the Peripheral-Blood Mononuclear Cells Response After a High-Fat, High-Carbohydrate Meal With or Without Orange Juice in Healthy Subjects

BACKGROUND: A high-fat, high-carbohydrate meal (HFHC) induces an increase in inflammation in peripheral-blood mononuclear cells in healthy subjects. A few studies have shown that orange juice, when consumed together with the high-fat meal, is able...
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US Clinical Trial NCT01749826 – NIH – Nov 9, 2009

Inflammatory Responses to Acute and Chronic Opioid Exposure in Humans

We are interested in learning how the immune system and the inflammation process is effected by acute and chronic opioid exposure. Preliminary evidence in animal models show that acute opioid exposure leads to decreased inflammatory responses, while...
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US Clinical Trial NCT01601106 – NIH – Oct 13, 2011

A Phase I/II, Single-Center, Randomized, Placebo-Controlled Study Evaluating the Therapeutic Efficacy of Intravenously Injected PEG-liposomal Prednisolone Sodium Phosphate (Nanocort®) in Subjects With Severe Inflamed Carotid or Aortic Atherosclerosis Plaques

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US Clinical Trial NCT02536781 – NIH – Aug 22, 2015

Khon Kaen University Ethics Committee in Human Research

Multiple inflammatory lesions caused from orthodontic treatments are commonly found in these patients and the irritations from the insertion of the orthodontic wire are hard to apply the topical cream or gel. Standard treatment to prevent oral mucos...
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US Clinical Trial NCT03262051 – NIH – Aug 21, 2017

Impact of Acute and Chronic Inflammation on Cytochromes P450 Activity Measured With Dried Blood Spot

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US Clinical Trial NCT00264186 – NIH – Dec 9, 2005

Impact of rhCu/Zn SOD on Inflammation-Induced Impairment of Vascular Reactivity

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US Clinical Trial NCT00616993 – NIH – Feb 4, 2008

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US Clinical Trial NCT00406497 – NIH – Nov 29, 2006

Phase 2a Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Postoperative Inflammation

The objective is to assess efficacy endpoints in comparison with 0.1% BM ophthalmic solution, prior to investigation of the efficacy and safety of 0.05% DFBA ophthalmic emulsion in the treatment of postoperative intraocular inflammation.
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US Clinical Trial NCT01762787 – NIH – Nov 28, 2012

A Randomised, Single Blind, Placebo-Controlled, Cross-over, Phase 1 Methodology Study to Validate the Cantharidin Blister Model in Healthy Male Volunteers

The purpose of this study is to refine the cantharidin-induced blister assay. The cantharidin-induced skin blister assay may be a valuable tool for evaluation of the pharmacodynamic effects of novel anti-inflammatory drugs in healthy volunteers, par...
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US Clinical Trial NCT01534572 – NIH – Feb 13, 2012

Significance of Synbiotics on Inflammation and Proliferation of Colonic Mucosa

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US Clinical Trial NCT01570205 – NIH – Mar 29, 2012

The Safety, Tolerability and Pharmacokinetics of a Single Intravenous Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Male Volunteers in a Randomized, Double Blind, Placebo Controlled, Dose Escalating Phase I Study

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US Clinical Trial NCT03524690 – NIH – May 2, 2018

Effects of Severe Negative Energy Balance on Inflammation During a Simulated Military Operation

Endurance exercise elicits skeletal muscle and systemic inflammation. Inflammation in response to endurance exercise is normally attenuated with adequate rest and recovery as skeletal muscle adapts with training. However, performing repeated bouts o...
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US Clinical Trial NCT03626870 – NIH – Aug 3, 2018

Effects of Resistin on Neutrophil Function

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US Clinical Trial NCT01244360 – NIH – Nov 17, 2010

The Effects of Resveratrol Supplementation on Measurements of Health and Human Performance

Measurements - blood laboratory parameters - cognitive assessment changes - body composition changes - vascular endothelial response
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US Clinical Trial NCT00227487 – NIH – Sep 26, 2005

The Evaluation of Intestinal Inflammation and Carbohydrate Digestion in Children With Autistic Spectrum Disorders

Gastrointestinal disorders in children with autism receive little attention. However, symptoms such as abdominal pain, diarrhea, constipation, and flatulence have been considered contributing to the behavioral problems. These symptoms are associated...
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US Clinical Trial NCT01547949 – NIH – Feb 24, 2012

Efficacy of Tart Cherry Juice in Reducing Muscle Injury and Biomarkers of Muscle Damage Among Healthy Adults

Numerous antioxidant and anti-inflammatory agents have been identified in tart cherries, and a study among healthy, non-exercising individuals demonstrated that tart cherries decreased post-exercise weakness and muscle pain. The purpose of this stud...
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US Clinical Trial NCT03356626 – NIH – Nov 24, 2017

Comparison of Perioperative Outcomes Between Bipolar Sealing Device and Ultrasonic Shears During Laparoscopic Gastrectomy for Early Gastric Cancer

To find out which instrument can be much better for laparoscopic gastrectomy among Harmonic scalpel, Ligasure Maryland, Thunderbeat comparing postoperative CRP level in each group 1. post operative 2nd day CRP level 2. post operative 4th day CRP...
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US Clinical Trial NCT01310127 – NIH – Mar 1, 2011

Clinical Outcomes of Bromday (Bromfenac Ophthalmic Solution) 0.09% QD vs. Nevanac (Nepafenac Ophthalmic Suspension) 0.1% TID for Treatment of Ocular Inflammation Associated With Cataract Surgery

Two topical NSAIDs currently approved for postoperative treatment of pain and inflammation in cataract surgery are bromfenac 0.09% and nepafenac 0.1%. Both purport to treat ocular inflammation by acting as a potent inhibitor of COX-1 and COX-2 enzym...
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US Clinical Trial NCT00969995 – NIH – Sep 1, 2009

Identification of Inflammatory Markers in Migraine Patients

Migraine is prevalent in 10-12% of the population, with female preponderance (1). Migraine may cause a significant distress and reduction of the quality of life of the patients, of whom in almost a third of them the migraine attack reduces the abili...
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US Clinical Trial NCT00780520 – NIH – Oct 24, 2008

The Effect of Glutamine Infusion on the Inflammatory Response and HSP-70 in BMNCs During Human Experimental

Glutamine levels have been shown to decrease substantially with severe sepsis and this has been connected with increased mortality. Therefore, in the present study, we infused either saline or Alanine-glutamine during an endotoxin challenge and meas...
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US Clinical Trial NCT02069431 – NIH – Feb 10, 2014

Effects of Oxytocin on Physical and Cognitive Functioning in the Elders

Overview: - Initial screening visit - 3 baseline study visits - 4-week treatment phase - 3 study visits after treatment - Follow-up phone contact All study visits will be conducted at the Institute on Aging or the McKnight Brain Institute at t...
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US Clinical Trial NCT02330380 – NIH – Dec 30, 2014

Comparative Effectiveness of Psoriasis Treatments on Systemic Inflammation

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US Clinical Trial NCT01130714 – NIH – Jan 6, 2010

Effectiveness of a Resistance Training Program on Inflammatory Markers and Chemotherapy Completion in Lung Cancer Patients on Chemotherapy

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US Clinical Trial NCT00519779 – NIH – Aug 21, 2007

Academic Stress and Proinflammatory Cytokines: Omega-3 Intervention

This study will examine how supplementation with omega-3 polyunsaturated fatty acids (key fish oil components) affects immune and mood responses to examination stress. This study will examine these outcomes in medical students during academic examin...
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