Searching for keyword:"Atrial fibrillation"

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US Clinical Trial NCT00111488 – NIH – May 20, 2005

Randomized Study of Surgical Ablation With Microwave Energy for the Treatment of Atrial Fibrillation

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US Clinical Trial NCT00429884 – NIH – Jan 31, 2007

Studies of Disorders and Mechanisms Related to Atrial Fibrillation Before and After DC-Conversion: Polysomnography, Heart Rate Variability and 24h Holter.

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US Clinical Trial NCT03917992 – NIH – Apr 14, 2019

The Baseline Features and CHA2DS2 VASc /HAS BLED Scores of Jordanian Patients With Atrial Fibrillation and the One Year Outcome

The investigators are introducing The Jordan Atrial Fibrillation Study: Baseline Risk Scores and One Year Outcome" which is an investigator initiated, prospective, non interventional, observational study. Medical research and clinical studies in Jo...
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US Clinical Trial NCT01686542 – NIH – Sep 13, 2012

Circumferential Pulmonary Vein Isolation (CPVI) Plus Renal Sympathetic Modification Versus CPVI Alone for AF Ablation: a Pilot Study

Basic studies suggested that sympathetic nerves over-activity played an important role in the pathophysiological changes of arrhythmia occurrence. Present studies of renal ablation show a new method to decrease sympathetic nerves activity. Circumfer...
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US Clinical Trial NCT00744835 – NIH – Aug 28, 2008

Atrial Fibrillation Ablation Pilot Study- Study Number AFI-20

The study shall be conducted according to ISO 14155. Results of this research study will be used to assess the performance and safety of the System and its components. Data may be combined with similar research at additional sites to create a greate...
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US Clinical Trial NCT00265629 – NIH – Dec 14, 2005

A Clinical Investigation of Radiofrequency Ablation for the Treatment of Atrial Fibrillation Using the High Density Mesh Bard Ablation System

This study is intended to evaluate the safety and preliminary effectiveness of the RFMesh BAS for electrophysiological mapping and radiofrequency ablation in the region of the ostium of a targeted pulmonary vein in the treatment of drug refractory p...
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US Clinical Trial NCT00863382 – NIH – Mar 16, 2009

Comparison of External Event Recorders With Implantable Monitor for Post Atrial Fibrillation Monitoring: Assessment of Cost and Efficacy

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US Clinical Trial NCT00215774 – NIH – Sep 14, 2005

Targeted Pharmacological Reversal of Electrical Remodeling After Cardioversion.

Details of the trial are described in a design paper published in the American Heart Journal (1). Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with approximately one million affected patients in Germany. Current estimate...
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US Clinical Trial NCT01483183 – NIH – Nov 29, 2011

A Multi-center, Parallel-group, Double-blind, Placebo-controlled, Randomized, Ascending Dose Trial to Determine the Safety, Tolerability, Pharmacokinetics and Efficacy of Intravenous Infusions of OPC-108459 Administered to Subjects With Paroxysmal and Persistent Atrial Fibrillation

This trial will test the pharmacokinetic and pharmacodynamic characteristics of ascending doses of OPC-108459 in separate populations of paroxysmal and persistent AF subjects. The trial will consist of two parts. Each part will evaluate two populat...
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US Clinical Trial NCT00431782 – NIH – Feb 2, 2007

An Open-Label Multi-Center Study of ATI-5923 for Anticoagulation in Patients With Atrial Fibrillation

ATI-5923 is a structural analog of warfarin that is being developed as an oral anticoagulant. It has a similar pharmacological profile to warfarin but was designed to provide more uniform and stable anticoagulation. ATI-5923 is a selective, non-comp...
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US Clinical Trial NCT00231296 – NIH – Sep 30, 2005

A Clinical Study to Evaluate the Safety and Efficacy of the CryoCor(TM)Cardiac Cryoablation System for the Treatment of Paroxysmal Atrial Fibrillation

The purpose of this prospective, randomized multi-center clinical study is to establish the benefits of the CryoCor(TM) Cardiac Cryoablation System for treating symptomatic paroxysmal atrial fibrillation (PAF) in comparison to treatment with anti-ar...
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US Clinical Trial NCT00248274 – NIH – Nov 2, 2005

