Searching for keyword:"Depression"

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US Clinical Trial NCT03427528 – NIH – Jan 29, 2018

Integrating Text Messages Into the Mothers and Babies Course to Address Depression in Low-Income Women and Their Partners

Enhancements to Mothers and Babies are warranted to address the mental health of both parents, via the home visitation service delivery model where many of the most at-risk families enter into provider-client relationships during their child's infan...
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US Clinical Trial NCT00221494 – NIH – Sep 13, 2005

Can Additional Drug Therapy Accelerate Response Time to Antidepressants: A Double-blind, Placebo-controlled Randomization Research Study for Major Depression

Major depression is an illness with substantial personal and economic morbidity (Greenberg et al.1993) and antidepressants are the cornerstone of treatment. As antidepressants usually require 3-6 weeks of use before a response occurs, an effective a...
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US Clinical Trial NCT00276900 – NIH – Jan 11, 2006

Prevention of Recurrent Postpartum Depression

Depression after pregnancy is called postpartum depression and may be caused by a rapid change in hormone levels during and immediately after pregnancy. Researchers believe that it is one of the most common complications linked to pregnancy. This ty...
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US Clinical Trial NCT03433651 – NIH – Feb 8, 2018

Creatine Monohydrate Use for Preventing Altitude Induced Depression

Subjects will be in this research study if they moved to Creech AFB from an elevation of less than 2.000 feet within the last month. The purpose of this study is to see if creatine monohydrate is effective in preventing altitude-induced depression....
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US Clinical Trial NCT00174876 – NIH – Sep 9, 2005

An Open-Label Study of Aripiprazole (Abilify) as an Augmentation Agent in Patients With Treatment-Resistant Depression

This is a prospective, open-label study that will examine the clinical utility and safety of adding the atypical antipsychotic aripiprazole as an augmenting agent to antidepressant therapy in treatment-resistant depressed patients. The author's a pr...
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US Clinical Trial NCT01453114 – NIH – Oct 12, 2011

Cognitive-Behavioral Therapy in Women Discontinuing Antidepressant for Pregnancy

The current study is a small year-long pilot to collect data for a planned larger, randomized control trial in the future. The current protocol focuses on modifying a Cognitive-Behavioral Therapy (CBT) recurrence prevention protocol for the study po...
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US Clinical Trial NCT00437385 – NIH – Feb 20, 2007

Phase 1 Study: Evaluation of Three Continuation Therapies After Acute Electroconvusive Therapy (ECT) Concerning Efficacy and Cognition in Severly Depressed Patients

BACKGROUND While electroconvulsive therapy (ECT) in major depression is effective, high relapse rates and cognitive effects limit its long-term use. Continuation treatment after ECT with combinations of C-ECT or psychotherapy and medication may decr...
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EU Clinical Trial 2016-001637-27 – EMA – Sep 20, 2016

A randomised pragmatic trial comparing the clinical and cost effectiveness of lithium and quetiapine augmentation in treatment resistant depression.

Main objective of the trial: The primary aim of this research study is to determine if it is more clinically effective to decide to prescribe lithium or quetiapine augmentation therapy for patients with treatment resistant depression followed up over...
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US Clinical Trial NCT00152529 – NIH – Sep 7, 2005

"C.A.T.C.H.-I.T." Competent Adulthood Transition With Cognitive, Humanistic and Interpersonal Teaching

Our study goal is to develop a prototype combination primary care-web based depression intervention for young adults ages 18-24years in urban community and university settings. The content development will include: (1) two brief (15 minutes) primary...
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US Clinical Trial NCT00122031 – NIH – Jul 15, 2005

Deep Brain Stimulation for Treatment-Refractory Major Depression

Despite advances in pharmacotherapy and psychotherapy for major depression, a substantial number of patients fail to improve significantly even after years of conventional and experimental interventions. Bilateral deep brain stimulation (DBS) to the...
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US Clinical Trial NCT00251043 – NIH – Nov 7, 2005

Antepartum Study on Use of Interpersonal Psychotherapy at 3 New York City Sites

The prevalence of antepartum depression (APD) increases twofold in women with poor social supports, low socioeconomic status (SES), and negative life events. APD may cause low birth weight, premature labor, and eclampsia. APD is also one of the best...
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US Clinical Trial NCT00228033 – NIH – Sep 26, 2005

