Searching for keyword:"Dysbiosis"

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US Clinical Trial NCT03659240 – NIH – Sep 3, 2018

Prebiotic Effects of a Polyphenol-rich Food Product

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US Clinical Trial NCT03163784 – NIH – May 18, 2017

SHIFT: Studying HIV Immunology After Fecal Transplant

This study is designed to test the safety and tolerability of Fecal Microbiota Transplant (FMT) in HIV infected individuals on stable antiretroviral therapy (ART). Additionally, the study will examine potential effects of FMT on HIV immune activatio...
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US Clinical Trial NCT03657485 – NIH – Aug 31, 2018

Probiotic Supplementation in the Term Newborns Delivered by Caesarean Section: a Randomized, Prospective Clinical Trials

The aim of the study was to assess the effect of the probiotic supplementation on microbiota composition of the gut in healthy newborns delivered by CS. We studied colonization of GI tract on the day of discharge from hospital and after a month of l...
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US Clinical Trial NCT02693327 – NIH – Feb 16, 2016

Microbiome and the Gut-Brain Axis

People living with serious mental illnesses have far shorter life expectancy due to various attending medical disorders. Vast knowledge gaps exist regarding microbial taxa responsible for governing various the human states of health or morbidity or...
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US Clinical Trial NCT02839317 – NIH – Jul 13, 2016

Comparison of Fecal Microbiota Between Patients With Early and Late Crohn's Disease and Relationship With Different Genetic and Serological Profiles

The primary aim is to describe by principal component analysis and compare the gut microbiota between subgroups of paediatric-onset (n=75), elderly-onset CD patients (n=75) and control subjects (75 paediatric control and 75 elderly control subjects...
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US Clinical Trial NCT03897777 – NIH – Jan 26, 2019

Effects of Exercise on Hypertension and Gut Dysbiosis in African Americans

African Americans (AA) have the greatest burden of hypertension and elucidating the pathogenesis of this racial disparity is important for amending treatment strategies. Gut microbial dysbiosis has been linked to hypertension and has been characteri...
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US Clinical Trial NCT03554278 – NIH – May 3, 2018

Alteration of Stool Microbiota in Preterm Infants Less Than 32 Weeks With Anemia, and Following Blood Transfusion

Necrotizing enterocolitis (NEC) is a leading cause of death in preterm infants, yet the disease mechanism is not well understood. Among the factors that have been studied are the change in stool microbiota (dysbiosis), severe anemia, and transfusion...
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US Clinical Trial NCT03675048 – NIH – Sep 14, 2018

Single-center, Prospective, Randomized, Double-blind, Placebo-controlled Clinical Trial on Estimating the Effect of Probiotic Strain Lactobacillus Reuteri DSM 17938 on Gut Microbiota Modulation in Infants Born by Caesarean Section

This is a single-center prospective randomized double-blind placebo-controlled clinical study. The planned duration of the study for each included infant will be 16 weeks, 4 weeks of study drug intake and 12 weeks of follow-up. 140 healthy infants b...
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US Clinical Trial NCT03747991 – NIH – Nov 16, 2018

Effect of Histamine-2 Receptor Antagonists on the Microbiome of Full Term Infants

Gut microbiota dysbiosis is associated with diseases ranging from localized gastrointestinal disorders to neurologic, respiratory, metabolic, hepatic, and cardiovascular illnesses. The microbial colonization of the infant gut is known to play a key...
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US Clinical Trial NCT03857360 – NIH – Feb 13, 2019

Effectiveness of PENTABIOCEL in Clinical and Laboratory Recovery of Children With Celiac Disease: A Randomized Double Blind Placebo Controlled Trial

Celiac disease (CD) is an intestinal inflammatory condition characterized by permanent intolerance to gluten, a protein complex present in wheat, barley, and rye, in genetically predisposed subjects. In the early phase of the disease, specific autoa...
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US Clinical Trial NCT03265639 – NIH – Feb 17, 2017

Prebiotics in Peritoneal Dialysis

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US Clinical Trial NCT03545243 – NIH – Apr 24, 2018

Effect of Proton Pump Inhibitors on the Duodenal Microbiome in Healthy Volunteers

PPIs are frequently (over-)prescribed with potential adverse events, especially in the long term. As C. difficile and CAP are important causes of morbidity, mortality and healthcare costs, it is important to study the underlying mechanisms of PPI-in...
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US Clinical Trial NCT03758144 – NIH – Nov 16, 2018