Assessment of Atrial Tissue Obtained From Patients Undergoing Heart Surgery

Atrial fibrillation (AF), a disorder of heart rhythm, is epidemic in the United States, affecting nearly 3 million people. AF arises in a variety of settings, often in association with other cardiac disease. Demographic and clinical factors can be u...
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US Clinical Trial NCT01370629 – NIH – Jun 8, 2011

A Prospective Observational Registry Study to Characterise Normal Conditions of Use, Dosing and Safety Following Administration of Vernakalant IV Sterile Concentrate

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US Clinical Trial NCT01673139 – NIH – Aug 22, 2012

Effect of 3 Years of Exercise in Patients With Atrial Fibrillation - A Generation 100 Substudy

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US Clinical Trial NCT00798356 – NIH – Nov 25, 2008

The Effect of Yoga on Arrhythmia Burden and Quality of Life in Patients With Paroxysmal Atrial Fibrillation

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US Clinical Trial NCT01687036 – NIH – Jul 18, 2012

Cryoablation of Atrial Fibrillation Using a Novel Cryoablation System

Therefore, the primary endpoint will be a measurement of the following parameters and expressed in number of participants with AE: - deformation of the catheter loop resulting in entrapment of the catheter in the heart and difficulties removing the...
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US Clinical Trial NCT00313157 – NIH – Apr 10, 2006

Rate Control in Atrial Fibrillation

This is a randomised, single blinded, cross-over study comparing the efficacy of metoprolol 100 mg o.d., verapamil 240 mg o.d., diltiazem 360 mg o.d. and carvedilol 25 mg o.d. in reducing ventricular rate in atrial fibrillation. A total of 60 patien...
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US Clinical Trial NCT00689598 – NIH – Mar 30, 2008

Use of Spironolactone to Treat Patients With Paroxysmal Atrial Fibrillation- A Multi-Center, Prospective, Randomized, Placebo-Controlled, Double Blind Study

To determine whether or not adding spironolactone can prevent or delay the occurrence of paroxysmal atrial fibrillation in patients who have received propafenone treatment.
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EU Clinical Trial 2018-002979-17 – EMA – Dec 17, 2018

Use of doxapram as a new antiarrhythmic drug for a specific therapy of atrial fibrillation

Main objective of the trial: Antiarrhythmic potential for cardioversion from AF to SR after i.v. administration of doxapram
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US Clinical Trial NCT01206452 – NIH – Sep 20, 2010

Use of Oral Steroids Before Circumferential Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation to Improve Outcomes

The purpose of this study is: 1. To assess the efficacy of oral prednisone in improving the outcomes of pulmonary vein isolation with radiofrequency ablation. 2. To measure the inflammatory cytokine (TNF-α, IL-1, IL-6, IL-8) response to radiofrequ...
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US Clinical Trial NCT01198275 – NIH – Sep 9, 2010

N-3 Polyunsaturated Fatty Acids (n-3 PUFAs) in the Prevention of Atrial Fibrillation Recurrences After Electrical Cardioversion. A Prospective Randomized Study.

Atrial fibrillation (AF) is the most common sustained arrhythmia and represents an increasing burden on the healthcare system. Treatment of AF remains controversial. In patients on antiarrhythmic therapy, the one-year relapse rates of AF after cardi...
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US Clinical Trial NCT01660100 – NIH – Aug 1, 2012

Freedom From Atrial Arrhythmia in Atrial Fibrillation Patients After Permanent Pulmonary Vein Antrum Isolation With or Without Proven Left Atrial Posterior Wall Isolation

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US Clinical Trial NCT03082963 – NIH – Feb 27, 2017

Mapping Electrogram Morphology Recurrence for Atrial Fibrillation Ablation

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US Clinical Trial NCT01407588 – NIH – Jun 8, 2011

Manual Compared to Magnetic Navigation in Ablation for Atrial Fibrillation

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US Clinical Trial NCT00871390 – NIH – Mar 27, 2009