Calcium for the Prevention of Postpartum Depression

Postpartum depression is a combination of physical, emotional, and behavioral changes that occur after childbirth. The rapid drop in estrogen and progesterone levels, as well as the social and psychological changes resulting from the birth of a chil...
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US Clinical Trial NCT02239094 – NIH – Sep 9, 2014

Identification of Biosignatures for Lurasidone (Latuda) Response in Bipolar Depression

The study proposes to enroll 20 participants with a bipolar disorder who are currently in an episode of major depression.Magnetic resonance imaging (MRI), recordings of brain electrical activity (EEG), and psychological testing to explore possible p...
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US Clinical Trial NCT00206141 – NIH – Sep 13, 2005

Multi-centre, Double-blind, Randomised, Parallel-group, Placebo-controlled, Phase 3 Study of the Efficacy & Safety of Quetiapine Fumarate & Lithium as Monotherapy in Adult Patients With Bipolar Depression for 8 Weeks & Quetiapine in Continuation (Abbreviated)

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US Clinical Trial NCT01309516 – NIH – Jan 22, 2011

Efficacy of Learning Through Play Plus Intervention to Reduce Maternal Depression for Women With Under-nourished Children: A Randomized Controlled Trial From Pakistan

A number of individual and group interventions targeting maternal depression have been developed and tested, mostly in developed countries. Group-based approaches have usually been used to improve outcomes in children through parent-training program...
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US Clinical Trial NCT03175887 – NIH – May 3, 2017

Dorsolateral Versus Medial Prefrontal TMS for Depression

While transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is an FDA approved treatment for depression, a growing and converging database suggests the medial prefrontal cortex (MPFC) may be even more critical to...
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US Clinical Trial NCT00178035 – NIH – Sep 13, 2005

Geriatric Depression: Neurobiology of Treatment

The clinical response to antidepressant treatment in the elderly is variable and often slow, and difficult to predict reliably before 4-5 weeks of treatment. The delayed onset of antidepressant activity is particularly problematic in the elderly, pr...
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US Clinical Trial NCT01399671 – NIH – Jul 12, 2011

Clinical Randomized Trial to Evaluate the Efficacy of Vestibular Stimulation as Coadjuvant Therapy in Major Depression

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US Clinical Trial NCT03949465 – NIH – May 6, 2019

An Open Label Trial of Repetitive Transcranial Magnetic Stimulation (rTMS) for Peri-partum Depression.

Peripartum Depression (PPD) is common and severely disabling. Pharmacological intervention remains the first line of treatment, however many patients do not experience any benefits from them. Furthermore, many women are hesitant about pharmaceutical...
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US Clinical Trial NCT00852202 – NIH – Feb 25, 2009

A Double-blind, Placebo-controlled Study of RGH-188 (Cariprazine) in Bipolar Depression

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US Clinical Trial NCT00926653 – NIH – Jun 22, 2009

Anterior Cingulate Activation in Geriatric Depression

Older adults with depression often also suffer from executive dysfunction—problems with planning, impulse control, and reasoning. Executive dysfunction in older adults predicts poor or delayed response to antidepressant treatment and has been associ...
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US Clinical Trial NCT01200069 – NIH – Aug 19, 2010

Intravenous Ibuprofen/Caldolor for Post-Electroconvulsive Therapy Myalgia

IV ibuprofen (trade name Caldolor) is a novel therapeutic modality approved by the US Food and Drug Administration (FDA) in June 2009 for the treatment of mild to moderate pain, as an adjunct to opioid analgesics, and for the reduction of fever. Ibu...
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US Clinical Trial NCT01860443 – NIH – May 18, 2013

Telepsychiatry-Based Collaborative Program to Improve the Management of Adolescent Depression in Primary Care Clinics in the Araucanía Region, Chile: A Randomized Controlled Trial

General aim To carry out a randomized controlled trial to compare the efficacy of telepsychiatry intervention versus usual care to treat depression in adolescents in primary care clinics in the Araucanía Region, Chile. Specific aims 1. To compare...
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US Clinical Trial NCT03102736 – NIH – Mar 31, 2017

Pharmacologic Attenuation of Ketamine Using Nitroprusside

Ketamine is an effective fast-acting therapeutic intervention for patients with treatment refractory depression that is known to have the unwanted effect of inducing temporary psychotomimetic symptoms (i.e., delusions, hallucinations and thought dis...
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US Clinical Trial NCT03119597 – NIH – Mar 23, 2017

A Randomized, Double-blind, Placebo-controlled Study Investigating the Effects of Blueberry Anthocyanin on Cognitive Functioning and Mood in Adolescents.