Rifaximin Improves Insulin Resistance in Metabolic Syndrome and Reduces Insulin Requirement in Type 2 Diabetes

Accumulating evidence had linked metabolic syndrome and diabetes to dysequilibrium in gut microbiota, which are a critical regulator of host metabolism and immune responses. gut microbiota interacts with host signaling pathways, leading to modulatio...
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US Clinical Trial NCT03569904 – NIH – Jun 14, 2018

Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis

Therapeutic advances and the organization of care within the "CRCM" have led to an overall improvement in the management of cystic fibrosis. The protein therapies that have marked this progression only target certain genes and concern a small number...
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US Clinical Trial NCT03973996 – NIH – May 30, 2019

Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome

Tea is the most abundantly consumed prepared beverage in the world. Green tea, containing catechins, exerts antiinflammatory activities. However, a fundamental gap exists concerning its intestinal-level targets that can prevent metabolic syndrome (M...
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US Clinical Trial NCT03802890 – NIH – Jan 10, 2019

Microbial Dysbiosis in the Pathogenesis of Rheumatoid Arthritis: Using Metagenomics to Predict Methotrexate Efficacy

Methotrexate is often the first drug of choice for patients with early rheumatoid arthritis (RA), but its efficacy is highly variable and it can lead to severe side effects. There are currently no reliable predictors of methotrexate efficacy for peo...
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US Clinical Trial NCT03946176 – NIH – May 9, 2019

XUANRO4 - NATURE 3.2 - Nuovo Approccio Per la Riduzione Delle Tossine Uremiche Renali, REGIONE PUGLIA - FSC 2007-2013 Ricerca. Intervento "Cluster Tecnologici Regionali"

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US Clinical Trial NCT03278912 – NIH – Sep 9, 2017

Natural History of Intestinal Inflammation in Patients With Primary Immune Dysregulations

Over 1 million people suffer from IBD in the United States. Although the exact pathogenesis is unclear, IBD results from an inappropriate inflammatory response to intestinal microbes which is influenced by the environment in a genetically susceptibl...
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US Clinical Trial NCT02826330 – NIH – Jun 29, 2016

Evidence of Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn's Disease: Family Studies and Relations With a Particular Genetic Profile and Serological. Comparison of Affected Individuals, Their Siblings and Healthy Controls.

Crohn's disease is a chronic inflammatory bowel disease associating flares and remission periods. Its etiology is unknown and there are no specific therapy. CD affects young patients and has a major impact on quality of life. There are few populatio...
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US Clinical Trial NCT03955159 – NIH – Apr 15, 2019

Effects of Probiotic Supplementation on Autonomic Nervous System Imbalance and Vascular Changes in Hypertensive Menopausal Women: RANDOMIZED CLINICAL TRIAL

After randomization, subjects will be included in their intervention group for a period of three months with initial and final evaluations. The study will evaluate the effects and possible benefits of probiotic supplementation on the functioning of...
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US Clinical Trial NCT03493529 – NIH – Mar 8, 2018

Microbiome and Endometrial Receptivity in Obese Infertile Women

The main objective of our study is to compare the composition of the endometrial microbiota between patients with normal weight and patients with obesity. A. Secondary Objectives/research questions - To analyze the composition of the digestive mic...
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US Clinical Trial NCT03775824 – NIH – Dec 11, 2018

Faecal Analyses in Rheumatoid Arthritis Therapy: An Prospective Observational Study of the Intestinal Microbiome in Patients With Rheumatoid Arthritis Receiving Immunosuppressive Therapy

Methotrexate (MTX) and tumor necrosis factor (TNF) -inhibitors are two efficient medications for the treatment of rheumatoid arthritis. In a substantial number of cases however, these medications remain ineffective. At present, the scientific commun...
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US Clinical Trial NCT03269617 – NIH – Aug 1, 2017

PreforPro: A Randomized, Placebo Controlled Crossover Study

The goal of this study is to see if consumption of PreforPro, a commercially available prebiotic dietary supplement consisting of a mixture of bacteriophages, improves gut bacteria profiles in individuals relative to a placebo control. Secondary out...
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US Clinical Trial NCT03795233 – NIH – Nov 21, 2018