Complex Electrograms in Atrial Fibrillation: Spatiotemporal Organization and Mechanistic Insights and Organization in Acute Atrial Fibrillation Post Open Heart Surgery

Experiments in animal hearts demonstrated that some cases of atrial fibrillation (AF) may be maintained by a small number of drivers in the form of self-sustained, reentrant, electrical impulses located in the posterior left atrium (LA) wall, near t...
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US Clinical Trial NCT03827915 – NIH – Jan 28, 2019

Double Sequence External Defibrillation: A Randomized Controlled Trial in Patients With Atrial Fibrillation Refractory to DC Cardioversion

Patients presenting to the CCU with persistent AF for direct current (DC) cardioversion, who meet the inclusion criteria and fail to revert to normal sinus rhythm after two DC cardioversion attempts will be invited for enrollment in the study. No sa...
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US Clinical Trial NCT02351999 – NIH – Jan 13, 2015

Clinical Study of the TSP Crosser System For Transseptal Access and Left Atrial Catheter Navigation in Patients Undergoing Atrial Fibrillation Ablation

Transseptal (TS) catheterization is a critical step for left atrial (LA) interventions (atrial fibrillation ablation, LA appendage closure, mitral valve interventions). The availability of suitable tools and techniques is essential to safely perform...
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US Clinical Trial NCT01891825 – NIH – Jun 29, 2013

Persistent Atrial Fibrillation Ablation Trial

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US Clinical Trial NCT00542659 – NIH – Oct 10, 2007

Plasma ANP and NT-pro-BNP, Atrial Anatomical Change May Determine the Outcome of Maze Operation

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US Clinical Trial NCT00514735 – NIH – Aug 8, 2007

Tailored Treatment of Permanent Atrial Fibrillation - TTOP-AF

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US Clinical Trial NCT00523978 – NIH – Aug 31, 2007

A Randomized, Controlled Clinical Trial of Catheter Cryoablation in the Treatment of Paroxysmal Atrial Fibrillation.

STOP AF (PS-023) is a randomized, controlled study of subjects 18 to 75 years old who had been referred for ablative intervention after failing one or two (but not all three) anti-arrhythmic drugs used in the treatment of AF (flecainide, propafenone...
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US Clinical Trial NCT00196209 – NIH – Sep 12, 2005

Randomized Study Comparing Cardioversion vs. Catheter Ablation in Patients With Persistent Atrial Fibrillation

This randomized study compares two treatment strategies in patients with persistent atrial fibrillation: Cardioversion vs. catheter ablation. Cardioversion is a low risk standard treatment option for patients with persistent atrial fibrillation. How...
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US Clinical Trial NCT00833313 – NIH – Jan 5, 2009

Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older o...
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US Clinical Trial NCT01367197 – NIH – Jun 1, 2011

Randomised Study of the Effect of Exercise Training on Patients in Atrial Fibrillation

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US Clinical Trial NCT00712465 – NIH – Jul 8, 2008

A Phase I, Randomised, Open, Single-centre, Three-period Crossover Study to Evaluate the Effect of AZD1305 on the Pharmacokinetics of Digoxin After Repeated Oral Administration of AZD1305 and Digoxin to Young Healthy Male Volunteers

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US Clinical Trial NCT01057394 – NIH – Jan 26, 2010

Post-Market Randomized Controlled Trial: Endoscopically- Guided Ablation vs. Radiofrequency Ablation GuideD by Electroanatomical Mapping to Achieve Permanent Pulmonary Vein Isolation (En-GARDE)

The goal of the study was to compare two interventions, visually-guided endoscopic ablation to standard-of-care radiofrequency (RF) ablation. The study was terminated early by the Sponsor for business reasons before any participants were randomized...
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US Clinical Trial NCT01435161 – NIH – Sep 14, 2011

The Effect of Nifedipine Versus Telmisartan on Prevention of Atrial Fibrillation Recurrence in Hypertensive Patients With Paroxysmal Atrial Fibrillation by Intensive Lower Blood Pressure

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US Clinical Trial NCT00968279 – NIH – Aug 27, 2009

Coronary CT Angiography Using 320-Row Volume CT in Patients With Atrial Fibrillation