Interventions: Flavonoid drink and a matched placebo will be used in this study. Flavonoid drink will contain approximately, 13g of freeze dried wild blueberry powder, containing 250mg of anthocyanin flavonoid, mixed with 170ml water and flavored wi...
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US Clinical Trial NCT02919280 – NIH – Sep 23, 2016

Dallas 2K: A Natural History Study of Depression

This is a non-randomized, natural history, non-treatment, longitudinal cohort study. Participants will be receiving standard of care treatment for depression and other comorbidities from their treating clinician and will be allowed to continue such...
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US Clinical Trial NCT02272387 – NIH – Oct 16, 2014

Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression?

Our study recruitment will be at a single center in our pregnant private and clinic population. We will recruit eligible pregnant women 20 weeks 0 days or less. On study entry, patients will complete a demographic survey, vitamin D exposure survey,...
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US Clinical Trial NCT03870776 – NIH – Feb 26, 2019

Double-blind, Controlled, Randomized Phase 2 Study of Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of a Daily Oral Administration of MAP4343 During 6 Weeks in Antidepressant-non Responders Patients Experiencing a Major Depressive Episode

This will be a phase II, versus placebo, multicentre, double blind, randomized, parallel study in male or female patients with drug resistant depression. This study targets the antidepressant non-responders' patients who have already experienced at...
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US Clinical Trial NCT00277108 – NIH – Jan 12, 2006

Open Label Variable Dose Escitalopram (Lexapro) in the Treatment of Patients With Postpartum Major Depression: A Pilot Study

Primary objectives: Remission of Major Depression: To determine the efficacy of a flexibly titrated dose of Escitalopram (10mg to 20 mg) in the treatment of women with postpartum depression. The primary outcome measure will be remission of major dep...
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US Clinical Trial NCT00178880 – NIH – Sep 12, 2005

MRI Imaging of Chronobiologic Abnormalities in Depression

The purpose of the study is to identify and understand patterns of brain activity when people are depressed. The study will use an imaging method called Magnetic Resonance Imaging (MRI) which does not involve any exposure to radioactivity or radioac...
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US Clinical Trial NCT00226642 – NIH – Sep 23, 2005

Behandlung Von Leichten Und Unterschwelligen Depressionen. Eine Randomisierte, Kontrollierte Studie Zum Wirksamkeitsnachweis Eines Serotonin-Wiederaufnahme-Hemmers (SSRI), Einer Kognitiven Verhaltenstherapie Und Einer Freien Therapiewahl ("Treatment of Mild and Subthreshold Depressive Disorders". A Randomized, Controlled Trial on the Efficacy of a Serotonin-Reuptake-Inhibitor (SSRI), a Cognitive-Behavioral Therapy and of Free Choice Between SSRI and CBT")

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US Clinical Trial NCT00491686 – NIH – Jun 25, 2007

A Phase IIa, Multi-Center, Randomized, Double-blind, Placebo-controlled, Parallel-Group Study to Assess the Antidepressant Effect and Onset of Effect of AZD6765 in Treatment-Resistant Major Depressive Disorder Patients

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US Clinical Trial NCT01049347 – NIH – Jan 12, 2010

Hypothalamus-pituitary-adrenal System: Role of the Mineralocorticoid Receptor and Longitudinal Study in Depressed Patients

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US Clinical Trial NCT01128452 – NIH – May 19, 2010

A 4-Week, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Investigate the Safety and Efficacy of EVT 101 as Monotherapy in Patients With Treatment-Resistant Major Depression

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US Clinical Trial NCT01341925 – NIH – Apr 22, 2011

Omega-3 Fatty Acids & Psychoeducational Psychotherapy for Childhood Depression

Approximately 2 to 4% of children experience either major depressive disorder or dysthymic disorder and 5 to 10% of children and adolescents experience subsyndromal depressive symptoms (Birmaher et al). Due to its prevalence and association with sig...
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US Clinical Trial NCT01545843 – NIH – Jan 12, 2012

Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression

Depression is common and associated with social and economic costs. Although antidepressant medications are an effective treatment for depression, it can take as long as 6-8 weeks before symptoms improve, and 20-35% of individuals who use antidepres...
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US Clinical Trial NCT01200901 – NIH – Sep 7, 2010

Quetiapine in Melancholic Depression: an fMRI Study of Treatment-induced Changes in the Neurocircuitry of the Stress Response

Patients with major depression (N=20) will be recruited for the 8-week clinical trial of quetiapine XR 100 - 300 mg (flexible dosing). Patients who consent to participate will be referred for an initial fMRI scanning session prior to the initiation...
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US Clinical Trial NCT01208428 – NIH – Sep 22, 2010

Cognitive Behavioral Treatments for Depression in Patients With Chronic Illness

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US Clinical Trial NCT01392963 – NIH – Jul 8, 2011

The Treatment of Depression With Botulinum Type A Toxin (Botox): A Randomized, Double Blind, Crossover Study

Participants will be assigned to receive either placebo or botulinum toxin injections in the forehead
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US Clinical Trial NCT03000530 – NIH – Dec 14, 2016

A Phase 2, Two-Part (Open-Label Followed by Double-Blind) Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of SAGE-217 in the Treatment of Adult Subjects With Moderate to Severe Major Depressive Disorder

Part A of the study is an open-label design with dosing of SAGE-217 for 14 days. Part B of the study is a randomized, double-blind, parallel-group, placebo-controlled design. Eligible subjects will be randomized to SAGE-217 or placebo for 14 days.
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US Clinical Trial NCT03420755 – NIH – Jan 29, 2018

Integrating Text Messages Into the Mothers and Babies Course to Address Depression in Low-Income Women and Their Partners

Despite the well-established negative effects of postpartum depression on mother and child, most efforts have been directed at treating women already exhibiting depressive episodes rather than prevention. Emphasis on treatment neglects the large num...
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EU Clinical Trial 2010-024364-18 – EMA – Apr 12, 2011

The effects of ARA290 on the cognitive and neural processing of emotions in healthy volunteers

Main objective of the trial: In healthy individuals, study the effects of a single dose of ARA290 on the cognitive and neural processing of emotions.
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US Clinical Trial NCT00043602 – NIH – Aug 9, 2002

Clinician Managed Interpersonal Psychotherapy

CM-IPT is delivered in 12 sessions over the course of a year. Standard IPT is delivered in 12 sessions in the first 12 weeks after treatment assignment.
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US Clinical Trial NCT00177996 – NIH – Sep 13, 2005

Pharmacotherapy in Depression With Panic Spectrum

Researchers at the University of Pittsburgh Medical Center Health System are currently recruiting men and women, ages 18 to 60, to examine the effectiveness of the FDA-approved medication sertraline (Zoloft) for major depression. Participants will...
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US Clinical Trial NCT00178906 – NIH – Sep 12, 2005

Acoustical Properties of Speech as Indicators of Suicidal Risk

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US Clinical Trial NCT02663180 – NIH – Jan 19, 2016

Effects of an Educational Program on Depression Literacy and Stigma Among Students of Secondary Schools in Jazan City

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US Clinical Trial NCT02443194 – NIH – May 3, 2015

The Effect of Duloxetine on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients

This study was designed to prospectively randomized, controlled, double-blind study.This method of recruitment patients who undergo resection or biopsy of glioblastoma (newly diagnosed glioblastoma), immediately after diagnosis, patients will receiv...
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US Clinical Trial NCT02378415 – NIH – Aug 15, 2012

Subanesthetic IV Bolus Ketamine in the Treatment of Acute Depression

A determination for hospital admittance by a consulting psychiatrist will be made prior to study participation. Only those persons being admitted to the psychiatric ward will be eligible to enroll in this study. After consenting to participate in th...
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US Clinical Trial NCT02285504 – NIH – Oct 22, 2014

An Open-Label Proof-of-Concept Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of SAGE-547 Injection in the Treatment of Adult Female Patients With Severe Postpartum Depression

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US Clinical Trial NCT00711568 – NIH – Jul 3, 2008

A Clinical Trial of Magnetic Stimulation in Depression

Despite the utility of modern psychotropic medications, depression remains a medical problem with major societal impact. Electroconvulsive therapy (ECT) is an effective somatic treatment for depression. However, ECT has disadvantages, including risk...
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