Fecal Microbiota Transplant (FMT) After Treatment for a First Episode of Clostridium Difficile Infection (CDI)

Population: Patients >= 18 years hospitalized at Boston Medical Center (BMC) with a first documented episode of CDI. Intervention: 30 FMT capsules administered orally under direct observation within 7 days of completion of 10-14 day treatment of...
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US Clinical Trial NCT02569762 – NIH – Jul 21, 2015

Assessment of the Effect of Artificial Sweeteners on Gut Microbiota and Glucose Metabolism

The trial will be 12 weeks randomized, cross-over and double blinded with 2 treatment intervention ( sucralose and aspartame) , there will be a run in period (4 weeks), then phase 1 treatment period for two weeks followed by four weeks washout perio...
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US Clinical Trial NCT02572882 – NIH – Aug 19, 2015

A Multi-center Study to Characterize the Gut Microbiome of Individuals With End-stage Renal Disease Treated With Maintenance Hemodialysis, and to Explore Effects of P-inulin on the Gut Microbiome

This primary objective of this exploratory study is to characterize the safety and tolerability of p-inulin (Prebiotin®, provided by JGI Medical) in altering the composition and function of the human gut microbiome, thereby reducing the generation o...
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US Clinical Trial NCT03582826 – NIH – Jun 11, 2018

Dynamics of the Gut Microbiota in Idiopathic Malodor Production

Human odorprints, mostly owing to the microbiome, have proven their value as biomarkers of health and environmental exposures. In recent years, microbial networks responsible for localized malodors such as halitosis or axillary odor have been mapped...
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US Clinical Trial NCT03726645 – NIH – Mar 23, 2018

The Role of Gut Microbiota in the Pathogenesis of Ankylosing Spondylitis (AS), and the Effect of Fecal Microbiota Transplantation on Gut Microbiota, Gut Wall Inflammation and Clinical Activity of AS

This is a double-blind placebo- controlled randomized pilot study with 20 patients with active AS from 2 Finnish outpatient clinics. An ileocolonoscopy will be performed to all patients. 10 patients will receive FMT with feces of one of two healthy...
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US Clinical Trial NCT02256592 – NIH – Oct 1, 2014

Reconstitution of the Gut Microbiome to Reduce HIV-Associated Inflammation

Despite antiretroviral therapy (ART), chronic immune activation persists and is a major driver of HIV disease progression and mortality among HIV-infected individuals. Importantly, persistent inflammation is strongly associated with increased cardio...
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US Clinical Trial NCT03815786 – NIH – Nov 23, 2018

XUANRO4 - NATURE 3.1 - Nuovo Approccio Per la Riduzione Delle Tossine Uremiche Renali, REGIONE PUGLIA - FSC 2007-2013 Ricerca. Intervento "Cluster Tecnologici Regionali"

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US Clinical Trial NCT03863249 – NIH – Feb 25, 2019

Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection: Randomized Clinical Trial.

Periodontitis in a chronic disease caused by bacteria present in the subgingival flora, which induces an inflammatory response of periodontal tissues. It has been suggested that some periodontal pathogens may be inaccessible to mechanical periodonta...
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US Clinical Trial NCT03414775 – NIH – Jan 22, 2018

Influences of High-fiber, Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children

The gastrointestinal microbiome has been shown to be altered in critically-ill children such that there is a larger shift toward pathogenic bacteria. Previous studies have shown that probiotics, fecal transplants, antibiotic decontamination, and die...
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US Clinical Trial NCT02692495 – NIH – Feb 16, 2016

Evaluation of Gastrointestinal and Nutritional Diagnostic Tests as Potential Screening Tools for Metabolic Body Odor and Halitosis

Many yet uncharacterized medical conditions including inborn and acquired errors of metabolism or skewed microbiome could be responsible for unpredictable and uncontrollable episodes of body odor and halitosis. These conditions have dramatic impact...
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US Clinical Trial NCT03523936 – NIH – May 2, 2018

Gut Microbiota and Antibiotics - Prevention of Side Effects by New Prebiotics

Thirty children (2-6 years of age), who require antibiotic treatment assessed by a doctor, will be enrolled in the study. The children will be randomized to receive either the prebiotic product or placebo during the course of antibiotic treatment....
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US Clinical Trial NCT02526251 – NIH – Aug 4, 2015

Does the Microbiome in IBD Change Alongside Special Treatment Scenarios?