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US Clinical Trial NCT01645917 – NIH – Jul 18, 2012

SUstained PV Isolation With aRctic Front Advance

Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. It is estimated that more than 7 million people worldwide have the disease. Over the past decade, catheter ablation has become an accepted treatment for patient...
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US Clinical Trial NCT01991119 – NIH – Nov 7, 2013

Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation After DC Cardioversion

Atrial fibrillation is the most common arrhythmia requiring continuous therapy. Conversion to and maintenance of sinus rhythm is important. Propafenone and dronedarone has been used as treatment for maintenance of sinus rhythm after DC cardioversion...
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US Clinical Trial NCT02002923 – NIH – Dec 2, 2013

Pulmonary Vein Isolation Versus Botulinum Toxin Injection Plus Pulmonary Vein Isolation in Patients With Atrial Fibrillation

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US Clinical Trial NCT01710852 – NIH – Oct 9, 2012

A Phase 2 Study to Assess the Antiarrhythmic and Symptomatic Effect of the Second Generation Antisense Oligonucleotide ISIS 329993 Targeting CRP in Patients With Paroxysmal Atrial Fibrillation

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US Clinical Trial NCT02222090 – NIH – Aug 4, 2014

Therapy With New Oral Anticoagulants in Patients With Atrial Fibrillation and Renal Impairment

Current guidelines for the management of patients with atrial fibrillation (AF) recommend the use of novel oral anticoagulants (NOACs) in patients with non-valvular AF .Renal dysfunction has been shown to be an independent predictor of stroke or sys...
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US Clinical Trial NCT03242941 – NIH – Aug 4, 2017

AF Septal Pacing (Clinical Investigation Plan)

The evidence of treating AF by pacing is limited, although these algorithms are of interest, since they appear to be safe and usually add little additional cost. Using a computer model, a new dual-stage septal pacing has been developed.The proposed...
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US Clinical Trial NCT03546439 – NIH – May 21, 2018

VAscular Closure for Cardiac Ablation Registry (VACCAR)

Vascular Closure Devices (VCD) have been used to achieve hemostasis of arterial access sites following cardiac catheterization procedures. There is extensive literature available supporting the use of these devices for arterial access site closure,...
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US Clinical Trial NCT02802488 – NIH – Jun 13, 2016

Age Related D-dimer Evaluation for the Exclusion of a Left Atrium Thrombus in Patients With Atrial Fibrillation (ADDIT-AF)

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US Clinical Trial NCT00115843 – NIH – Jun 26, 2005

Atrial Fibrillation Rate Control Therapy Guided By Continuous Ambulatory Monitoring

This is an open, randomized controlled trial to compare a standard rate-control strategy with one using the Cardionet device to guide therapy for the management of atrial fibrillation. Patients presenting to an outpatient clinic or to the Emergency...
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US Clinical Trial NCT00343499 – NIH – Jun 21, 2006

A Single Center, Randomized Trial to Evaluate the Effects of Diovan to Maintain Sinus Rhythm in Patients With Persistent Atrial Fibrillation

To evaluate the efficacy of valsartan, added to standard AF therapy, to maintain sinus rhythm and extend the interval to first AF recurrence after cardioversion.Evaluate the efficacy of valsartan, begun prior to cardioversion, on the difficulty (num...
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US Clinical Trial NCT00791089 – NIH – Nov 13, 2008

Effect of Omega-3 Fatty Acids on Short and Long-Term Maintenance of Sinus Rhythm After Radiofrequency Catheter Ablation for Atrial Fibrillation

AF is the most prevalent arrhythmia, affecting >2 million Americans. Antiarrhythmic drug therapy often is ineffective to eliminate recurrent episodes of AF. In recent years radiofrequency catheter ablation has emerged as a highly effective treatm...
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US Clinical Trial NCT00584415 – NIH – Dec 20, 2007

Navi-Star Thermo-Cool Catheter For Ablation of Atrial Fibrillation

The ability of a saline irrigated catheter to deliver RF energy at higher power with a lower electrode-tissue interface temperature, combined with the anatomical guidance of electroanatomical mapping should allow: 1. Isolation of the pulmonary vein...
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