Among 2.500 IBD patients the investigators will consecutively from the Gastroenterology out-patient clinic at North Zealand University Hospital recruit in total 120 in the study. At the out-patient consultation IBD patients will be informed about t...
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US Clinical Trial NCT03616015 – NIH – Jul 19, 2018

Intestinal Dysbiosis and Immune Reconstitution After Allogeneic Hematopoietic Cell Transplantation

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the major curative therapeutic approach for hematologic neoplasms. After HSCT, patients have a compromised GI mucosal barrier and an altered microbiota, also called dysbiosis. The lat...
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US Clinical Trial NCT03900338 – NIH – Mar 29, 2019

Intestinal Microbiota and Its Relationship With Vascular Structure and Function and Cardiovascular Risk, Phase I (MIVAS Study)

Aim: analyse differences in intestinal microbiota between patients with and without arterial stiffness, measured by pulse wave velocity. Design and setting: An observational case-control study. Study population: The investigators will select 324 su...
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US Clinical Trial NCT03633188 – NIH – Jul 17, 2018

Stool Biobanking and Impact of Antimicrobials on the Gut Microbiota in Patients With Bone and Joint Infection

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US Clinical Trial NCT03330444 – NIH – Oct 24, 2017

Development of a Non-invasive Diagnosis Tool for the Analysis of the Microbiota to Improve Reproductive Outcomes in Infertile Patients.

Embryonic implantation is a critical process to the survival of the species, that is relatively inefficient especially in humans. Key elements are the embryo, the maternal endometrium, and the cross-communication between them using different scienti...
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US Clinical Trial NCT03151148 – NIH – May 10, 2017

A First in Man Evaluation of the Safety and Efficacy of an Allogeneic Targeted Microbiome Transplant in Adults With Moderate-to-Severe Atopic Dermatitis (ADRN-08)

This study will enroll adult participants, 18-60 years of age, with moderate-to-severe atopic dermatitis (AD) and a positive Staphylococcus aureus (S. aureus) colonized lesion (at least 15 cm^2 in size) on the upper extremities. Participants who ar...
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US Clinical Trial NCT03043300 – NIH – Feb 2, 2017

A Pilot Study to Assess the Intestinal MicroBiota Diversification States and Changes in U.S. Travelers After Return From Short-Term Travel to an Overseas South(East) Asian Destination

Travelers' diarrhea is the most common illness experienced by those going overseas. Estimates vary, but incidence has been reported to range between 30-60%, depending on travel destination and season. Multiple organisms have been implicated as cause...
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US Clinical Trial NCT01641341 – NIH – May 9, 2011

Irritable Bowel Syndrome Evaluation and Treatment in Primary Care

This study will take place in 8 practices which are members of the AAFP NRN. Eligible practices must be able to identify at least 25 active patients (seen in last 24 months) with a diagnosis of IBS from billing or electronic health record data to be...
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US Clinical Trial NCT03523403 – NIH – May 1, 2018

The Apple Study: Investigating the Effects of Whole Apple Consumption on Risk Factors for Chronic Metabolic Diseases in Overweight and Obese Adults

This study will be conducted at the Human Nutraceutical Research Unit (HNRU) at the University of Guelph. The research will be carried out in accordance with the SOPs established by the HNRU, which formalize the Department of Human Health and Nutrit...
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US Clinical Trial NCT03548051 – NIH – May 24, 2018

Phase 1/2 Placebo Controlled, Partially-Blinded Clinical Trial to Assess the Safety and Efficacy of Microbial Restoration by Enema With Banked and Thawed Processed Stool in Individuals With One or More Recurrences of Clostridium Difficile Associated Disease (CDAD)

This is a multi-center, randomized, placebo controlled, partially blinded trial comparing the safety and efficacy of fecal microbiota transplantation versus placebo both delivered by rectal enema in subjects 18 years of age or older with recurrent C...
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US Clinical Trial NCT03225950 – NIH – Jul 19, 2017

Interaction Between Immune Cells and Bacteria Associated With Periodontitis

Periodontitis is a prevalent, multifactorial inflammatory disease characterized by the interaction between microorganisms organized in biofilms on tooth surfaces and host immune cells, leading to an inflammatory destruction of the tooth-supporting t...
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